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Magnetic Resonance Imaging (MRI) is considered the gold standard of medical imaging because of the excellent soft-tissue contrast exhibited in the images reconstructed by the MRI pipeline, which in-turn enables the human radiologist to…

Brain decoding is a data analysis paradigm for neuroimaging experiments that is based on predicting the stimulus presented to the subject from the concurrent brain activity. In order to make inference at the group level, a straightforward…

Obtaining per-beat information is a key task in the analysis of cardiac electrocardiograms (ECG), as many downstream diagnosis tasks are dependent on ECG-based measurements. Those measurements, however, are costly to produce, especially in…

Batch normalization (BN) is a technique to normalize activations in intermediate layers of deep neural networks. Its tendency to improve accuracy and speed up training have established BN as a favorite technique in deep learning. Yet,…

Deep Learning (DL) methods have been used for electrocardiogram (ECG) processing in a wide variety of tasks, demonstrating good performance compared with traditional signal processing algorithms. These methods offer an efficient framework…

Breast cancer is the most common cancer in women worldwide. The most common screening technology is mammography. To reduce the cost and workload of radiologists, we propose a computer aided detection approach for classifying and localizing…

We perform differential expression analysis of high-throughput sequencing count data under a Bayesian nonparametric framework, removing sophisticated ad-hoc pre-processing steps commonly required in existing algorithms. We propose to use…

Decoding EEG signals is crucial for unraveling human brain and advancing brain-computer interfaces. Traditional machine learning algorithms have been hindered by the high noise levels and inherent inter-person variations in EEG signals.…

Artificial neural networks perform state-of-the-art in an ever-growing number of tasks, and nowadays they are used to solve an incredibly large variety of tasks. There are problems, like the presence of biases in the training data, which…

With the emergence of various molecular tasks and massive datasets, how to perform efficient training has become an urgent yet under-explored issue in the area. Data pruning (DP), as an oft-stated approach to saving training burdens,…

Inspired by the success of Convolutional Neural Networks (CNNs) for supervised prediction in images, we design the Deconvolutional Generative Model (DGM), a new probabilistic generative model whose inference calculations correspond to those…

Deep neural networks (DNN) have been used successfully in many scientific problems for their high prediction accuracy, but their application to genetic studies remains challenging due to their poor interpretability. In this paper, we…

Over-parameterized deep neural networks trained by simple first-order methods are known to be able to fit any labeling of data. Such over-fitting ability hinders generalization when mislabeled training examples are present. On the other…

Pan-cancer classification using transcriptomic (RNA-Seq) data can inform tumor subtyping and therapy selection, but is challenging due to extremely high dimensionality and limited sample sizes. In this study, we propose a novel deep…

Diagnosis of breast cancer has been well studied in the past. Multiple linear programming models have been devised to approximate the relationship between cell features and tumour malignancy. However, these models are less capable in…

Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histology offers more comprehensive information. However, existing…

Cancer and its subtypes constitute approximately 30% of all causes of death globally and display a wide range of heterogeneity in terms of clinical and molecular responses to therapy. Molecular subtyping has enabled the use of precision…

Deep Learning (DL) is considered the state-of-the-art in computer vision, speech recognition and natural language processing. Until recently, it was also widely accepted that DL is irrelevant for learning tasks on tabular data, especially…

Brain-Machine Interfacing (BMI) has greatly benefited from adopting machine learning methods for feature learning that require extensive data for training, which are often unavailable from a single dataset. Yet, it is difficult to combine…

Domain generalization is the task of learning models that generalize to unseen target domains. We propose a simple yet effective method for domain generalization, named cross-domain ensemble distillation (XDED), that learns domain-invariant…