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Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here…

Quantitative Methods · Quantitative Biology 2018-03-05 Christian Dansereau , Angela Tam , AmanPreet Badhwar , Sebastian Urchs , Pierre Orban , Pedro Rosa-Neto , Pierre Bellec

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

Machine Learning · Computer Science 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Dementia is a progressive cognitive syndrome with Alzheimer's disease (AD) as the leading cause. Conversation-based AD detection offers a cost-effective alternative to clinical methods, as language dysfunction is an early biomarker of AD.…

Computation and Language · Computer Science 2025-02-27 Arezo Shakeri , Mina Farmanbar , Krisztian Balog

Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker…

Machine Learning · Computer Science 2017-06-06 Murat Seckin Ayhan , Vijay Raghavan , Alzheimer's disease Neuroimaging Initiative

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease affecting 50 million people worldwide. Low-cost, accurate identification of key markers of AD is crucial for timely diagnosis and intervention. Language impairment is one…

Computation and Language · Computer Science 2025-05-27 Tingyu Mo , Jacqueline C. K. Lam , Victor O. K. Li , Lawrence Y. L. Cheung

Alzheimers disease is a deadly neurological condition, impairing important memory and brain functions. Alzheimers disease promotes brain shrinkage, ultimately leading to dementia. Dementia diagnosis typically takes 2.8 to 4.4 years after…

Alzheimer's Disease is the most common form of dementia. Automatic detection from speech could help to identify symptoms at early stages, so that preventive actions can be carried out. This research is a contribution to the ADReSSo…

Computation and Language · Computer Science 2021-11-01 Joan Codina-Filbà , Guillermo Cámbara , Jordi Luque , Mireia Farrús

We present an approach to automatic detection of Alzheimer's type dementia based on characteristics of spontaneous spoken language dialogue consisting of interviews recorded in natural settings. The proposed method employs additive logistic…

Audio and Speech Processing · Electrical Eng. & Systems 2018-11-27 Saturnino Luz , Sofia de la Fuente , Pierre Albert

One of the most prevalent symptoms among the elderly population, dementia, can be detected by classifiers trained on linguistic features extracted from narrative transcripts. However, these linguistic features are impacted in a similar but…

Machine Learning · Computer Science 2019-09-10 Zining Zhu , Jekaterina Novikova , Frank Rudzicz

In light of the growing proportion of older individuals in our society, the timely diagnosis of Alzheimer's disease has become a crucial aspect of healthcare. In this paper, we propose a non-invasive and cost-effective detection method…

Human-Computer Interaction · Computer Science 2025-01-03 Tian Zheng , Xurong Xie , Xiaolan Peng , Hui Chen , Feng Tian

Pathological speech analysis has been of interest in the detection of certain diseases like depression and Alzheimer's disease and attracts much interest from researchers. However, previous pathological speech analysis models are commonly…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-08 Fei Yang , Xuenan Xu , Mengyue Wu , Kai Yu

Alzheimer's dementia (AD) affects memory, thinking, and language, deteriorating person's life. An early diagnosis is very important as it enables the person to receive medical help and ensure quality of life. Therefore, leveraging…

Machine Learning · Computer Science 2023-04-06 Michail Chatzianastasis , Loukas Ilias , Dimitris Askounis , Michalis Vazirgiannis

Interactive cognitive assessment tools may be valuable for doctors and therapists to reduce costs and improve quality in healthcare systems. Use cases and scenarios include the assessment of dementia. In this paper, we present our approach…

Human-Computer Interaction · Computer Science 2018-10-12 Daniel Sonntag

Parkinson's disease is a progressive neurodegenerative disorder affecting motor and non-motor functions, with speech impairments among its earliest symptoms. Speech impairments offer a valuable diagnostic opportunity, with machine learning…

Machine Learning · Computer Science 2025-04-25 Lorenzo Simone , Mauro Giuseppe Camporeale , Vito Marco Rubino , Vincenzo Gervasi , Giovanni Dimauro

Agitation is one of the most prevalent symptoms in people with dementia (PwD) that can place themselves and the caregiver's safety at risk. Developing objective agitation detection approaches is important to support health and safety of PwD…

Machine Learning · Computer Science 2023-08-16 Zhidong Meng , Andrea Iaboni , Bing Ye , Kristine Newman , Alex Mihailidis , Zhihong Deng , Shehroz S. Khan

Joint models initially dedicated to a single longitudinal marker and a single time-to-event need to be extended to account for the rich longitudinal data of cohort studies. Multiple causes of clinical progression are indeed usually…

Applications · Statistics 2016-01-26 Cécile Proust-Lima , Jean-François Dartigues , Hélène Jacqmin-Gadda

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Early detection of AD is crucial for effective intervention and treatment. In this paper, we propose a novel approach…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-29 Yu Pu , Wei-Qiang Zhang

About 5-8% of individuals over the age of 60 have dementia. With our ever-aging population this number is likely to increase, making dementia one of the most important threats to public health in the 21st century. Given the phenotypic…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Magnus Magnusson , Askell Love , Lotta M. Ellingsen

Dementia is a syndrome characterised by the decline of different cognitive abilities. Alzheimer's Disease (AD) is the most common dementia affecting cognitive domains such as memory and learning, perceptual-motion or executive function.…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Juan Manuel Fernández Montenegro

Alzheimer's dementia (AD) is a neurodegenerative disorder with cognitive decline that commonly impacts language ability. This work extends the paired perplexity approach to detecting AD by using a recent large language model (LLM), the…

Computation and Language · Computer Science 2025-06-12 Yao Xiao , Heidi Christensen , Stefan Goetze
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