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Antibody-drug conjugate (ADC) has revolutionized the field of cancer treatment in the era of precision medicine due to their ability to precisely target cancer cells and release highly effective drug. Nevertheless, the realization of…

Machine Learning · Computer Science 2024-01-18 Liye Chen , Biaoshun Li , Yihao Chen , Mujie Lin , Shipeng Zhang , Chenxin Li , Yu Pang , Ling Wang

The combination of policy search and deep neural networks holds the promise of automating a variety of decision-making tasks. Model Predictive Control (MPC) provides robust solutions to robot control tasks by making use of a dynamical model…

Robotics · Computer Science 2021-05-11 Yunlong Song , Davide Scaramuzza

Top-down feedback in cortex is critical for guiding sensory processing, which has prominently been formalized in the theory of hierarchical predictive coding (hPC). However, experimental evidence for error units, which are central to the…

Neurons and Cognition · Quantitative Biology 2022-11-23 Fabian A. Mikulasch , Lucas Rudelt , Michael Wibral , Viola Priesemann

While pre-trained language model (PLM) fine-tuning has achieved strong performance in many NLP tasks, the fine-tuning stage can be still demanding in labeled data. Recent works have resorted to active fine-tuning to improve the label…

Computation and Language · Computer Science 2022-05-04 Yue Yu , Lingkai Kong , Jieyu Zhang , Rongzhi Zhang , Chao Zhang

Recent studies have highlighted the limitations of large language models in mathematical reasoning, particularly their inability to capture the underlying logic. Inspired by meta-learning, we propose that models should acquire not only…

Computation and Language · Computer Science 2024-12-19 Kejie Chen , Lin Wang , Qinghai Zhang , Renjun Xu

Backpropagation has rapidly become the workhorse credit assignment algorithm for modern deep learning methods. Recently, modified forms of predictive coding (PC), an algorithm with origins in computational neuroscience, have been shown to…

Neural and Evolutionary Computing · Computer Science 2023-04-07 Umais Zahid , Qinghai Guo , Zafeirios Fountas

Generating deep research reports requires large-scale information acquisition and the synthesis of insight-driven analysis, posing a significant challenge for current language models. Most existing approaches follow a plan-then-write…

Molecular property prediction and generative design via deep learning models has been the subject of intense research given its potential to accelerate development of new, high-performance materials. More recently, these workflows have been…

Artificial Intelligence · Computer Science 2024-12-16 Nathaniel H. Park , Tiffany J. Callahan , James L. Hedrick , Tim Erdmann , Sara Capponi

Arbitrary-precision integer multiplication is the core kernel of many applications in simulation, cryptography, etc. Existing acceleration of arbitrary-precision integer multiplication includes CPUs, GPUs, FPGAs, and ASICs. Among these…

Hardware Architecture · Computer Science 2023-09-22 Zhuoping Yang , Jinming Zhuang , Jiaqi Yin , Cunxi Yu , Alex K. Jones , Peipei Zhou

Cybersecurity is being fundamentally reshaped by foundation-model-based artificial intelligence. Large language models now enable autonomous planning, tool orchestration, and strategic adaptation at scale, challenging security architectures…

Cryptography and Security · Computer Science 2025-12-30 Tao Li , Quanyan Zhu

A large amount of recent research has the far-reaching goal of finding training methods for deep neural networks that can serve as alternatives to backpropagation (BP). A prominent example is predictive coding (PC), which is a…

Machine Learning · Computer Science 2022-11-08 Luca Pinchetti , Tommaso Salvatori , Yordan Yordanov , Beren Millidge , Yuhang Song , Thomas Lukasiewicz

Automatic workflow composition (AWC) is a relevant problem in automated machine learning (AutoML) that allows finding suitable sequences of preprocessing and prediction models together with their optimal hyperparameters. This problem can be…

Machine Learning · Computer Science 2024-02-29 Rafael Barbudo , Aurora Ramírez , José Raúl Romero

Predictive coding has emerged as an influential normative model of neural computation, with numerous extensions and applications. As such, much effort has been put into mapping PC faithfully onto the cortex, but there are issues that remain…

Neurons and Cognition · Quantitative Biology 2023-03-07 Siavash Golkar , Tiberiu Tesileanu , Yanis Bahroun , Anirvan M. Sengupta , Dmitri B. Chklovskii

Multi-agent systems (MAS) powered by large language models (LLMs) hold significant promise for solving complex decision-making tasks. However, the core process of collaborative decision-making (CDM) within these systems remains…

Artificial Intelligence · Computer Science 2025-08-19 Xuyang Zhao , Shiwan Zhao , Hualong Yu , Liting Zhang , Qicheng Li

Recent advances in general-purpose AI systems with attention-based transformers offer a potential window into how the neocortex and cerebellum, despite their relatively uniform circuit architectures, give rise to diverse functions and,…

Neurons and Cognition · Quantitative Biology 2025-12-03 Shogo Ohmae , Keiko Ohmae

We introduce Cognitive Kernel, an open-source agent system towards the goal of generalist autopilots. Unlike copilot systems, which primarily rely on users to provide essential state information (e.g., task descriptions) and assist users by…

Artificial Intelligence · Computer Science 2025-01-03 Hongming Zhang , Xiaoman Pan , Hongwei Wang , Kaixin Ma , Wenhao Yu , Dong Yu

Machine learning algorithms have achieved superhuman performance in specific complex domains. However, learning online from few examples and compositional learning for efficient generalization across domains remain elusive. In humans, such…

Neurons and Cognition · Quantitative Biology 2024-11-11 V. A. Aksyuk

Predictive processing has become an influential framework in cognitive sciences. This framework turns the traditional view of perception upside down, claiming that the main flow of information processing is realized in a top-down…

Robotics · Computer Science 2021-01-25 Alejandra Ciria , Guido Schillaci , Giovanni Pezzulo , Verena V. Hafner , Bruno Lara

In this paper, we present a novel information processing architecture for safe deep learning-based visual navigation of autonomous systems. The proposed information processing architecture is used to support a perceptual attention-based…

Robotics · Computer Science 2019-10-17 Keuntaek Lee , Gabriel Nakajima An , Viacheslav Zakharov , Evangelos A. Theodorou

Learning meaningful and general representations from unannotated speech that are applicable to a wide range of tasks remains challenging. In this paper we propose to use autoregressive predictive coding (APC), a recently proposed…

Audio and Speech Processing · Electrical Eng. & Systems 2020-01-28 Yu-An Chung , James Glass
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