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Neural interfaces using biocompatible scaffolds provide crucial properties for the functional repair of nerve injuries and neurodegenerative diseases, including cell adhesion, structural support, and mass transport. Neural stimulation has…

Neurons and Cognition · Quantitative Biology 2021-06-29 Nan Zheng , Vincent Fitzpatrick , Ran Cheng , Linli Shi , David L. Kaplan , Chen Yang

Intimate integration of memory devices with logic transistors is a frontier challenge in computer hardware. This integration is essential for augmenting computational power concurrently with enhanced energy efficiency in big-data…

We demonstrate the first hardware implementation of an oscillatory neural network (ONN) utilizing resistive memory (ReRAM) for coupling elements. A ReRAM crossbar array chip, integrated into the Back End of Line (BEOL) of CMOS technology,…

Clinical trials previously demonstrated the notable capacity to elicit visual percepts in blind patients affected with retinal diseases by electrically stimulating the remaining neurons on the retina. However, these implants restored very…

Non-invasive stimulation of small, variably shaped brain sub-regions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two significant trade-offs when targeting brain sub-regions:…

Neurons and Cognition · Quantitative Biology 2025-07-09 Yueming Li , Guo Chen , Tiago R. Oliveira , Nick Todd , Yong-Zhi Zhang , Carolyn Marar , Nan Zheng , Lu Lan , Nathan McDannold , Ji-Xin Cheng , Chen Yang

This work reports back-end-of-line (BEOL) compatible, thin-film transistors (TFTs) with sub-10 nm tungsten-doped tin oxide (TWO) channels deposited by atomic layer deposition (ALD) at 150 $^\circ$C. TFTs with undoped SnO$_{\mathrm{x}}$,…

A Ferroelectric Analog Non-Volatile Memory based on a WOx electrode and ferroelectric HfZrO$_4$ layer is fabricated at a low thermal budget (~375$^\circ$C), enabling BEOL processes and CMOS integration. The devices show suitable properties…

Closed-loop brain stimulation refers to capturing neurophysiological measures such as electroencephalography (EEG), quickly identifying neural events of interest, and producing auditory, magnetic or electrical stimulation so as to interact…

Signal Processing · Electrical Eng. & Systems 2022-10-12 Nicolas Valenchon , Yann Bouteiller , Hugo R. Jourde , Xavier L'Heureux , Milo Sobral , Emily B. J. Coffey , Giovanni Beltrame

Chronic pain affects about 100 million adults in the US. Despite their great need, neuropharmacology and neurostimulation therapies for chronic pain have been associated with suboptimal efficacy and limited long-term success, as their…

Neurons and Cognition · Quantitative Biology 2024-05-03 Pierre Sacré , Sridevi V. Sarma , Yun Guan , William S. Anderson

Nerve stimulation via micro-electrode implants is one of the neurostimulation approaches which is used frequently in the medical treatment of some brain disorders, neural prosthetics, brain-machine interfaces and also in the cyborg. In this…

Biological Physics · Physics 2019-04-30 Yousef Jamali , Mohammad Jamali , Mehdi Golshani

Recent advances in memory technologies, devices and materials have shown great potential for integration into neuromorphic electronic systems. However, a significant gap remains between the development of these materials and the realization…

The growth in data generation necessitates efficient data processing technologies to address the von Neumann bottleneck in conventional computer architecture. Memory-driven computing, which integrates non-volatile memory (NVM) devices in a…

Deep Brain Stimulation (DBS) is an established and powerful treatment method in various neurological disorders. It involves chronically delivering electrical pulses to a certain stimulation target in the brain in order to alleviate the…

Systems and Control · Electrical Eng. & Systems 2023-10-03 Anna Franziska Frigge , Alexander Medvedev , Elena Jiltsova , Dag Nyholm

Computational hardware designed to mimic biological neural networks holds the promise to resolve the drastically growing global energy demand of artificial intelligence. A wide variety of hardware concepts have been proposed, and among…

We introduce a novel electro-optomechanic neural sensor for realizing ultra-compact neural recording probes that can detect and relay electrophysiology signals from within neural tissue. This technology addresses outstanding challenges…

As integrated circuits continue to scale down and adopt three-dimensional (3D) stacking, thermal management in the back-end-of-line (BEOL) has emerged as a critical design constraint. In this study, we present a combined experimental and…

Mesoscale and Nanoscale Physics · Physics 2025-08-12 Yang Shen , Shangzhi Song , Tao Chen , Kexin Zhang , Yu Chen , Lu Zhao , Puqing Jiang

Closed-loop neural interfaces with on-chip machine learning can detect and suppress disease symptoms in neurological disorders or restore lost functions in paralyzed patients. While high-density neural recording can provide rich neural…

Signal Processing · Electrical Eng. & Systems 2023-03-21 Uisub Shin , Cong Ding , Bingzhao Zhu , Yashwanth Vyza , Alix Trouillet , Emilie C. M. Revol , Stéphanie P. Lacour , Mahsa Shoaran

Individuals with severe physical disabilities often experience diminished quality of life stemming from limited ability to engage with their surroundings. Brain-Computer Interface (BCI) technology aims to bridge this gap by enabling direct…

Signal Processing · Electrical Eng. & Systems 2025-06-05 Timothy B Mahoney , JingYang Liu , Huakun Xin , David B Grayden , Sam E John

The advent of dedicated Deep Learning (DL) accelerators and neuromorphic processors has brought on new opportunities for applying both Deep and Spiking Neural Network (SNN) algorithms to healthcare and biomedical applications at the edge.…

Inspired by the dendritic integration and spiking operation of a biological neuron, flexible oxide-based neuron transistors gated by solid-state electrolyte films are fabricated on flexible plastic substrates for biochemical sensing…

Materials Science · Physics 2015-05-20 Ning Liu , Li Qiang Zhu , Ping Feng , Chang Jin Wan , Yang Hui Liu , Yi Shi , Qing Wan
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