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This study presents a novel methodology for stratifying post-myocardial infarction patients at risk of ventricular arrhythmias using patient-specific 3D cardiac models derived from late gadolinium enhancement cardiovascular magnetic…

Computational Engineering, Finance, and Science · Computer Science 2024-09-11 Dolors Serra , Pau Romero , Paula Franco , Ignacio Bernat , Miguel Lozano , Ignacio Garcia-Fernandez , David Soto , Antonio Berruezo , Oscar Camara , Rafael Sebastian

Numerical models are increasingly used for non-invasive diagnosis and treatment planning in coronary artery disease, where service-based technologies have proven successful in identifying hemodynamically significant and hence potentially…

Medical Physics · Physics 2020-05-01 Jongmin Seo , Casey Fleeter , Andrew M. Kahn , Alison L. Marsden , Daniele E. Schiavazzi

A central problem in biomechanical studies of personalised human left ventricular (LV) modelling is estimating the material properties and biophysical parameters from in-vivo clinical measurements in a time frame suitable for use within a…

Applications · Statistics 2019-05-16 Vinny Davies , Umberto Noè , Alan Lazarus , Hao Gao , Benn Macdonald , Colin Berry , Xiaoyu Luo , Dirk Husmeier

The influence and validity of wall boundary conditions for non-equilibrium fluid flows described by the Boltzmann equation remains an open problem. The substantial computational cost of directly solving the Boltzmann equation has limited…

Fluid Dynamics · Physics 2024-01-02 Tarik Dzanic , Freddie D. Witherden , Luigi Martinelli

Computer simulation of "virtual interventions" may inform optimal valve repair for a given patient prior to intervention. However, the paucity of noninvasive methods to determine in vivo mechanical parameters of valves limits the accuracy…

Quantitative Methods · Quantitative Biology 2025-07-09 Wensi Wu , Mitchell Daneker , Christian Herz , Hannah Dewey , Jeffrey A. Weiss , Alison M. Pouch , Lu Lu , Matthew A. Jolley

We report computational results of blood flow through a model of the human aortic arch and a vessel of actual diameter and length. On the top of the aortic arch the branching of the %%three arteries are included: the subclavian and jugular.…

Fluid Dynamics · Physics 2008-11-11 Renat A. Sultanov , Dennis Guster

Stochastic parameterizations are increasingly being used to represent the uncertainty associated with model errors in ensemble forecasting and data assimilation. One of the challenges associated with the use of these parameterizations is…

Computation · Statistics 2019-10-23 Guillermo Scheffler , Juan Ruiz , Manuel Pulido

Inhomogeneities in the aortic wall can lead to localized stress accumulations, possibly initiating dissection. In many cases, a dissection results from pathological changes such as fragmentation or loss of elastic fibers. But it has been…

In applications such as free-space optical communication, a signal is often recovered after propagation through a turbulent medium. In this setting, it is common to assume that limited information is known about the turbulent medium, such…

Optics · Physics 2025-10-13 Anjali Nair , Qin Li , Samuel N. Stechmann

We present a novel framework for assimilating planar PIV experimental data using a variational approach to enhance the predictions of the Spalart-Allmaras RANS turbulence model. Our method applies three-dimensional constraints to the…

Fluid Dynamics · Physics 2026-01-27 Uttam Cadambi Padmanaban , Bharathram Ganapathisubramani , Sean Symon

We introduce a continuous data assimilation (downscaling) algorithm for the two-dimensional Navier-Stokes equations employing coarse mesh measurements of only one component of the velocity field. This algorithm can be implemented with a…

Analysis of PDEs · Mathematics 2016-03-23 Aseel Farhat , Evelyn Lunasin , Edriss S. Titi

The URANS equations provide a computationally efficient tool to simulate unsteady turbulent flows for a wide range of applications. To account for the errors introduced by the turbulence closure model, recent works have adopted data…

Fluid Dynamics · Physics 2025-01-22 Justin Plogmann , Oliver Brenner , Patrick Jenny

The statistics obtained from turbulent flow simulations are generally uncertain due to finite time averaging. The techniques available in the literature to accurately estimate these uncertainties typically only work in an offline mode, that…

A stochastic Machine-Learning approach is developed for data-driven Reynolds-Averaged Navier-Stokes (RANS) predictions of turbulent flows, with quantified model uncertainty. This is done by combining a Bayesian symbolic identification…

Fluid Dynamics · Physics 2025-02-05 Soufiane Cherroud , Xavier Merle , Paola Cinnella , Xavier Gloerfelt

We extend flow matching to ensembles of linear systems in both deterministic and stochastic settings. Averaging over system parameters induces memory leading to a non-Markovian interpolation problem for the stochastic case. In this setting,…

Optimization and Control · Mathematics 2025-10-17 Daniel Owusu Adu , Yongxin Chen

Engineering simulations using boundary-value partial differential equations often implicitly assume that the uncertainty in the location of the boundary has a negligible impact on the output of the simulation. In this work, we develop a…

Tissues and Organs · Quantitative Biology 2024-06-11 S. Gerry Gralton , Farah Alkhatib , Ben Zwick , George Bourantas , Adam Wittek , Karol Miller

We consider a parameter estimation problem to determine the viscosity $\nu$ of a stochastically perturbed 2D Navier-Stokes system. We derive several different classes of estimators based on the first $N$ Fourier modes of a single sample…

Probability · Mathematics 2011-01-07 Igor Cialenco , Nathan Glatt-Holtz

The choice of appropriate boundary conditions is a crucial step in the development of cardiovascular models for blood flow simulations. The three-element Windkessel model is usually employed as a lumped boundary condition, providing a…

Medical Physics · Physics 2022-08-25 Elisa Fevola , Tommaso Bradde , Piero Triverio , Stefano Grivet-Talocia

Continuum fluid dynamic models based on the Navier-Stokes equations have previously been used to simulate granular media undergoing fluid-like shearing. These models, however, typically fail to predict the flow behaviour in confined…

Fluid Dynamics · Physics 2024-03-05 Duncan Dockar , M. H. Lakshminarayana Reddy , Matthew K. Borg , S. Kokou Dadzie

In fluid physics, data-driven models to enhance or accelerate solution methods are becoming increasingly popular for many application domains, such as alternatives to turbulence closures, system surrogates, or for new physics discovery. In…