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Sparse autoencoders (SAEs) enable feature-level mechanistic interpretability and activation steering in large language models (LLMs), but SAE-based language control remains unreliable in multilingual settings: most SAEs are trained on…

Computation and Language · Computer Science 2026-05-25 Yusser Al Ghussin , Daniil Gurgurov , Tanja Baeumel , Josef van Genabith , Patrick Schramowski , Simon Ostermann

Identifying the features learned by neural networks is a core challenge in mechanistic interpretability. Sparse autoencoders (SAEs), which learn a sparse, overcomplete dictionary that reconstructs a network's internal activations, have been…

Machine Learning · Computer Science 2024-05-27 Dan Braun , Jordan Taylor , Nicholas Goldowsky-Dill , Lee Sharkey

Modern large-scale Pre-trained Language Models (PLMs) have achieved tremendous success on a wide range of downstream tasks. However, most of the LM pre-training objectives only focus on text reconstruction, but have not sought to learn…

Computation and Language · Computer Science 2022-10-28 Liliang Ren , Zixuan Zhang , Han Wang , Clare R. Voss , Chengxiang Zhai , Heng Ji

Large language models (LLMs) encode a diverse range of linguistic features within their latent representations, which can be harnessed to steer their output toward specific target characteristics. In this paper, we modify the internal…

Computation and Language · Computer Science 2025-02-27 Sumanta Bhattacharyya , Pedram Rooshenas

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Large Language Models (LLMs) frequently exhibit strong translation abilities, even without task-specific fine-tuning. However, the internal mechanisms governing this innate capability remain largely opaque. To demystify this process, we…

Computation and Language · Computer Science 2026-01-19 Xinwei Wu , Heng Liu , Xiaohu Zhao , Yuqi Ren , Linlong Xu , Longyue Wang , Deyi Xiong , Weihua Luo , Kaifu Zhang

RFdiffusion is a popular and well-established model for generation of protein structures. However, this generative process offers limited insight into its internal representations and how they contribute to the final protein structure.…

Quantitative Methods · Quantitative Biology 2025-12-01 Wojciech Zarzecki , Paulina Szymczak , Ewa Szczurek , Kamil Deja

The ability of large language models (LLMs) to follow instructions is crucial for their practical applications, yet the underlying mechanisms remain poorly understood. This paper presents a novel framework that leverages sparse autoencoders…

Machine Learning · Computer Science 2025-02-18 Zirui He , Haiyan Zhao , Yiran Qiao , Fan Yang , Ali Payani , Jing Ma , Mengnan Du

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Studying protein mutations within amino acid sequences holds tremendous significance in life sciences. Protein language models (PLMs) have demonstrated strong capabilities in broad biological applications. However, due to architectural…

Machine Learning · Computer Science 2024-10-31 Yizhen Luo , Zikun Nie , Massimo Hong , Suyuan Zhao , Hao Zhou , Zaiqing Nie

At the intersection of the rapidly growing biological data landscape and advancements in Natural Language Processing (NLP), protein language models (PLMs) have emerged as a transformative force in modern research. These models have achieved…

Biomolecules · Quantitative Biology 2025-02-12 Lei Wang , Xudong Li , Han Zhang , Jinyi Wang , Dingkang Jiang , Zhidong Xue , Yan Wang

Sparse Autoencoders (SAEs) aim to decompose the activation space of large language models (LLMs) into human-interpretable latent directions or features. As we increase the number of features in the SAE, hierarchical features tend to split…

Computation and Language · Computer Science 2025-11-18 David Chanin , James Wilken-Smith , Tomáš Dulka , Hardik Bhatnagar , Satvik Golechha , Joseph Bloom

Identification of protein-protein interactions (PPIs) helps derive cellular mechanistic understanding, particularly in the context of complex conditions such as neurodegenerative disorders, metabolic syndromes, and cancer. Large Language…

Machine Learning · Computer Science 2025-08-18 Sanket Jantre , Tianle Wang , Gilchan Park , Kriti Chopra , Nicholas Jeon , Xiaoning Qian , Nathan M. Urban , Byung-Jun Yoon

The evaluation of large language models (LLMs) relies heavily on standardized benchmarks. These benchmarks provide useful aggregated metrics for a given capability, but those aggregated metrics can obscure (i) particular sub-areas where the…

Computation and Language · Computer Science 2025-12-25 Matyas Bohacek , Nino Scherrer , Nicholas Dufour , Thomas Leung , Christoph Bregler , Stephanie C. Y. Chan

While Large Language Models (LLMs) have achieved strong performance across many NLP tasks, their opaque internal mechanisms hinder trustworthiness and safe deployment. Existing surveys in explainable AI largely focus on post-hoc explanation…

Computation and Language · Computer Science 2026-04-21 Yutong Gao , Qinglin Meng , Yuan Zhou , Liangming Pan

Protein language models (PLMs) learn probability distributions over natural protein sequences. By learning from hundreds of millions of natural protein sequences, protein understanding and design capabilities emerge. Recent works have shown…

Quantitative Methods · Quantitative Biology 2026-02-27 Timothy Fei Truong , Tristan Bepler

Large language models (LLMs) are increasingly used in emotionally sensitive human-AI applications, yet little is known about how emotion recognition is internally represented. In this work, we investigate the internal mechanisms of emotion…

Computation and Language · Computer Science 2026-04-29 Bangzhao Shu , Arinjay Singh , Mai ElSherief

Large Language Models (LLMs) are becoming increasingly popular in pervasive computing due to their versatility and strong performance. However, despite their ubiquitous use, the exact mechanisms underlying their outstanding performance…

Computation and Language · Computer Science 2026-02-02 Alhassan Abdelhalim , Janick Edinger , Sören Laue , Michaela Regneri

Language Models (LMs) excel in understanding textual descriptions of proteins, as evident in biomedical question-answering tasks. However, their capability falters with raw protein data, such as amino acid sequences, due to a deficit in…

Quantitative Methods · Quantitative Biology 2024-05-22 Zhiyuan Liu , An Zhang , Hao Fei , Enzhi Zhang , Xiang Wang , Kenji Kawaguchi , Tat-Seng Chua

Emotion recognition from speech is a challenging task that requires capturing both linguistic and paralinguistic cues, with critical applications in human-computer interaction and mental health monitoring. Recent works have highlighted the…

Audio and Speech Processing · Electrical Eng. & Systems 2025-08-21 Hugo Thimonier , Antony Perzo , Renaud Seguier