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Alzheimer's disease (AD) is a common form of dementia that severely impacts patient health. As AD impairs the patient's language understanding and expression ability, the speech of AD patients can serve as an indicator of this disease. This…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-07 Hongmin Cai , Xiaoke Huang , Zhengliang Liu , Wenxiong Liao , Haixing Dai , Zihao Wu , Dajiang Zhu , Hui Ren , Quanzheng Li , Tianming Liu , Xiang Li

The speech of people with Parkinson's Disease (PD) has been shown to hold important clues about the presence and progression of the disease. We investigate the factors based on which humans experts make judgments of the presence of disease…

As other neurodegenerative diseases, Alzheimer's disease, the most frequent dementia in the elderly, is characterized by multiple progressive impairments in the brain structure and in clinical functions such as cognitive functioning and…

Methodology · Statistics 2019-10-21 Cécile Proust-Lima , Viviane Philipps , Jean-François Dartigues

This Working Note summarizes the participation of the DS@GT team in two eRisk 2025 challenges. For the Pilot Task on conversational depression detection with large language-models (LLMs), we adopted a prompt-engineering strategy in which…

Computation and Language · Computer Science 2025-07-16 Anthony Miyaguchi , David Guecha , Yuwen Chiu , Sidharth Gaur

Speech intelligibility assessment plays an important role in the therapy of patients suffering from pathological speech disorders. Automatic and objective measures are desirable to assist therapists in their traditionally subjective and…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Tobias Weise , Philipp Klumpp , Kubilay Can Demir , Andreas Maier , Elmar Noeth , Bjoern Heismann , Maria Schuster , Seung Hee Yang

The automatic, sensor-based assessment of challenging behavior of persons with dementia is an important task to support the selection of interventions. However, predicting behaviors like apathy and agitation is challenging due to the large…

Machine Learning · Computer Science 2024-08-13 Maximilian Popko , Sebastian Bader , Stefan Lüdtke , Thomas Kirste

Creating controlled methods to simulate neurodegeneration in artificial intelligence (AI) is crucial for applications that emulate brain function decline and cognitive disorders. We use IQ tests performed by Large Language Models (LLMs)…

Computation and Language · Computer Science 2024-03-19 Antonios Alexos , Yu-Dai Tsai , Ian Domingo , Maryam Pishgar , Pierre Baldi

Behavioral and Psychological Symptoms of Dementia (BPSD) impact dementia care substantially, affecting both patients and caregivers. Effective management and early detection of BPSD are crucial to reduce the stress and burden on caregivers…

Signal Processing · Electrical Eng. & Systems 2024-10-25 Benny Wei-Yun Hsu , Yu-Ming Chen , Yuan-Han Yang , Vincent S. Tseng

Speech disorders often occur at the early stage of Parkinson's disease (PD). The speech impairments could be indicators of the disorder for early diagnosis, while motor symptoms are not obvious. In this study, we constructed a new speech…

Audio and Speech Processing · Electrical Eng. & Systems 2021-06-01 Hao Fang , Chen Gong , Chen Zhang , Yanan Sui , Luming Li

Depression is one of the leading causes of disability worldwide, posing a severe burden on individuals, healthcare systems, and society at large. Recent advancements in Large Language Models (LLMs) have shown promise in addressing mental…

Computation and Language · Computer Science 2025-02-11 Shiyu Teng , Jiaqing Liu , Rahul Kumar Jain , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-wei Chen

The large language models have achieved superior performance on various natural language tasks. One major drawback of such approaches is they are resource-intensive in fine-tuning new datasets. Soft-prompt tuning presents a…

Computation and Language · Computer Science 2023-10-30 Guoxin Chen , Yiming Qian , Bowen Wang , Liangzhi Li

Current automatic depression detection systems provide predictions directly without relying on the individual symptoms/items of depression as denoted in the clinical depression rating scales. In contrast, clinicians assess each item in the…

With people living longer than ever, the number of cases with dementia such as Alzheimer's disease increases steadily. It affects more than 46 million people worldwide, and it is estimated that in 2050 more than 100 million will be…

Multimedia · Computer Science 2021-01-20 Mariona Caros , Maite Garolera , Petia Radeva , Xavier Giro-i-Nieto

Early detection is crucial for timely intervention aimed at preventing and slowing the progression of neurocognitive disorder (NCD), a common and significant health problem among the aging population. Recent evidence has suggested that…

Computation and Language · Computer Science 2025-06-11 Yuejiao Wang , Xianmin Gong , Xixin Wu , Patrick Wong , Hoi-lam Helene Fung , Man Wai Mak , Helen Meng

The detection of perceived prominence in speech has attracted approaches ranging from the design of linguistic knowledge-based acoustic features to the automatic feature learning from suprasegmental attributes such as pitch and intensity…

Computation and Language · Computer Science 2021-10-28 Mithilesh Vaidya , Kamini Sabu , Preeti Rao

Dementia is characterized by a decline in memory and thinking that is significant enough to impair function in activities of daily living. Patients seen in dementia specialty clinics are highly heterogeneous with a variety of different…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Zachary Abrams , Suzanne Schindler , Nupur Ghoshal , Philip Payne

A few million words suffice for children to acquire language. Yet, the brain mechanisms underlying this unique ability remain poorly understood. To address this issue, we investigate neural activity recorded from over 7,400 electrodes…

The global prevalence of dementia is projected to double by 2050, highlighting the urgent need for scalable diagnostic tools. This study utilizes digital cognitive tasks with eye-tracking data correlated with memory processes to distinguish…

Human-Computer Interaction · Computer Science 2025-08-28 Tomás Silva Santos Rocha , Anastasiia Mikhailova , Moreno I. Coco , José Santos-Victor

This paper presents a macroscopic approach to automatic detection of speech sound disorder (SSD) in child speech. Typically, SSD is manifested by persistent articulation and phonological errors on specific phonemes in the language. The…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-30 Si-Ioi Ng , Cymie Wing-Yee Ng , Jiarui Wang , Tan Lee

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing…

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