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This paper presents a method of reconstruction a primary structure of a protein that folds into a given geometrical shape. This method predicts the primary structure of a protein and restores its linear sequence of amino acids in the…

Quantitative Methods · Quantitative Biology 2017-01-04 Andrii Riazanov , Mikhail Karasikov , Sergei Grudinin

We propose a quantum-assisted framework for solving constrained finite-horizon nonlinear optimal control problems using a barrier Sequential Quadratic Programming (SQP) approach. Within this framework, a quantum subroutine is incorporated…

Quantum Physics · Physics 2025-10-22 Nahid Binandeh Dehaghani , Rafal Wisniewski , A. Pedro Aguiar

We propose and analyze a set of variational quantum algorithms for solving quadratic unconstrained binary optimization problems where a problem consisting of $n_c$ classical variables can be implemented on $\mathcal O(\log n_c)$ number of…

Protein folding processes are a vital aspect of molecular biology that is hard to simulate with conventional computers. Quantum algorithms have been proven superior for certain problems and may help tackle this complex life science…

Quantum Physics · Physics 2024-09-11 Hanna Linn , Isak Brundin , Laura García-Álvarez , Göran Johansson

We present a quantum-inspired tensor network algorithm for solving tridiagonal Quadratic Unconstrained Binary Optimization (QUBO) problems and quadratic unconstrained discrete optimization (QUDO) problems. We also solve the more general…

In the field of quantum computing, combinatorial optimization problems are typically addressed using QUBO (Quadratic Unconstrained Binary Optimization) solvers. However, these solvers are often insufficient for tackling higher-order…

Quantum Physics · Physics 2024-07-24 Yuichiro Minato

Variational Quantum Algorithms (VQAs) provide a promising framework for tackling complex optimization problems on near-term quantum hardware. Here, we demonstrate that hybrid qubit--qumode quantum devices offer an efficient route to solving…

Particle swarm optimization is used in several combinatorial optimization problems. In this work, particle swarms are used to solve quadratic programming problems with quadratic constraints. The approach of particle swarms is an example for…

Artificial Intelligence · Computer Science 2014-07-24 Deepak Kumar , A G Ramakrishnan

Formulation symmetry in mixed-integer programming (MIP) can hinder solver performance by inducing redundant search, but detecting such symmetries is also a significant computational challenge. This paper explores the potential for quantum…

Optimization and Control · Mathematics 2025-12-18 Alexander While , Chen Chen

Charged particle reconstruction or track reconstruction is one of the most crucial components of pattern recognition in high-energy collider physics. It is known to entail enormous consumption of computing resources, especially when the…

Quantum Physics · Physics 2024-09-02 Hideki Okawa , Qing-Guo Zeng , Xian-Zhe Tao , Man-Hong Yung

Many fundamental problems in data mining can be reduced to one or more NP-hard combinatorial optimization problems. Recent advances in novel technologies such as quantum and quantum-inspired hardware promise a substantial speedup for…

Machine Learning · Computer Science 2022-01-10 Osman Asif Malik , Hayato Ushijima-Mwesigwa , Arnab Roy , Avradip Mandal , Indradeep Ghosh

We introduce parity quantum optimization with the aim of solving optimization problems consisting of arbitrary $k$-body interactions and side conditions using planar quantum chip architectures. The method introduces a decomposition of the…

We show that the NP-hard quadratic unconstrained binary optimization (QUBO) problem on a graph $G$ can be solved using an adiabatic quantum computer that implements an Ising spin-1/2 Hamiltonian, by reduction through minor-embedding of $G$…

Quantum Physics · Physics 2009-07-16 Vicky Choi

We present a heuristic algorithm designed to solve Quadratic Unconstrained Binary Optimization (QUBO) problems efficiently. The algorithm, referred to as IC-D2S, leverages a hybrid approach using Ising and classical machines to address very…

Hardware Architecture · Computer Science 2025-02-20 Armin Abdollahi , Mehdi Kamal , Massoud Pedram

The vehicle routing problem with time windows (VRPTW) is a common optimization problem faced within the logistics industry. In this work, we explore the use of a previously-introduced qubit encoding scheme to reduce the number of binary…

Quantum Physics · Physics 2023-09-20 Ioannis D. Leonidas , Alexander Dukakis , Benjamin Tan , Dimitris G. Angelakis

Quantum annealing offers a promising paradigm for solving NP-hard combinatorial optimization problems, but its practical application is severely hindered by two challenges: the complex, manual process of translating problem descriptions…

Machine Learning · Computer Science 2025-09-03 Huixiang Zhang , Mahzabeen Emu , Salimur Choudhury

The Quadratic Unconstrained Binary Optimization (QUBO) problems are NP hard; thus, so far, there are no algorithms to solve them efficiently. There are exact methods like the Branch-and-Bound algorithm for smaller problems, and for larger…

Quantum Physics · Physics 2021-06-08 Máté Tibor Veszeli , Gábor Vattay

The Operational Fixed Interval Scheduling Problem aims to find an assignment of jobs to machines that maximizes the total weight of the completed jobs. We introduce a new variant of the problem where we consider the additional goal of…

Emerging Technologies · Computer Science 2023-10-24 Ludmila Botelho , Özlem Salehi

An earlier work [18] proposes a method for solving the Lagrangian dual of a constrained binary quadratic programming problem via quantum adiabatic evolution using an outer approximation method. This should be an efficient prescription for…

Optimization and Control · Mathematics 2019-01-07 Sahar Karimi , Pooya Ronagh

Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the…

Quantum Physics · Physics 2024-05-17 Qi-Ming Ding , Yi-Ming Huang , Xiao Yuan