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Neural network pruning can be formulated as a combinatorial optimization problem, yet most existing approaches rely on greedy heuristics that ignore complex interactions between filters. Formal optimization methods such as Quadratic…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Osama Orabi , Artur Zagitov , Hadi Salloum , Viktor A. Lobachev , Kasymkhan Khubiev , Yaroslav Kholodov

The protein-protein interactions (PPIs) are crucial for understanding the majority of cellular processes. PPIs play important role in gene transcription regulation, cellular signaling, molecular basis of immune response and more. Moreover,…

Biomolecules · Quantitative Biology 2016-05-31 Maciej Pawel Ciemny , Mateusz Kurcinski , Andrzej Kolinski , Sebastian Kmiecik

Quadratic unconstrained binary optimization (QUBO) is the mathematical formalism for phrasing and solving a class of optimization problems that are combinatorial in nature. Due to their natural equivalence with the two dimensional Ising…

We introduce the quadratic balanced optimization problem (QBOP) which can be used to model equitable distribution of resources with pairwise interaction. QBOP is strongly NP-hard even if the family of feasible solutions has a very simple…

Optimization and Control · Mathematics 2013-08-15 Abraham P. Punnen , Sara Taghipour , Daniel Karapetyan , Bishnu Bhattacharyya

Problems related to wavelength assignment (WA) in optical communications networks involve allocating transmission wavelengths for known transmission paths between nodes that minimize a certain objective function, for example, the total…

This paper presents a generalization of a method allowing the transformation of the Elliptic Curve Discrete Logarithm Problem (ECDLP) over prime fields to the Quadratic Unconstrained Binary Optimization (QUBO) problem. The original method…

Cryptography and Security · Computer Science 2024-10-14 Łukasz Dzierzkowski

In finance, assessing the creditworthiness of loan applicants requires lenders to cluster borrowers using rating scales. Financial institutions must define the scales in compliance with strict institutional constraints, resulting in solving…

Combinatorial optimization problems, integral to various scientific and industrial applications, often vary significantly in their complexity and computational difficulty. Transforming such problems into Quadratic Unconstrained Binary…

Quantum Physics · Physics 2024-04-04 Thore Gerlach , Sascha Mücke

Qubit-efficient optimization studies how large combinatorial problems can be addressed with quantum circuits whose width is far smaller than the number of logical variables. In quadratic unconstrained binary optimization (QUBO), objective…

Quantum Physics · Physics 2026-01-13 Gordon Ma , Dimitris G. Angelakis

Quantum computing holds the potential for quantum advantage in optimization problems, which requires advances in quantum algorithms and hardware specifications. Adiabatic quantum optimization is conceptually a valid solution that suffers…

Quantum annealing is a promising approach for solving combinatorial optimization problems. However, its performance is often limited by the overhead of additional qubits required for embedding logical QUBO models onto quantum annealers.…

Quantum Physics · Physics 2026-01-27 Kohei Suda , Soshun Naito , Yoshihiko Hasegawa

Molecular docking is a crucial phase in drug discovery, involving the precise determination of the optimal spatial arrangement between two molecules when they bind. The such analysis, the 3D structure of molecules is a fundamental…

Quantum Physics · Physics 2024-03-04 Arit Kumar Bishwas , Arish Pitchai , Anuraj Som

We propose a quadratic unconstrained binary optimization (QUBO) formulation of rectified linear unit (ReLU) type functions. Different from the q-loss function proposed by Denchev et al. (2012), a simple discussion based on the Legendre…

Quantum Physics · Physics 2019-04-08 Go Sato , Makiko Konoshima , Takuya Ohwa , Hirotaka Tamura , Jun Ohkubo

We propose a solution approach for the problem (P) of minimizing an unconstrained binary polynomial optimization problem. We call this method PQCR (Polynomial Quadratic Convex Reformulation). The resolution is based on a 3-phase method. The…

Data Structures and Algorithms · Computer Science 2019-01-24 Sourour Elloumi , Amélie Lambert , Arnaud Lazare

The Travelling Salesman Problem (TSP) is an important combinatorial optimisation problem, and is usually solved on a quantum computer using a Quadratic Unconstrained Binary Optimisation (QUBO) formulation or a Higher Order Binary…

Quantum Physics · Physics 2024-06-21 Daniel Goldsmith , Joe Day-Evans

We use exact enumeration to characterize the solutions of quadratic unconstrained binary optimization problems of less than 21 variables in terms of their distributions of Hamming distances to close-by solutions. We also perform experiments…

Quantum Physics · Physics 2025-11-04 Vrinda Mehta , Fengping Jin , Kristel Michielsen , Hans De Raedt

As consequences of disruptions in railway traffic affect passenger experience/satisfaction, appropriate rerouting and/or rescheduling is necessary. These problems are known to be NP-hard, given the numerous restrictions of traffic nature.…

Emerging Technologies · Computer Science 2022-10-06 Krzysztof Domino , Akash Kundu , Özlem Salehi , Krzysztof Krawiec

To tackle combinatorial optimization problems using an Ising machine, the objective function and constraints must be mapped onto a quadratic unconstrained binary optimization (QUBO) model. While QUBO involves binary variables, combinatorial…

Statistical Mechanics · Physics 2025-01-22 Shuta Kikuchi , Kotaro Takahashi , Shu Tanaka

We aim to advance the state-of-the-art in Quadratic Unconstrained Binary Optimization formulation with a focus on cryptography algorithms. As the minimal QUBO encoding of the linear constraints of optimization problems emerges as the…

Cryptography and Security · Computer Science 2026-04-16 Gregory Morse , Tamás Kozsik , Oskar Mencer , Peter Rakyta

Quantum adiabatic evolution is perceived as useful for binary quadratic programming problems that are a priori unconstrained. For constrained problems, it is a common practice to relax linear equality constraints as penalty terms in the…

Optimization and Control · Mathematics 2018-02-13 Pooya Ronagh , Brad Woods , Ehsan Iranmanesh