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Multiple instance learning (MIL) has become the leading approach for extracting discriminative features from whole slide images (WSIs) in computational pathology. Attention-based MIL methods can identify key patches but tend to overlook…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Lubin Gan , Xiaoman Wu , Jing Zhang , Zhifeng Wang , Linhao Qu , Siying Wu , Xiaoyan Sun

Speech Emotion Recognition (SER) in real-world scenarios remains challenging due to severe class imbalance and the prevalence of spontaneous, natural speech. While recent approaches leverage self-supervised learning (SSL) representations…

Audio and Speech Processing · Electrical Eng. & Systems 2026-03-26 Lucas H. Ueda , João G. T. Lima , Paula D. P. Costa

Advances in computational pathology increasingly rely on extracting meaningful representations from Whole Slide Images (WSIs) to support various clinical and biological tasks. In this study, we propose a generalizable deep learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shakib Khan , Fariba Dambandkhameneh , Nazim Shaikh , Yao Nie , Raghavan Venugopal , Xiao Li

In computational cytology, detecting malignancy on whole-slide images is difficult because malignant cells are morphologically diverse yet vanishingly rare amid a vast background of normal cells. Accurate detection of these extremely rare…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Swarnadip Chatterjee , Vladimir Basic , Arrigo Capitanio , Orcun Goksel , Joakim Lindblad

Whole-slide image analysis via the means of computational pathology often relies on processing tessellated gigapixel images with only slide-level labels available. Applying multiple instance learning-based methods or transformer models is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Joshua Butke , Noriaki Hashimoto , Ichiro Takeuchi , Hiroaki Miyoshi , Koichi Ohshima , Jun Sakuma

The field of computer vision is undergoing a paradigm shift toward large-scale foundation model pre-training via self-supervised learning (SSL). Leveraging large volumes of unlabeled brain MRI data, such models can learn anatomical priors…

Image and Video Processing · Electrical Eng. & Systems 2026-01-15 Petros Koutsouvelis , Matej Gazda , Leroy Volmer , Sina Amirrajab , Kamil Barbierik , Branislav Setlak , Jakub Gazda , Peter Drotar

Self-supervised learning can be used for mitigating the greedy needs of Vision Transformer networks for very large fully-annotated datasets. Different classes of self-supervised learning offer representations with either good contextual…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Spyros Gidaris , Andrei Bursuc , Oriane Simeoni , Antonin Vobecky , Nikos Komodakis , Matthieu Cord , Patrick Pérez

Learning representations for individual instances when only bag-level labels are available is a fundamental challenge in multiple instance learning (MIL). Recent works have shown promising results using contrastive self-supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Kangning Liu , Weicheng Zhu , Yiqiu Shen , Sheng Liu , Narges Razavian , Krzysztof J. Geras , Carlos Fernandez-Granda

Computational pathology involves the digitization of stained tissues into whole-slide images (WSIs) that contain billions of pixels arranged as contiguous patches. Statistical analysis of WSIs largely focuses on classification via multiple…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 So Won Jeong , Veronika Ročková

Image-based cell profiling aims to create informative representations of cell images. This technique is critical in drug discovery and has greatly advanced with recent improvements in computer vision. Inspired by recent developments in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Siran Dai , Qianqian Xu , Peisong Wen , Yang Liu , Qingming Huang

Cancer subtyping is one of the most challenging tasks in digital pathology, where Multiple Instance Learning (MIL) by processing gigapixel whole slide images (WSIs) has been in the spotlight of recent research. However, MIL approaches do…

Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…

Predicting the response of a patient to a cancer treatment is of high interest. Nonetheless, this task is still challenging from a medical point of view due to the complexity of the interaction between the patient organism and the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-09 Bilel Guetarni , Feryal Windal , Halim Benhabiles , Mahfoud Chaibi , Romain Dubois , Emmanuelle Leteurtre , Dominique Collard

Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumour regions and reflecting intrinsic morphological heterogeneity. However, most existing approaches rely on a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Zahra Rahimi Afzal , Wataru Uegami , Saghir Alfasly , Saba Yasir , Judy C. Boughey , Matthew P. Goetz , Krishna R. Kalari , H. R. Tizhoosh

Self-supervised learning (SSL) has demonstrated its effectiveness in learning representations through comparison methods that align with human intuition. However, mainstream SSL methods heavily rely on high body datasets with single label,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Jiale Chen

Self-supervised learning algorithms (SSL) based on instance discrimination have shown promising results, performing competitively or even outperforming supervised learning counterparts in some downstream tasks. Such approaches employ data…

Computer Vision and Pattern Recognition · Computer Science 2025-05-01 Mohammad Alkhalefi , Georgios Leontidis , Mingjun Zhong

Multimodal evidence is critical in computational pathology: gigapixel whole slide images capture tumor morphology, while patient-level clinical descriptors preserve complementary context for prognosis. Integrating such heterogeneous signals…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Chengying She , Chengwei Chen , Xinran Zhang , Ben Wang , Lizhuang Liu , Chengwei Shao , Yun Bian

Whole Slide Imaging (WSI) has become a gold standard in cancer diagnosis, inspecting multi-scale information from cellular to tissue levels. Processing an entire WSI directly is infeasible due to GPU memory constraints; thus, Multiple…

Image and Video Processing · Electrical Eng. & Systems 2026-05-08 Tianyi Zhang , Sicheng Chen , Borui Kang , Dankai Liao , Qiaochu Xue , Bochong Zhang , Fei Xia , Zeyu Liu , Yueming Jin

Multiple instance learning (MIL) has been successfully applied for whole slide images (WSIs) analysis in computational pathology, enabling a wide range of prediction tasks from tumor subtyping to inferring genetic mutations and multi-omics…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Junyu Li , Ye Zhang , Wen Shu , Xiaobing Feng , Yingchun Wang , Pengju Yan , Xiaolin Li , Chulin Sha , Min He

Despite impressive empirical advances of SSL in solving various tasks, the problem of understanding and characterizing SSL representations learned from input data remains relatively under-explored. We provide a comparative analysis of how…

Computer Vision and Pattern Recognition · Computer Science 2023-06-05 Xavier F. Cadet , Ranya Aloufi , Alain Miranville , Sara Ahmadi-Abhari , Hamed Haddadi
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