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Multi-mode fiber (MMF) endoscopes are a new type of endoscope that use only a single optical fiber to transmit images, achieving much higher spatial resolution for a given diameter than commercial fiber bundle endoscopes. However, a…

Optics · Physics 2018-05-22 Ruo Yu Gu , Elaine Chou , Cory Rewcastle , Ofer Levi , Joseph M. Kahn

High-resolution fMRI provides a window into the brain's mesoscale organization. Yet, higher spatial resolution increases scan times, to compensate for the low signal and contrast-to-noise ratio. This work introduces a deep learning-based 3D…

Image and Video Processing · Electrical Eng. & Systems 2024-03-20 Hongwei Bran Li , Matthew S. Rosen , Shahin Nasr , Juan Eugenio Iglesias

This work presents a new super-resolution imaging approach by using subwavelength hole resonances. We employ a subwavelength structure in which an array of tiny holes are etched in a metallic slab with the neighboring distance $\ell$ that…

Optics · Physics 2020-10-07 Junshan Lin , Hai Zhang

Remote focusing of light in a graded-index medium via mode interference is demonstrated using exact analytical solutions of the wave equation. Strong focusing of light occurs at extremely long distances and it revivals periodically with…

Optics · Physics 2015-12-09 Nikolai I. Petrov

The flexible endoscope is a minimally invasive tool in clinical settings, but most of them rely on exogenous staining for diagnosis to provide qualitative information. Here, we demonstrated a flexible endoscopic microscopy (FEM) with…

We introduce a vortex phase transform with a lenslet-array to accompany shallow, dense, ``small-brain'' neural networks for high-speed and low-light imaging. Our single-shot ptychographic approach exploits the coherent diffraction, compact…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Baurzhan Muminov , Luat T. Vuong

Wideband spectrum sensing for low-altitude monitoring is critical yet challenging due to heterogeneous protocols,large bandwidths, and non-stationary SNR. Existing data-driven approaches treat spectrograms as natural images,suffering from…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Zhentao Yang , Yixiang Luomei , Zhuoyang Liu , Zhenyu Liu , Feng Xu

Spatiotemporal solitons (STSs) are localized solitary waves in both space and time that involve complex linear and nonlinear processes. Optical STSs have been observed in various media, but they are difficult to be realized in multimode…

Pattern Formation and Solitons · Physics 2016-07-20 Yao Wang , Shuo Yan , Jianqiu Xu , Yulong Tang

Lensless flexible fiber-bundle based endoscopes allow imaging at depths beyond the reach of conventional microscopes with a minimal footprint. These multicore fibers provide a simple solution for widefield fluorescent imaging when the…

Optics · Physics 2020-08-26 Noam Shekel , Ori Katz

Reconstructing the 3D location and size of microparticles from diffraction images - holograms - is a computationally expensive inverse problem that has traditionally been solved using physics-based reconstruction methods. More recently,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Ayush Paliwal , Oliver Schlenczek , Birte Thiede , Manuel Santos Pereira , Katja Stieger , Eberhard Bodenschatz , Gholamhossein Bagheri , Alexander Ecker

Stimulated emission depletion, or STED microscopy is a well-established super-resolution technique, but is ultimately limited by the chosen flourophore. Here we demonstrate STED microscopy with color centers in nanoscale flakes of hexagonal…

Mesoscale and Nanoscale Physics · Physics 2021-11-25 Prince Khatri , Ralph Nicholas Edward Malein , Andrew J. Ramsay , Isaac J. Luxmoore

Our work aims at using quantitative imaging tools to complement the limitation of noise encountered by high resolution fluorescence microscopy methods. Several cycles of fluorophore activation, imaging and deactivation produce a sequence of…

Quantitative Methods · Quantitative Biology 2012-02-03 Juliane Liepe , Federico Felizzi , Agata Pernus , Maria Hanulova

High-resolution medical images are beneficial for analysis but their acquisition may not always be feasible. Alternatively, high-resolution images can be created from low-resolution acquisitions using conventional upsampling methods, but…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Jörg Sander , Bob D. de Vos , Ivana Išgum

Lightsheet microscopy is a powerful 3-D imaging technique that addresses limitations of traditional optical and confocal microscopy but suffers from a low penetration depth and reduced image quality at greater depths. Multiview lightsheet…

Image and Video Processing · Electrical Eng. & Systems 2025-03-21 Marek Wodzinski , Henning Müller

Modern deep neural networks have shown remarkable performance in medical image classification. However, such networks either emphasize pixel-intensity features instead of fundamental anatomical structures (e.g., those encoded by topological…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Pengfei Gu , Huimin Li , Haoteng Tang , Dongkuan , Xu , Erik Enriquez , DongChul Kim , Bin Fu , Danny Z. Chen

Fourier Ptychographic Microscopy (FPM) is a computational imaging method that is able to super-resolve features beyond the diffraction-limit set by the objective lens of a traditional microscope. This is accomplished by using synthetic…

Signal Processing · Electrical Eng. & Systems 2019-04-09 Michael Kellman , Emrah Bostan , Michael Chen , Laura Waller

Super-resolution techniques overcome the diffraction-limit and get very high resolutions. A category of these techniques, e.g., STED achieves this by creating an illumination spot smaller than the Airy Disk. As a result, points are…

Image and Video Processing · Electrical Eng. & Systems 2019-11-20 Yaohua Xie

Intra-operative measurements of tissue shape and multi/ hyperspectral information have the potential to provide surgical guidance and decision making support. We report an optical probe based system to combine sparse hyperspectral…

Computer Vision and Pattern Recognition · Computer Science 2017-06-22 Jianyu Lin , Neil T. Clancy , Yang Hu , Ji Qi , Taran Tatla , Danail Stoyanov , Lena Maier-Hein , Daniel S. Elson

Ultrasound Localization Microscopy (ULM) is a non-invasive technique that allows for the imaging of micro-vessels in vivo, at depth and with a resolution on the order of ten microns. ULM is based on the sub-resolution localization of…

Image and Video Processing · Electrical Eng. & Systems 2025-10-17 Brice Rauby , Paul Xing , Jonathan Porée , Maxime Gasse , Jean Provost

Fluorescence microscopy is widely used in biological imaging, however scattering from tissues strongly limits its applicability to a shallow depth. In this work we adapt a methodology inspired from stellar speckle interferometry, and…