Related papers: Positronium Lifetime Imaging with the Biograph Vis…
Purpose: 44Sc has been successfully produced, synthesized, labeled and first-in-human studies were conducted some years ago. The decay properties of 44Sc, together with being close to a clinical implementation, make it an ideal candidate…
The objective of this work is to showcase the ortho-positronium lifetime as a probe for soft-tissue characterization. We employed positron annihilation lifetime spectroscopy to experimentally measure the three components of the positron…
Positronium imaging was recently proposed to image the properties of positronium atoms in the patient body. Positronium properties depend on the size of intramolecular voids and oxygen concentration; therefore, they deliver information…
Positronium Lifetime Imaging (PLI) extends positron emission tomography by using the lifetime of positronium atoms as a probe of tissue molecular architecture. In this work, we report the first PLI measurements performed with $^{52}$Mn and…
In living organisms the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of…
Background: Positronium lifetime imaging extends conventional positron emission tomography by using the time interval between positron emission and annihilation as an additional contrast mechanism. Voxel-wise lifetime estimation in fully…
The presence of tumor hypoxia is known to correlate with poor patient prognosis. Measurement of tissue oxygen concentration can be challenging, but recent advancements using positron annihilation lifetime spectroscopy (PALS) in…
Currently, the experimental uncertainty for the determination of the ortho-positronium (o-Ps) decay rate is at 150 ppm precision; this is two orders of magnitude lower than the theoretical one, at 1 ppm level. Here we propose a new proof of…
Background: After its first ex-vivo and in-vivo demonstration, Positronium Lifetime Imaging (PLI) has received considerable interest as a potential new diagnostic biomarker. High sensitivity Positron Emission Tomography (PET) systems are…
We develop a positronium imaging method for the Jagiellonian PET (J-PET) scanners based on the time-of-flight maximum likelihood expectation maximisation (TOF MLEM). The system matrix elements are calculated on-the-fly for the coincidences…
Electron antineutrinos are detected in organic liquid scintillator based neutrino experiments by means of the inverse beta decay, producing both a positron and a neutron. The positron may form a bound state together with an electron, called…
Positron lifetime spectra were measured in liquid water at temperatures between 0c and 50c. The long lifetime of ortho-positronium atoms (o-Ps) determined by electron pick-off in molecular substances decreases smoothly by 10% as the…
Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the…
A method for measuring the tensor polarization in a positronium (Ps) beam is proposed, which is based on the determination of the Ps lifetime as a function of the orientation of a homogeneous magnetic field. The dependence of the…
A detection system of the conventional PET tomograph is set-up to record data from e+ e- annihilation into two photons with energy of 511 keV, and it gives information on the density distribution of a radiopharmaceutical in the body of the…
Positron Annihilation Lifetime Spectroscopy (PALS) allows examining structure of materials in nano and sub-nanometer scale. This technique is based on the lifetime and intensity of ortho-positronium atoms in free volumes of given…
This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the $^{44}$Sc radionuclide. The $^{44}$Sc isotope was produced via the $^{44}$Ca(p, n)$^{44}$Sc nuclear reaction and used to…
Positron Emission Tomography (PET) is a crucial tool in medical imaging, particularly for diagnosing diseases like cancer and Alzheimer's. The advent of Positronium Lifetime Imaging (PLI) has opened new avenues for assessing the tissue…
One of the features of the triplet state of positronium (ortho-Positronium)atoms is its relatively longer lifetime when compared to the singlet states ofpositronium (para-Positronium) atoms. The most probable decay of ortho-Positronium is…
Samples of uterine leiomyomatis and normal tissues taken from patients after surgery were investigated using the Positron Annihilation Lifetime Spectroscopy (PALS). Significant differences in all PALS parameters between normal and diseased…