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We propose a new kernel that quantifies success for the task of computing a core-periphery partition for an undirected network. Finding the associated optimal partitioning may be expressed in the form of a quadratic unconstrained binary…

Social and Information Networks · Computer Science 2022-01-06 Catherine F. Higham , Desmond J. Higham , Francesco Tudisco

In this paper, we consider the computational protein design (CPD) problem, which is usually modeled as a 0/1 programming and is extremely challenging due to its combinatorial properties. We propose an efficient algorithm for solving it.…

Optimization and Control · Mathematics 2024-12-30 Yukai Zheng , Weikun Chen , Qingna Li

The Steiner Tree Problem (STP) is a well-known NP-hard combinatorial optimization problem, which has wide applications in network design, integrated circuit layout, bioinformatics, and other fields. However, traditional algorithms often…

Quantum Physics · Physics 2026-03-05 Dan Li , Xiang-Hui Wu , Ji-Rong Liu

This study proposes a novel method for simplifying inequality constraints in Higher-Order Binary Optimization (HOBO) formulations. The proposed method addresses challenges associated with Quadratic Unconstrained Binary Optimization (QUBO)…

Optimization and Control · Mathematics 2025-01-22 Yuichiro Minato

We consider the problem of computing a sparse binary representation of an image. To be precise, given an image and an overcomplete, non-orthonormal basis, we aim to find a sparse binary vector indicating the minimal set of basis vectors…

Neural and Evolutionary Computing · Computer Science 2023-11-28 Kyle Henke , Elijah Pelofske , Georg Hahn , Garrett T. Kenyon

Several combinatorial optimization problems can be solved with NISQ devices once that a corresponding quadratic unconstrained binary optimization (QUBO) form is derived. The aim of this work is to drastically reduce the variables needed for…

Quantum Physics · Physics 2026-02-25 Dario De Santis , Salvatore Tirone , Stefano Marmi , Vittorio Giovannetti

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

The prospect of quantum solutions for complicated optimization problems is contingent on mapping the original problem onto a tractable quantum energy landscape, e.g. an Ising-type Hamiltonian. Subsequently, techniques like adiabatic…

Quantum Physics · Physics 2025-10-17 Sebastian Egginger , Kristina Kirova , Sonja Bruckner , Stefan Hillmich , Richard Kueng

Many artificial intelligence (AI) problems naturally map to NP-hard optimization problems. This has the interesting consequence that enabling human-level capability in machines often requires systems that can handle formally intractable…

Quantum Physics · Physics 2009-09-29 Hartmut Neven , Geordie Rose , William G. Macready

Modern quantum annealers can find high-quality solutions to combinatorial optimisation objectives given as quadratic unconstrained binary optimisation (QUBO) problems. Unfortunately, obtaining suitable QUBO forms in computer vision remains…

The unconstrained binary quadratic programming (UBQP) problem is a class of problems of significant importance in many practical applications, such as in combinatorial optimization, circuit design, and other fields. The positive…

Optimization and Control · Mathematics 2024-08-12 Xinyue Huo , Ran Gu

We present a novel quantum optimization-based route compression technique that significantly reduces storage requirements compared to conventional methods. Route optimization systems face critical challenges in efficiently storing selected…

Quantum Physics · Physics 2025-04-07 Shunsuke Sotobayashi , Yuichiro Minato , Takao Tomono

Optimization problems associated with the interaction of linked particles are at the heart of polymer science, protein folding and other important problems in the physical sciences. In this review we explain how to recast these problems as…

We present a classical algorithm to find approximate solutions to instances of quadratic unconstrained binary optimisation. The algorithm can be seen as an analogue of quantum annealing under the restriction of a product state space, where…

Quantum Physics · Physics 2023-02-14 Joseph Bowles , Alexandre Dauphin , Patrick Huembeli , José Martinez , Antonio Acín

Quantum computations are very important branch of modern cryptology. According to the number of working physical qubits available in general-purpose quantum computers and in quantum annealers, there is no coincidence, that nowadays quantum…

Cryptography and Security · Computer Science 2024-09-30 Michał Wroński , Mateusz Leśniak

Ising machines, including quantum annealing machines, are promising next-generation computers for combinatorial optimization problems. However, due to hardware limitations, most Ising-type hardware can only solve objective functions…

Statistical Mechanics · Physics 2025-10-29 Kazuki Ikeuchi , Yoshiki Matsuda , Shu Tanaka

Constrained combinatorial optimization problems are frequently reformulated as quadratic unconstrained binary optimization (QUBO) models in order to leverage emerging quantum optimization algorithms such as the Variational Quantum…

Quantum Physics · Physics 2026-04-23 Xin Wei Lee , Hoong Chuin Lau

In this paper, we introduce three QUBO (Quadratic Unconstrained Binary Optimization) relaxations for the sparsest $k$-subgraph (SkS) problem: a quadratic penalty relaxation, a Lagrangian relaxation, and an augmented Lagrangian relaxation.…

Optimization and Control · Mathematics 2025-09-11 Omkar Bihani , Roman Kužel , Janez Povh , Dunja Pucher

A novel algorithm to solve the quadratic programming problem over ellipsoids is proposed. This is achieved by splitting the problem into two optimisation sub-problems, quadratic programming over a sphere and orthogonal projection. Next, an…

Optimization and Control · Mathematics 2017-11-15 Anh-Huy Phan , Masao Yamagishi , Danilo Mandic , Andrzej Cichocki

Protein folding, which dictates the protein structure from its amino acid sequence, is half a century old problem of biology. The function of the protein correlates with its structure, emphasizing the need of understanding protein folding…

Quantum Physics · Physics 2025-01-03 Jaya Vasavi P , Soham Bopardikar , Avinash D , Ashwini K , Kalyan Dasgupta , Sanjib Senapati
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