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The heart beats due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart's electrical system.…

Pattern Formation and Solitons · Physics 2024-04-26 E. Angelaki , N. Lazarides , G. D. Barmparis , I. Kourakis , M. E. Marketou , G. P. Tsironis

The spatial composition and cellular heterogeneity of the tumor microenvironment plays a critical role in cancer development and progression. High-definition pathology imaging of tumor biopsies provide a high-resolution view of the spatial…

Applications · Statistics 2024-06-25 Nathaniel Osher , Jian Kang , Arvind Rao , Veerabhadran Baladandayuthapani

In this paper, we study hybrid neural representations for spherical data, a domain of increasing relevance in scientific research. In particular, our work focuses on weather and climate data as well as comic microwave background (CMB) data.…

Machine Learning · Computer Science 2024-02-12 Hyomin Kim , Yunhui Jang , Jaeho Lee , Sungsoo Ahn

We introduce a novel Bayesian approach for both covariate selection and sparse precision matrix estimation in the context of high-dimensional Gaussian graphical models involving multiple responses. Our approach provides a sparse estimation…

Methodology · Statistics 2024-09-25 Anwesha Chakravarti , Naveen N. Narishetty , Feng Liang

Traffic models based on cellular automata have high computational efficiency because of their simplicity in describing unrealistic vehicular behavior and the versatility of cellular automata to be implemented on parallel processing. On the…

Multiagent Systems · Computer Science 2013-02-05 Emanuele Rodaro , Öznur Yeldan

Solving time-harmonic wave propagation problems in the frequency domain and within heterogeneous media brings many mathematical and computational challenges, especially in the high frequency regime. We will focus here on computational…

Numerical Analysis · Mathematics 2021-09-01 Niall Bootland , Victorita Dolean , Pierre Jolivet , Pierre-Henri Tournier

In this paper, mathematical models for cuff-tissue-artery system are developed and simplified into an axisymmetric problem in space. It is nonlinear properties of cuff and artery wall that make it difficult to solve elastic equations…

Computational Physics · Physics 2020-07-14 Jiacheng Xu , Dan Hu

Learning faithful graph representations as sets of vertex embeddings has become a fundamental intermediary step in a wide range of machine learning applications. The quality of the embeddings is usually determined by how well the geometry…

Machine Learning · Computer Science 2021-05-13 Federico López , Beatrice Pozzetti , Steve Trettel , Anna Wienhard

Fully automatic cardiac segmentation can be a fast and reproducible method to extract clinical measurements from an echocardiography examination. The U-Net architecture is the current state-of-the-art deep learning architecture for medical…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Gilles Van De Vyver , Sarina Thomas , Guy Ben-Yosef , Sindre Hellum Olaisen , Håvard Dalen , Lasse Løvstakken , Erik Smistad

The heterogeneous micromechanical properties of biological tissues have profound implications across diverse medical and engineering domains. However, identifying full-field heterogeneous elastic properties of soft materials using…

Numerical Analysis · Mathematics 2025-07-09 Wensi Wu , Mitchell Daneker , Kevin T. Turner , Matthew A. Jolley , Lu Lu

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang

Mechanical strain and stress play a major role in biological processes such as wound healing or morphogenesis. To assess this role quantitatively, fixed or live images of tissues are acquired at a cellular precision in large fields of…

Tissues and Organs · Quantitative Biology 2019-06-12 M. Durande , S. Tlili , T. Homan , B. Guirao , F. Graner , H. Delanoë-Ayari

Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the…

Medical Physics · Physics 2023-07-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

Elastic network models, simple structure-based representations of biomolecules where atoms interact via short-range harmonic potentials, provide great insight into a molecule's internal dynamics and mechanical properties at extremely low…

Soft Condensed Matter · Physics 2018-12-12 Patrick Diggins , Changjiang Liu , Markus Deserno , Raffaello Potestio

We implement and analyse a sparse / indirect-addressing data structure for the Lattice Boltzmann Method to support efficient compute kernels for fluid dynamics problems with a high number of non-fluid nodes in the domain, such as in porous…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-08-14 Philipp Suffa , Markus Holzer , Harald Köstler , Ulrich Rüde

Accurate analysis of cardiac motion is crucial for evaluating cardiac function. While dynamic cardiac magnetic resonance imaging (CMR) can capture detailed tissue motion throughout the cardiac cycle, the fine-grained 4D cardiac motion…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Xueming Fu , Pei Wu , Yingtai Li , Xin Luo , Zihang Jiang , Junhao Mei , Jian Lu , Gao-Jun Teng , S. Kevin Zhou

Understanding the activity of large populations of neurons is difficult due to the combinatorial complexity of possible cell-cell interactions. To reduce the complexity, coarse-graining had been previously applied to experimental neural…

Neurons and Cognition · Quantitative Biology 2021-03-24 Mia C. Morrell , Audrey J. Sederberg , Ilya Nemenman

Existing permanental processes often impose constraints on kernel types or stationarity, limiting the model's expressiveness. To overcome these limitations, we propose a novel approach utilizing the sparse spectral representation of…

Machine Learning · Statistics 2024-12-20 Zicheng Sun , Yixuan Zhang , Zenan Ling , Xuhui Fan , Feng Zhou

Electroanatomic mapping as routinely acquired in ablation therapy of ventricular tachycardia is the gold standard method to identify the arrhythmogenic substrate. To reduce the acquisition time and still provide maps with high spatial…

Finding accurate reduced descriptions for large, complex, dynamically evolving networks is a crucial enabler to their simulation, analysis, and, ultimately, design. Here we propose and illustrate a systematic and powerful approach to…

Chaotic Dynamics · Physics 2017-05-02 Tom Bertalan , Yan Wu , Carlo Laing , C. William Gear , Ioannis G. Kevrekidis