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Multiple Instance Learning (MIL) and transformers are increasingly popular in histopathology Whole Slide Image (WSI) classification. However, unlike human pathologists who selectively observe specific regions of histopathology tissues under…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Conghao Xiong , Hao Chen , Joseph J. Y. Sung , Irwin King

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Self-Supervised Learning (SSL) is an important paradigm for learning representations from unlabelled data, and SSL with neural networks has been highly successful in practice. However current theoretical analysis of SSL is mostly restricted…

Machine Learning · Computer Science 2023-09-06 Pascal Esser , Satyaki Mukherjee , Debarghya Ghoshdastidar

In modern cancer diagnostics, Whole Slide Imaging (WSI) is widely used to digitize tissue specimens for detailed, high-resolution examination; however, other diagnostic approaches, such as liquid biopsy and molecular testing, are also…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Seyed Kahaki , Alexander R. Webber , Ghada Zamzmi , Adarsh Subbaswamy , Rucha Deshpande , Aldo Badano

Masked Image Modelling (MIM) has been shown to be an efficient self-supervised learning (SSL) pre-training paradigm when paired with transformer architectures and in the presence of a large amount of unlabelled natural images. The…

Computer Vision and Pattern Recognition · Computer Science 2023-01-02 Alvaro Fernandez-Quilez , Christoffer Gabrielsen Andersen , Trygve Eftestøl , Svein Reidar Kjosavik , Ketil Oppedal

Few-shot learning presents a critical solution for cancer diagnosis in computational pathology (CPath), addressing fundamental limitations in data availability, particularly the scarcity of expert annotations and patient privacy…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Zhengrui Guo , Conghao Xiong , Jiabo Ma , Qichen Sun , Lishuang Feng , Jinzhuo Wang , Hao Chen

In histopathology, intelligent diagnosis of Whole Slide Images (WSIs) is essential for automating and objectifying diagnoses, reducing the workload of pathologists. However, diagnostic models often face the challenge of forgetting…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Weixi Zheng , Aoling Huang , Jingping Yuan , Haoyu Zhao , Zhou Zhao , Yongchao Xu , Thierry Géraud

Cancer is a complex disease that provides various types of information depending on the scale of observation. While most tumor diagnostics are performed by observing histopathological slides, radiology images should yield additional…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Marvin Lerousseau , Eric Deutsh , Nikos Paragios

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

Self-supervised learning (SSL) plays a central role in molecular representation learning. Yet, many recent innovations in masking-based pretraining are introduced as heuristics and lack principled evaluation, obscuring which design choices…

Machine Learning · Computer Science 2025-12-09 Jiannan Yang , Veronika Thost , Tengfei Ma

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

In this work, we propose a novel straightforward method for medical volume and sequence segmentation with limited annotations. To avert laborious annotating, the recent success of self-supervised learning(SSL) motivates the pre-training on…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Zejian Chen , Wei Zhuo , Tianfu Wang , Wufeng Xue , Dong Ni

Computational pathology, which involves analyzing whole slide images for automated cancer diagnosis, relies on multiple instance learning, where performance depends heavily on the feature extractor and aggregator. Recent Pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Conghao Xiong , Hao Chen , Joseph J. Y. Sung

Self-supervised learning (SSL) has emerged as a promising paradigm for medical image analysis by harnessing unannotated data. Despite their potential, the existing SSL approaches overlook the high anatomical similarity inherent in medical…

Computer Vision and Pattern Recognition · Computer Science 2024-08-09 Azad Singh , Deepak Mishra

Self-supervised learning (SSL) has emerged as a powerful strategy for representation learning under limited annotation regimes, yet its effectiveness remains highly sensitive to many factors, especially the nature of the target task. In…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Jorge Quesada , Ghassan AlRegib

Self-supervised learning (SSL) has produced a diverse landscape of vision transformers (ViTs) whose pretrained representations support a wide range of downstream tasks. Towards a better understanding of these models, a body of work has…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Xiaoyan Yu , Lisa Mais , Jannik Franzen , Peter Hirsch , Nick Lechtenbörger , Andreas Mardt , Dagmar Kainmüller

Multiple instance learning (MIL) stands as a powerful approach in weakly supervised learning, regularly employed in histological whole slide image (WSI) classification for detecting tumorous lesions. However, existing mainstream MIL methods…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

The fundamental goal of self-supervised learning (SSL) is to produce useful representations of data without access to any labels for classifying the data. Modern methods in SSL, which form representations based on known or constructed…

Machine Learning · Computer Science 2022-09-30 Bobak T. Kiani , Randall Balestriero , Yubei Chen , Seth Lloyd , Yann LeCun

Increased levels of tumor infiltrating lymphocytes (TILs) in cancer tissue indicate favourable outcomes in many types of cancer. Manual quantification of immune cells is inaccurate and time consuming for pathologists. Our aim is to leverage…

In this paper, we introduce a novel self-supervised learning (SSL) loss for image representation learning. There is a growing belief that generalization in deep neural networks is linked to their ability to discriminate object shapes. Since…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Sepehr Sameni , Simon Jenni , Paolo Favaro
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