Ortho-positronium Lifetime For Soft-tissue Classification
Abstract
The objective of this work is to showcase the ortho-positronium lifetime as a probe for soft-tissue characterization. We employed positron annihilation lifetime spectroscopy to experimentally measure the three components of the positron annihilation lifetime para-positronium (p-Ps), positron, and ortho-positronium (o-Ps) for three types of porcine, non-fixated soft tissues ex vivo: adipose, hepatic, and muscle.Then, we benchmarked our measurements with X-ray phase-contrast imaging, which is the current state-of-the-art for soft-tissue analysis. We found that the o-Ps lifetime in adipose tissues (2.54+/-0.12) ns was approximately 20\% longer than in hepatic (2.04+/-0.09 ns) and muscle (2.03+/-0.12 ns) tissues .In addition, the separation between the measurements for adipose tissue and the other tissues was better from o-Ps lifetime measurement than from X-ray phase-contrast imaging. This experimental study proved that the o-Ps lifetime is a viable non-invasive probe for characterizing and classifying the different soft tissues. Specifically, o-Ps lifetime as a soft-tissue characterization probe had a strong sensitivity to the lipid content that can be potentially implemented in commercial positron emission tomography scanners that feature list-mode data acquisition.
Cite
@article{arxiv.2409.13102,
title = {Ortho-positronium Lifetime For Soft-tissue Classification},
author = {Ashish V. Avachat and Kholod H. Mahmoud and Anthony G. Leja and Jiajie J. Xu and Mark A. Anastasio and Mayandi Sivaguru and Angela Di Fulvio},
journal= {arXiv preprint arXiv:2409.13102},
year = {2024}
}