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Semantic instance segmentation remains a challenging task. In this work we propose to tackle the problem with a discriminative loss function, operating at the pixel level, that encourages a convolutional network to produce a representation…

Computer Vision and Pattern Recognition · Computer Science 2017-08-10 Bert De Brabandere , Davy Neven , Luc Van Gool

One of the critical steps in improving accurate single neuron reconstruction from three-dimensional (3D) optical microscope images is the neuronal structure segmentation. However, they are always hard to segment due to the lack in quality.…

Image and Video Processing · Electrical Eng. & Systems 2021-01-25 Heng Wang , Yang Song , Chaoyi Zhang , Jianhui Yu , Siqi Liu , Hanchuan Peng , Weidong Cai

A major obstacle in instance segmentation is that existing methods often need many per-pixel labels in order to be effective. These labels require large human effort and for certain applications, such labels are not readily available. To…

Computer Vision and Pattern Recognition · Computer Science 2019-07-03 Issam H. Laradji , David Vazquez , Mark Schmidt

Accurate segmentation of blood vessels is essential for various clinical assessments and postoperative analyses. However, the inherent challenges of vascular imaging, such as sparsity, fine granularity, low contrast, data distribution…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Dongning Song , Weijian Huang , Jiarun Liu , Md Jahidul Islam , Hao Yang , Shanshan Wang

Accurate segmentation of tubular, network-like structures, such as vessels, neurons, or roads, is relevant to many fields of research. For such structures, the topology is their most important characteristic; particularly preserving…

Computer Vision and Pattern Recognition · Computer Science 2022-07-18 Suprosanna Shit , Johannes C. Paetzold , Anjany Sekuboyina , Ivan Ezhov , Alexander Unger , Andrey Zhylka , Josien P. W. Pluim , Ulrich Bauer , Bjoern H. Menze

Recently deep residual learning with residual units for training very deep neural networks advanced the state-of-the-art performance on 2D image recognition tasks, e.g., object detection and segmentation. However, how to fully leverage…

Computer Vision and Pattern Recognition · Computer Science 2016-08-23 Hao Chen , Qi Dou , Lequan Yu , Pheng-Ann Heng

This paper proposes a novel topological learning framework that integrates networks of different sizes and topology through persistent homology. Such challenging task is made possible through the introduction of a computationally efficient…

Neurons and Cognition · Quantitative Biology 2023-01-30 Tananun Songdechakraiwut , Moo K. Chung

Segmenting curvilinear structures in medical images is essential for analyzing morphological patterns in clinical applications. Integrating topological properties, such as connectivity, improves segmentation accuracy and consistency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Zhuangzhi Gao , Feixiang Zhou , He Zhao , Xiuju Chen , Xiaoxin Li , Qinkai Yu , Yitian Zhao , Alena Shantsila , Gregory Y. H. Lip , Eduard Shantsila , Yalin Zheng

Accurate and reliable image segmentation is an essential part of biomedical image analysis. In this paper, we consider the problem of biomedical image segmentation using deep convolutional neural networks. We propose a new end-to-end…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Amirhossein Dadashzadeh , Alireza Tavakoli Targhi

Whole brain segmentation is an important neuroimaging task that segments the whole brain volume into anatomically labeled regions-of-interest. Convolutional neural networks have demonstrated good performance in this task. Existing…

Image and Video Processing · Electrical Eng. & Systems 2021-11-01 Yeshu Li , Jonathan Cui , Yilun Sheng , Xiao Liang , Jingdong Wang , Eric I-Chao Chang , Yan Xu

Mapping the connectivity of neurons in the brain (i.e., connectomics) is a challenging problem due to both the number of connections in even the smallest organisms and the nanometer resolution required to resolve them. Because of this,…

Neurons and Cognition · Quantitative Biology 2014-09-08 Ting Zhao , Stephen M Plaza

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

Promoting the connectivity of curvilinear structures, such as neuronal processes in biomedical scans and blood vessels in CT images, remains a key challenge in semantic segmentation. Traditional pixel-wise loss functions, including…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Elyar Esmaeilzadeh , Ehsan Garaaghaji , Farzad Hallaji Azad , Doruk Oner

Medical image segmentation has been so far achieving promising results with Convolutional Neural Networks (CNNs). However, it is arguable that in traditional CNNs, its pooling layer tends to discard important information such as positions.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Tan Nguyen , Binh-Son Hua , Ngan Le

Voxel is an important format to represent geometric data, which has been widely used for 3D deep learning in shape analysis due to its generalization ability and regular data format. However, fine-grained tasks like part segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-09-05 Zongji Wang , Feng Lu

Segmentation in 3D scans is playing an increasingly important role in current clinical practice supporting diagnosis, tissue quantification, or treatment planning. The current 3D approaches based on convolutional neural networks usually…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Alexey Novikov , David Major , Maria Wimmer , Dimitrios Lenis , Katja Bühler

The emerging field of connectomics aims to unlock the mysteries of the brain by understanding the connectivity between neurons. To map this connectivity, we acquire thousands of electron microscopy (EM) images with nanometer-scale…

Quantitative Methods · Quantitative Biology 2016-04-04 Stephen M. Plaza , Stuart E. Berg

Blood vessel segmentation and -tracing are essential tasks in many medical imaging applications. Although numerous methods exist, the prevailing segment-then-fix paradigm is fundamentally limited regarding its suitability for modeling the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Rajalakshmi Palaniappan , Christoph Karg , Nemesio Navarro-Arambula , Peter Hirsch , Kristin Kraeker , Lisa Mais , Dagmar Kainmueller

Blood vessel networks in the brain play a crucial role in stroke research, where understanding their topology is essential for analyzing blood flow dynamics. However, extracting detailed topological vessel network information from…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Joël Mathys , Andreas Plesner , Jorel Elmiger , Roger Wattenhofer

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha