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Parameter-Efficient Fine-Tuning (PEFT) has risen as an innovative training strategy that updates only a select few model parameters, significantly lowering both computational and memory demands. PEFT also helps to decrease data transfer in…

Compared to Full-Model Fine-Tuning (FMFT), Parameter Efficient Fine-Tuning (PEFT) has demonstrated superior performance and lower computational overhead in several code understanding tasks, such as code summarization and code search. This…

We primarily focus on the field of large language models (LLMs) for recommendation, which has been actively explored recently and poses a significant challenge in effectively enhancing recommender systems with logical reasoning abilities…

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Fine-tuning Large Language Models (LLMs) is a common practice to adapt pre-trained models for specific applications. While methods like LoRA have effectively addressed GPU memory constraints during fine-tuning, their performance often falls…

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Low-Rank Adaptation (LoRA) is a widely-used parameter-efficient finetuning method for large language models. LoRA saves memory by training only low rank perturbations to selected weight matrices. In this work, we compare the performance of…

Finetuned LLMs often exhibit poor uncertainty quantification, manifesting as overconfidence, poor calibration, and unreliable prediction results on test data or out-of-distribution samples. One approach commonly used in vision for…

As advancements in large language models (LLMs) continue and the demand for personalized models increases, parameter-efficient fine-tuning (PEFT) methods (e.g., LoRA) will become essential due to their efficiency in reducing computation…

Low-rank adaptation, also known as LoRA, has emerged as a prominent method for parameter-efficient fine-tuning of foundation models. Despite its computational efficiency, LoRA still yields inferior performance compared to full fine-tuning.…

With the exponential increase of the protein sequence databases over time, multiple-sequence alignment (MSA) methods, like PSI-BLAST, perform exhaustive and time-consuming database search to retrieve evolutionary information. The resulting…

Low-rank adaptation (LoRA) and its variants have recently gained much interest due to their ability to avoid excessive inference costs. However, LoRA still encounters the following challenges: (1) Limitation of low-rank assumption; and (2)…

Large Language Models (LLMs) demonstrate exceptional performance across various tasks but demand substantial computational resources even for fine-tuning computation. Although Low-Rank Adaptation (LoRA) significantly alleviates memory…

The rapid advancements in Large Language Models (LLMs) have revolutionized natural language processing (NLP) and related fields. However, fine-tuning these models for specific tasks remains computationally expensive and risks degrading…

Fine-tuning large language models for domain-specific tasks such as medical text summarization demands substantial computational resources. Parameter-efficient fine-tuning (PEFT) methods offer promising alternatives by updating only a small…

We introduce RosettaSearch, an inference-time multi-objective optimization approach for backbone conditioned protein sequence design. We use large language models (LLMs) as a generative optimizer within a search algorithm capable of…

With the rapid development of Large Language Models (LLMs), Parameter-Efficient Fine-Tuning (PEFT) methods have gained significant attention, which aims to achieve efficient fine-tuning of LLMs with fewer parameters. As a representative…

Protein language models (PLMs) learn probability distributions over natural protein sequences. By learning from hundreds of millions of natural protein sequences, protein understanding and design capabilities emerge. Recent works have shown…

Large Language Models (LLMs), such as LLaMA and T5, have shown exceptional performance across various tasks through fine-tuning. Although low-rank adaption (LoRA) has emerged to cheaply fine-tune these LLMs on downstream tasks, their…

The scaling of Large Language Models (LLMs) for retrieval-based tasks, particularly in Retrieval Augmented Generation (RAG), faces significant memory constraints, especially when fine-tuning extensive prompt sequences. Current open-source…