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Precision oncology requires accurate molecular insights, yet obtaining these directly from genomics is costly and time-consuming for broad clinical use. Predicting complex molecular features and patient prognosis directly from routine…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Cheng Jin , Fengtao Zhou , Yunfang Yu , Jiabo Ma , Yihui Wang , Yingxue Xu , Huajun Zhou , Hao Jiang , Luyang Luo , Luhui Mao , Zifan He , Xiuming Zhang , Jing Zhang , Ronald Chan , Herui Yao , Hao Chen

Pathology image analysis plays a pivotal role in medical diagnosis, with deep learning techniques significantly advancing diagnostic accuracy and research. While numerous studies have been conducted to address specific pathological tasks,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Dankai Liao , Sicheng Chen , Nuwa Xi , Qiaochu Xue , Jieyu Li , Lingxuan Hou , Zeyu Liu , Chang Han Low , Yufeng Wu , Yiling Liu , Yanqin Jiang , Dandan Li , Shangqing Lyu

Online mapping and end-to-end (E2E) planning in autonomous driving remain largely sensor-centric, leaving rich map priors, including HD/SD vector maps, rasterized SD maps, and satellite imagery, underused because of heterogeneity, pose…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Zongzheng Zhang , Sizhe Zou , Guantian Zheng , Zhenxin Zhu , Yu Gao , Guoxuan Chi , Shuo Wang , Yuwen Heng , Zhigang Sun , Yiru Wang , Hao Sun , Chao Ma , Zhen Li , Anqing Jiang , Hao Zhao

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Medical image analysis typically includes several tasks such as enhancement, segmentation, and classification. Traditionally, these tasks are implemented using separate deep learning models for separate tasks, which is not efficient because…

Computer Vision and Pattern Recognition · Computer Science 2021-06-09 Ghada Zamzmi , Sivaramakrishnan Rajaraman , Sameer Antani

Discovering genes with similar functions across diverse biomedical contexts poses a significant challenge in gene representation learning due to data heterogeneity. In this study, we resolve this problem by introducing a novel model called…

Machine Learning · Computer Science 2023-10-05 Tianyu Liu , Yuge Wang , Rex Ying , Hongyu Zhao

Histopathology and transcriptomics are fundamental modalities in oncology, encapsulating the morphological and molecular aspects of the disease. Multi-modal self-supervised learning has demonstrated remarkable potential in learning…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Tianyi Wang , Jianan Fan , Dingxin Zhang , Dongnan Liu , Yong Xia , Heng Huang , Weidong Cai

The visual attributes of cells, such as the nuclear morphology and chromatin openness, are critical for histopathology image analysis. By learning cell-level visual representation, we can obtain a rich mix of features that are highly…

Computer Vision and Pattern Recognition · Computer Science 2018-07-10 Bo Hu , Ye Tang , Eric I-Chao Chang , Yubo Fan , Maode Lai , Yan Xu

Pathological image segmentation faces numerous challenges, particularly due to ambiguous semantic boundaries and the high cost of pixel-level annotations. Although recent semi-supervised methods based on consistency regularization (e.g.,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mingxi Fu , Fanglei Fu , Xitong Ling , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

We present MMCORE, a unified framework designed for multimodal image generation and editing. MMCORE leverages a pre-trained Vision-Language Model (VLM) to predict semantic visual embeddings via learnable query tokens, which subsequently…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Zijie Li , Yichun Shi , Jingxiang Sun , Ye Wang , Yixuan Huang , Zhiyao Guo , Xiaochen Lian , Peihao Zhu , Yu Tian , Zhonghua Zhai , Peng Wang

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Integrating the different data modalities of cancer patients can significantly improve the predictive performance of patient survival. However, most existing methods ignore the simultaneous utilization of rich semantic features at different…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Liangrui Pan , Yijun Peng , Yan Li , Yiyi Liang , Liwen Xu , Qingchun Liang , Shaoliang Peng

Models for image representation learning are typically designed for either recognition or generation. Various forms of contrastive learning help models learn to convert images to embeddings that are useful for classification, detection, and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Matthew Gwilliam , Xiao Wang , Xuefeng Hu , Zhenheng Yang

The accurate segmentation of medical images is a crucial step in obtaining reliable morphological statistics. However, training a deep neural network for this task requires a large amount of labeled data to ensure high-accuracy results. To…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Xianjun Han , Qianqian Chen , Zhaoyang Xie , Xuejun Li , Hongyu Yang

Unpaired Multi-Modal Learning (UMML) which leverages unpaired multi-modal data to boost model performance on each individual modality has attracted a lot of research interests in medical image analysis. However, existing UMML methods…

Computer Vision and Pattern Recognition · Computer Science 2025-03-10 Lei Zhu , Yanyu Xu , Huazhu Fu , Xinxing Xu , Rick Siow Mong Goh , Yong Liu

Recent developments in spatial omics technologies have enabled the generation of high dimensional molecular data, such as transcriptomes, proteomes, and epigenomes, within their spatial tissue context, either through coprofiling on the same…

Quantitative Methods · Quantitative Biology 2026-01-21 Esra Busra Isik , Yusuf Hakan Usta , Haozhe Liu , Maryam Riazi , William Roach , Hongpeng Zhou , Magnus Rattray , Sokratia Georgaka

Proteins are inherently multiscale physical systems whose functional properties emerge from coordinated structural organization across multiple spatial resolutions, ranging from atomic interactions to global fold topology. However, existing…

Machine Learning · Computer Science 2026-05-13 Viet Thanh Duy Nguyen , John K. Johnstone , Truong-Son Hy

Recent studies have highlighted the interplay between diffusion models and representation learning. Intermediate representations from diffusion models can be leveraged for downstream visual tasks, while self-supervised vision models can…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Xiangxiang Chu , Renda Li , Yong Wang

Image feature matching, a foundational task in computer vision, remains challenging for multimodal image applications, often necessitating intricate training on specific datasets. In this paper, we introduce a Unified Feature Matching…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Yide Di , Yun Liao , Hao Zhou , Kaijun Zhu , Qing Duan , Junhui Liu , Mingyu Lu

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Eric Zimmermann , Julian Viret , Michal Zelechowski , James Brian Hall , Neil Tenenholtz , Adam Casson , George Shaikovski , Eugene Vorontsov , Siqi Liu , Kristen A Severson