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Analyses of targeted genomic sequencing data from next-generation-sequencing (NGS) technologies typically involves mapping reads to a reference sequence or clustering reads. For a number of species a reference genome is not available so the…

Genomics · Quantitative Biology 2016-02-16 Raunaq Malhotra , Daniel Elleder , Le Bao , David R Hunter , Raj Acharya , Mary Poss

Despite advances in machine learning (ML) and large language models (LLMs), rule-based natural language processing (NLP) systems remain active in clinical settings due to their interpretability and operational efficiency. However, their…

Computation and Language · Computer Science 2025-06-23 Jianlin Shi , Brian T. Bucher

We present a scalable, AI-powered system that identifies and extracts evidence-based behavioral nudges from unstructured biomedical literature. Nudges are subtle, non-coercive interventions that influence behavior without limiting choice,…

Initial fault detection and diagnostics are imperative measures to improve the efficiency, safety, and stability of vehicle operation. In recent years, numerous studies have investigated data-driven approaches to improve the vehicle…

Systems and Control · Electrical Eng. & Systems 2021-12-01 Ali Khodadadi , Soroush Ghandiparsi , Chen-Nee Chuah

Timely and accurate analysis of population-level data is crucial for effective decision-making during public health emergencies such as the COVID-19 pandemic. However, the massive input of semi-structured data, including structured…

Artificial Intelligence · Computer Science 2025-10-08 Daqian Shi , Xiaolei Diao , Jinge Wu , Honghan Wu , Xiongfeng Tang , Felix Naughton , Paulina Bondaronek

Referral workflow inefficiencies, including misaligned referrals and delays, contribute to suboptimal patient outcomes and higher healthcare costs. In this study, we investigated the possibility of predicting procedural needs based on…

Extracting structured medical insights from unstructured clinical text using Natural Language Processing (NLP) remains an open challenge in healthcare, particularly in non-English contexts where resources are scarce. This study presents a…

Artificial Intelligence · Computer Science 2025-11-21 Paulina Tworek , Miłosz Bargieł , Yousef Khan , Tomasz Pełech-Pilichowski , Marek Mikołajczyk , Roman Lewandowski , Jose Sousa

Background: Recruitment for cohorts involving complex liver diseases, such as hepatocellular carcinoma and liver cirrhosis, often requires interpreting semantically complex criteria. Traditional manual screening methods are time-consuming…

Artificial Intelligence · Computer Science 2025-02-27 Xiongbin Gui , Hanlin Lv , Xiao Wang , Longting Lv , Yi Xiao , Lei Wang

More than 200 generic drugs approved by the U.S. Food and Drug Administration for non-cancer indications have shown promise for treating cancer. Due to their long history of safe patient use, low cost, and widespread availability,…

Unsupervised methods are widely used to induce latent semantic structure from large text collections, yet their outputs often contain incoherent, redundant, or poorly grounded clusters that are difficult to validate without labeled data. We…

Computation and Language · Computer Science 2026-04-21 Tunazzina Islam

Cardiovascular diseases are becoming increasingly prevalent in modern society, with a profound impact on global health and well-being. These Cardiovascular disorders are complex and multifactorial, influenced by genetic predispositions,…

Computation and Language · Computer Science 2025-10-23 Kailai Yang , Yan Leng , Xin Zhang , Tianlin Zhang , Paul Thompson , Bernard Keavney , Maciej Tomaszewski , Sophia Ananiadou

Objective: The majority of detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time-consuming. Developing natural language processing (NLP)…

Automatic speech recognition (ASR) systems often degrade on accented speech because acoustic-phonetic and prosodic shifts induce a mismatch to training data, making labeled accent adaptation costly. However, common pseudo-label selection…

Computation and Language · Computer Science 2026-02-17 Ligong Lei , Wenwen Lu , Xudong Pang , Zaokere Kadeer , Aishan Wumaier

Rare diseases affect hundreds of millions worldwide, yet diagnosis often spans years. Convectional pipelines decouple noisy evidence extraction from downstream inferential diagnosis, and general/medical large language models (LLMs) face…

Matching cancer patients to clinical trials is essential for advancing treatment and patient care. However, the inconsistent format of medical free text documents and complex trial eligibility criteria make this process extremely…

Recent advances in large language models (LLMs) have yielded impressive performance on various tasks, yet they often depend on high-quality feedback that can be costly. Self-refinement methods attempt to leverage LLMs' internal evaluation…

Computation and Language · Computer Science 2025-12-01 Hikaru Asano , Tadashi Kozuno , Yukino Baba

Objective: Develop a cost-effective, large language model (LLM)-based pipeline for automatically extracting Review of Systems (ROS) entities from clinical notes. Materials and Methods: The pipeline extracts ROS section from the clinical…

Computation and Language · Computer Science 2026-05-15 Hieu Nghiem , Zhuqi Miao , Hemanth Reddy Singareddy , Jivan Lamichhane , Abdulaziz Ahmed , Johnson Thomas , Dursun Delen , William Paiva

Electronic health records include information on patients' status and medical history, which could cover the history of diseases and disorders that could be hereditary. One important use of family history information is in precision health,…

Computation and Language · Computer Science 2024-03-18 Xiang Dai , Sarvnaz Karimi , Nathan O'Callaghan

Reviewing radiology reports in emergency departments is an essential but laborious task. Timely follow-up of patients with abnormal cases in their radiology reports may dramatically affect the patient's outcome, especially if they have been…

Computation and Language · Computer Science 2018-12-06 Hamed Hassanzadeh , Mahnoosh Kholghi , Anthony Nguyen , Kevin Chu

While deep learning techniques have shown promising results in many natural language processing (NLP) tasks, it has not been widely applied to the clinical domain. The lack of large datasets and the pervasive use of domain-specific language…

Computation and Language · Computer Science 2019-06-20 Jiin Nam , Seunghyun Yoon , Kyomin Jung