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Classification models for electroencephalogram (EEG) data show a large decrease in performance when evaluated on unseen test sub jects. We reduce this performance decrease using new regularization techniques during model training. We…

Machine Learning · Computer Science 2023-10-16 Niklas Smedemark-Margulies , Ye Wang , Toshiaki Koike-Akino , Jing Liu , Kieran Parsons , Yunus Bicer , Deniz Erdogmus

Deep Neural Networks (DNNs) have begun to thrive in the field of automation systems, owing to the recent advancements in standardising various aspects such as architecture, optimization techniques, and regularization. In this paper, we take…

Machine Learning · Computer Science 2019-07-10 Anand Krishnamoorthy Subramanian , Nak Young Chong

Recent works have shown that on sufficiently over-parametrized neural nets, gradient descent with relatively large initialization optimizes a prediction function in the RKHS of the Neural Tangent Kernel (NTK). This analysis leads to global…

Machine Learning · Statistics 2020-04-28 Colin Wei , Jason D. Lee , Qiang Liu , Tengyu Ma

In The Cancer Genome Atlas (TCGA) data set, there are many interesting nonlinear dependencies between pairs of genes that reveal important relationships and subtypes of cancer. Such genomic data analysis requires a rapid, powerful and…

Applications · Statistics 2022-11-30 Siqi Xiang , Wan Zhang , Siyao Liu , Katherine A. Hoadley , Charles M. Perou , Kai Zhang , J. S. Marron

Deep neural networks (DNNs) are observed to be successful in pattern classification. However, high classification performances of DNNs are related to their large training sets. Unfortunately, in the literature, the datasets used to classify…

Machine Learning · Computer Science 2021-03-23 Zumray Dokur , Tamer Olmez

Machine learning (ML) has demonstrated significant promise in accelerating drug design. Active ML-guided optimization of therapeutic molecules typically relies on a surrogate model predicting the target property of interest. The model…

Purpose: This work aims at developing a generalizable MRI reconstruction model in the meta-learning framework. The standard benchmarks in meta-learning are challenged by learning on diverse task distributions. The proposed network learns…

Computer Vision and Pattern Recognition · Computer Science 2021-10-05 Wanyu Bian , Yunmei Chen , Xiaojing Ye , Qingchao Zhang

When performing named entity recognition (NER), entity length is variable and dependent on a specific domain or dataset. Pre-trained language models (PLMs) are used to solve NER tasks and tend to be biased toward dataset patterns such as…

Computation and Language · Computer Science 2022-01-12 Minbyul Jeong , Jaewoo Kang

Over-parameterized deep models usually over-fit to a given training distribution, which makes them sensitive to small changes and out-of-distribution samples at inference time, leading to low generalization performance. To this end, several…

Computer Vision and Pattern Recognition · Computer Science 2019-12-12 Saeid Asgari Taghanaki , Kumar Abhishek , Ghassan Hamarneh

Recurrent Neural Networks (RNNs) are powerful models for sequential data that have the potential to learn long-term dependencies. However, they are computationally expensive to train and difficult to parallelize. Recent work has shown that…

Machine Learning · Statistics 2015-10-07 César Laurent , Gabriel Pereyra , Philémon Brakel , Ying Zhang , Yoshua Bengio

Training Deep Neural Networks is complicated by the fact that the distribution of each layer's inputs changes during training, as the parameters of the previous layers change. This slows down the training by requiring lower learning rates…

Machine Learning · Computer Science 2015-03-03 Sergey Ioffe , Christian Szegedy

Due to the rapid development of high-throughput experimental techniques and fast-dropping prices, many transcriptomic datasets have been generated and accumulated in the public domain. Meta-analysis combining multiple transcriptomic studies…

Applications · Statistics 2019-05-17 Zhiguang Huo , Chi Song , George Tseng

To enable personalized cancer treatment, machine learning models have been developed to predict drug response as a function of tumor and drug features. However, most algorithm development efforts have relied on cross validation within a…

GNN-based methods have achieved excellent results as a mainstream task in drug response prediction tasks in recent years. Traditional GNN methods use only the atoms in a drug molecule as nodes to obtain the representation of the molecular…

Biomolecules · Quantitative Biology 2024-12-12 Kun Li , Jia Wu , Bo Du , Sergey V. Petoukhov , Huiting Xu , Zheman Xiao , Wenbin Hu

High-throughput sequencing is now regularly used for studies of the transcriptome (RNA-seq), particularly for comparisons among experimental conditions. For the time being, a limited number of biological replicates are typically considered…

Applications · Statistics 2013-06-18 Andrea Rau , Guillemette Marot , Florence Jaffrézic

Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed for natural language, which are unsuitable for DNA sequences…

Genomics · Quantitative Biology 2024-12-19 Lifeng Qiao , Peng Ye , Yuchen Ren , Weiqiang Bai , Chaoqi Liang , Xinzhu Ma , Nanqing Dong , Wanli Ouyang

Despite their impressive performance, Deep Neural Networks (DNNs) typically underperform Gradient Boosting Trees (GBTs) on many tabular-dataset learning tasks. We propose that applying a different regularization coefficient to each weight…

Machine Learning · Statistics 2018-10-25 Ira Shavitt , Eran Segal

Non-coding RNA (ncRNA) are RNA sequences which don't code for a gene but instead carry important biological functions. The task of ncRNA classification consists in classifying a given ncRNA sequence into its family. While it has been shown…

Genomics · Quantitative Biology 2019-05-17 Emanuele Rossi , Federico Monti , Michael Bronstein , Pietro Liò

Motivation. Cancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches to link organ- and tissue-level information from diagnostic images and…

Quantitative Methods · Quantitative Biology 2020-05-19 Nova F. Smedley , Suzie El-Saden , William Hsu

EEG recordings contain rich information about neural activity but are subject to artifacts, noise, and superficial differences due to sensors, amplifiers, and filtering. Independent component analysis and automatic labeling of independent…

Machine Learning · Computer Science 2025-12-05 Austin Meek , Carlos H. Mendoza-Cardenas , Austin J. Brockmeier