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Artificial intelligence (AI) is transforming scientific research, with explainable AI methods like concept-based models (CMs) showing promise for new discoveries. However, in molecular science, CMs are less common than black-box models like…

Artificial Intelligence · Computer Science 2024-12-17 Zimin Zhang , Qianli Wu , Botao Xia , Fang Sun , Ziniu Hu , Yizhou Sun , Shichang Zhang

The prevailing paradigm in AI for physical systems (scaling general-purpose foundation models toward universal multimodal reasoning) confronts a fundamental barrier at the control interface. Recent benchmarks show that even frontier…

Artificial Intelligence · Computer Science 2026-05-21 Yoon Pyo Lee , Samrendra Roy , Jay Yoo , Kazuma Kobayashi , Sajedul Talukder , Seid Koric , Souvik Chakraborty , Syed Bahauddin Alam

Metacognition is the concept of reasoning about an agent's own internal processes, and it has recently received renewed attention with respect to artificial intelligence (AI) and, more specifically, machine learning systems. This paper…

Artificial Intelligence · Computer Science 2025-08-11 Paulo Shakarian , Gerardo I. Simari , Nathaniel D. Bastian

The automation of chemical research through self-driving laboratories (SDLs) promises to accelerate scientific discovery, yet the reliability and granular performance of the underlying AI agents remain critical, under-examined challenges.…

Artificial Intelligence · Computer Science 2025-10-01 Gihan Panapitiya , Emily Saldanha , Heather Job , Olivia Hess

The backpropagation of error algorithm used to train deep neural networks has been fundamental to the successes of deep learning. However, it requires sequential backward updates and non-local computations, which make it challenging to…

Neural and Evolutionary Computing · Computer Science 2022-02-22 Beren Millidge , Tommaso Salvatori , Yuhang Song , Rafal Bogacz , Thomas Lukasiewicz

Simultaneously optimizing multiple, frequently conflicting, molecular properties is a key bottleneck in the development of novel therapeutics. Although a promising approach, the efficacy of multi-task learning is often compromised by…

Machine Learning · Computer Science 2025-10-01 Mason Minot , Gisbert Schneider

The pursuit of Artificial General Intelligence (AGI) is a central goal in language model development, in which consciousness-like processing could serve as a key facilitator. While current language models are not conscious, they exhibit…

Artificial Intelligence · Computer Science 2026-02-02 Hamid Reza Akbari , Mohammad Hossein Sameti , Amir M. Mansourian , Mohammad Hossein Rohban , Hossein Sameti

We introduce a new recurrent agent architecture and associated auxiliary losses which improve reinforcement learning in partially observable tasks requiring long-term memory. We employ a temporal hierarchy, using a slow-ticking recurrent…

Artificial Intelligence · Computer Science 2020-06-30 Adam Stooke , Valentin Dalibard , Siddhant M. Jayakumar , Wojciech M. Czarnecki , Max Jaderberg

With the development of foundation model (FM), agentic AI systems are getting more attention, yet their inherent issues like hallucination and poor reasoning, coupled with the frequent ad-hoc nature of system design, lead to unreliable and…

Artificial Intelligence · Computer Science 2026-01-28 Minh-Dung Dao , Quy Minh Le , Hoang Thanh Lam , Duc-Trong Le , Quoc-Viet Pham , Barry O'Sullivan , Hoang D. Nguyen

The rapid development and adoption of Generative AI (GAI) technology in the form of chatbots such as ChatGPT and Claude has greatly increased interest in agentic machines. This paper introduces the Autonomous Cognitive Entity (ACE) model, a…

Human-Computer Interaction · Computer Science 2023-11-02 David Shapiro , Wangfan Li , Manuel Delaflor , Carlos Toxtli

Cybersecurity decision-making increasingly occurs in environments characterized by uncertainty, partial observability, and adversarial manipulation, where heterogeneous signals from multiple sources are often incomplete, ambiguous, or…

Cryptography and Security · Computer Science 2026-05-01 Andrei Kojukhov , Arkady Bovshover

Artificial intelligence (AI) agents are emerging as transformative tools in drug discovery, with the ability to autonomously reason, act, and learn through complicated research workflows. Building on large language models (LLMs) coupled…

General AI Agents are increasingly recognized as foundational frameworks for the next generation of artificial intelligence, enabling complex reasoning, web interaction, coding, and autonomous research capabilities. However, current agent…

The field of Artificial Intelligence is undergoing a transition from Generative AI -- probabilistic generation of text and images -- to Agentic AI, in which autonomous systems execute actions within external environments on behalf of users.…

Artificial Intelligence · Computer Science 2026-03-02 Sheng Cao , Zhao Chang , Chang Li , Hannan Li , Liyao Fu , Ji Tang

Rule-based systems remain central in safety-critical domains but often struggle with scalability, brittleness, and goal misspecification. These limitations can lead to reward hacking and failures in formal verification, as AI systems tend…

Logic in Computer Science · Computer Science 2026-05-12 Zainab Rehan , Christian Medeiros Adriano , Sona Ghahremani , Holger Giese

Deep neural networks excel at image classification, but their performance is far less robust to input perturbations than human perception. In this work we explore whether this shortcoming may be partly addressed by incorporating…

Computer Vision and Pattern Recognition · Computer Science 2021-11-05 Bhavin Choksi , Milad Mozafari , Callum Biggs O'May , Benjamin Ador , Andrea Alamia , Rufin VanRullen

This paper presents a new learning algorithm, termed Deep Bi-directional Predictive Coding (DBPC) that allows developing networks to simultaneously perform classification and reconstruction tasks using the same weights. Predictive Coding…

Machine Learning · Computer Science 2023-05-31 Senhui Qiu , Saugat Bhattacharyya , Damien Coyle , Shirin Dora

Artificial intelligence (AI) and data science are transforming chemical research, yet few formal courses are tailored to synthetic and experimental chemists, who often face steep entry barriers due to limited coding experience and lack of…

Artificial Intelligence · Computer Science 2026-04-10 Zhiling Zheng

For the past decade, the trajectory of generative artificial intelligence (AI) has been dominated by a model-centric paradigm driven by scaling laws. Despite significant leaps in visual fidelity, this approach has encountered a ``usability…

Artificial Intelligence · Computer Science 2026-02-06 Jiaheng Liu , Yuanxing Zhang , Shihao Li , Xinping Lei

Agentic AI represents a transformative shift in artificial intelligence, but its rapid advancement has led to a fragmented understanding, often conflating modern neural systems with outdated symbolic models -- a practice known as conceptual…

Artificial Intelligence · Computer Science 2025-10-30 Mohamad Abou Ali , Fadi Dornaika