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While hundreds of artificial intelligence (AI) algorithms are now approved or cleared by the US Food and Drugs Administration (FDA), many studies have shown inconsistent generalization or latent bias, particularly for underrepresented…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Luke W. Sagers , James A. Diao , Luke Melas-Kyriazi , Matthew Groh , Pranav Rajpurkar , Adewole S. Adamson , Veronica Rotemberg , Roxana Daneshjou , Arjun K. Manrai

Paucity of medical data severely limits the generalizability of diagnostic ML models, as the full spectrum of disease variability can not be represented by a small clinical dataset. To address this, diffusion models (DMs) have been…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Janet Wang , Yunbei Zhang , Zhengming Ding , Jihun Hamm

Generative Artificial Intelligence (GenAI), particularly Large Language Models (LLMs), offer powerful capabilities for interpreting the complex data landscape in healthcare. In this paper, we present a comprehensive overview of the…

Machine Learning · Computer Science 2025-09-05 Ankit Shetgaonkar , Dipen Pradhan , Lakshit Arora , Sanjay Surendranath Girija , Shashank Kapoor , Aman Raj

Synthetic Electronic Health Records (EHRs) offer a valuable opportunity to create privacy preserving and harmonized structured data, supporting numerous applications in healthcare. Key benefits of synthetic data include precise control over…

Computation and Language · Computer Science 2025-04-28 Yihan Lin , Zhirong Bella Yu , Simon Lee

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu

In the era of big data, access to abundant data is crucial for driving research forward. However, such data is often inaccessible due to privacy concerns or high costs, particularly in healthcare domain. Generating synthetic (tabular) data…

Machine Learning · Computer Science 2026-04-10 Yaobin Ling , Xiaoqian Jiang , Yejin Kim

This study introduces a transformative framework for medical education by integrating semi-structured data with Large Language Models (LLMs), primarily OpenAIs ChatGPT3.5, to automate the creation of medical simulation scenarios.…

Computation and Language · Computer Science 2024-05-07 Scott Sumpter

This paper presents a comprehensive systematic review of generative models (GANs, VAEs, DMs, and LLMs) used to synthesize various medical data types, including imaging (dermoscopic, mammographic, ultrasound, CT, MRI, and X-ray), text,…

Deep learning methods have impacted almost every research field, demonstrating notable successes in medical imaging tasks such as denoising and super-resolution. However, the prerequisite for deep learning is data at scale, but data sharing…

Medical Physics · Physics 2024-02-16 Yongyi Shi , Wenjun Xia , Chuang Niu , Christopher Wiedeman , Ge Wang

Access to large-scale high-quality healthcare databases is key to accelerate medical research and make insightful discoveries about diseases. However, access to such data is often limited by patient privacy concerns, data sharing…

The medical field is one of the important fields in the application of artificial intelligence technology. With the explosive growth and diversification of medical data, as well as the continuous improvement of medical needs and challenges,…

Artificial Intelligence · Computer Science 2024-03-27 Jingyu Xu , Binbin Wu , Jiaxin Huang , Yulu Gong , Yifan Zhang , Bo Liu

The recent surge in research focused on generating synthetic data from large language models (LLMs), especially for scenarios with limited data availability, marks a notable shift in Generative Artificial Intelligence (AI). Their ability to…

Machine Learning · Computer Science 2024-03-08 Xu Guo , Yiqiang Chen

Generative AI is transforming image synthesis, enabling the creation of high-quality, diverse, and photorealistic visuals across industries like design, media, healthcare, and autonomous systems. Advances in techniques such as…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Fouad Bousetouane

Machine learning (ML) and Natural Language Processing (NLP) have achieved remarkable success in many fields and have brought new opportunities and high expectation in the analyses of medical data. The most common type of medical data is the…

Computation and Language · Computer Science 2018-12-10 Jiaqi Guan , Runzhe Li , Sheng Yu , Xuegong Zhang

Since the COVID-19 pandemic, clinicians have seen a large and sustained influx in patient portal messages, significantly contributing to clinician burnout. To the best of our knowledge, there are no large-scale public patient portal…

Artificial Intelligence · Computer Science 2024-11-12 Joseph Gatto , Parker Seegmiller , Timothy E. Burdick , Sarah Masud Preum

Synthetic data generation is an important application of machine learning in the field of medical imaging. While existing approaches have successfully applied fine-tuned diffusion models for synthesizing medical images, we explore potential…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Lakshmi Nair

Within the evolving landscape of deep learning, the dilemma of data quantity and quality has been a long-standing problem. The recent advent of Large Language Models (LLMs) offers a data-centric solution to alleviate the limitations of…

Computation and Language · Computer Science 2024-06-24 Lin Long , Rui Wang , Ruixuan Xiao , Junbo Zhao , Xiao Ding , Gang Chen , Haobo Wang

Deep learning algorithms require extensive data to achieve robust performance. However, data availability is often restricted in the medical domain due to patient privacy concerns. Synthetic data presents a possible solution to these…

Health informatics research is characterized by diverse data modalities, rapid knowledge expansion, and the need to integrate insights across biomedical science, data analytics, and clinical practice. These characteristics make it…

Artificial Intelligence · Computer Science 2025-09-24 Yuxiao Cheng , Jinli Suo

Medical image segmentation models struggle with rare abnormalities due to scarce annotated pathological data. We propose DiffAug a novel framework that combines textguided diffusion-based generation with automatic segmentation validation to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Maham Nazir , Muhammad Aqeel , Francesco Setti
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