First ex-vivo positronium imaging of tissues with modular J-PET scanner using $^{44}$Sc radionuclide
Abstract
This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the Sc radionuclide. The Sc isotope was produced via the Ca(p, n)Sc nuclear reaction and used to perform positronium imaging of phantom composed of human adipose tissue, cardiac myxoma tissue, thrombi blood clot, and also porous polymer XAD4, and a certified reference material (CRM) made from fused silica. The experiment demonstrates the suitability of Sc as a positron source for positronium imaging. The performance of J-PET for positronium imaging with Sc was validated by proper reconstruction of the mean orthopositronium lifetime for CRM material and XAD-4 polymer. The mean ortho-positronium (oPs) lifetimes determined for adipose tissue, cardiac myxoma tissues and thrombi were consistent with results of previous experiments. The study highlights the potential Sc radionuclide for positronium lifetime imaging (PLI).
Keywords
Cite
@article{arxiv.2602.07580,
title = {First ex-vivo positronium imaging of tissues with modular J-PET scanner using $^{44}$Sc radionuclide},
author = {Karol Kubat and Manish Das and Sushil Sharma and Ermias Y. Beyene and Aleksander Bilewicz and Jarosław Choiński and Neha Chug and Catalina Curceanu and Eryk Czerwiński and Jakub Hajduga and Sharareh Jalali and Krzysztof Kacprzak and Tevfik Kaplanoglu and Łukasz Kapłon and Kamila Kasperska and Aleksander Khreptak and Grzegorz Korcyl and Tomasz Kozik and Deepak Kumar and Sumit Kumar Kundu and Anoop Kunimmal-Venadan and Bartosz Leszczyński and Edward Lisowski and Filip Lisowski and Justyna Mędrala-Sowa and Simbarashe Moyo and Wiktor Mryka and Szymon Niedźwiecki and Anand Pandey and Piyush Pandey and Szymon Parzych and Alessio Porcelli and Bartłomiej Rachwał and Martin Rädler and Magdalena Skurzok and Anna Stolarz and Tomasz Szumlak and Pooja Tanty and Keyvan Tayefi Ardebili and Satyam Tiwari and Kavya Valsan Eliyan and Rafał Walczak and Paweł Moskal and Ewa Ł. Stępień},
journal= {arXiv preprint arXiv:2602.07580},
year = {2026}
}
Comments
to be published in Zeitschrift f\"ur Medizinische Physik