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Whole slide images (WSIs) in computational pathology (CPath) pose a major computational challenge due to their gigapixel scale, often requiring the processing of tens to hundreds of thousands of high-resolution patches per slide. This…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Yonghan Shin , SeungKyu Kim , Won-Ki Jeong

Computerized Adaptive Testing (CAT) is emerging as a promising testing application in many scenarios, such as education, game and recruitment, which targets at diagnosing the knowledge mastery levels of examinees on required concepts. It…

Artificial Intelligence · Computer Science 2021-01-18 Haoyang Bi , Haiping Ma , Zhenya Huang , Yu Yin , Qi Liu , Enhong Chen , Yu Su , Shijin Wang

Visual foundation models like CLIP excel in learning feature representations from extensive datasets through self-supervised methods, demonstrating remarkable transfer learning and generalization capabilities. A growing number of…

Computer Vision and Pattern Recognition · Computer Science 2023-06-23 Binjie Zhang , Yixiao Ge , Xuyuan Xu , Ying Shan , Mike Zheng Shou

The accelerated adoption of digital pathology and advances in deep learning have enabled the development of powerful models for various pathology tasks across a diverse array of diseases and patient cohorts. However, model training is often…

Pathology is essential for cancer diagnosis, with multiple instance learning (MIL) widely used for whole slide image (WSI) analysis. WSIs exhibit a natural hierarchy -- patches, regions, and slides -- with distinct semantic associations.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Peixiang Huang , Yanyan Huang , Weiqin Zhao , Junjun He , Lequan Yu

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-08 Hao Li , Ying Chen , Yifei Chen , Wenxian Yang , Bowen Ding , Yuchen Han , Liansheng Wang , Rongshan Yu

Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Mingrui Ma , Chentao Li , Pan Huang , Jing Qin

Cancer progression arises from interactions across multiple biological layers, especially beyond morphological and across molecular layers that remain invisible to image-only models. To capture this broader biological landscape, we present…

Machine Learning · Computer Science 2025-12-17 Juseung Yun , Sunwoo Yu , Sumin Ha , Jonghyun Kim , Janghyeon Lee , Jongseong Jang , Soonyoung Lee

Purpose: Recent developments in computational pathology have been driven by advances in Vision Foundation Models, particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Xueyuan Li , Can Cui , Ruining Deng , Yucheng Tang , Quan Liu , Tianyuan Yao , Shunxing Bao , Naweed Chowdhury , Haichun Yang , Yuankai Huo

Vision-language models (VLMs) exhibit remarkable zero-shot generalization but suffer performance degradation under distribution shifts in downstream tasks, particularly in the absence of labeled data. Test-Time Adaptation (TTA) addresses…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Khanh-Binh Nguyen , Phuoc-Nguyen Bui , Hyunseung Choo , Duc Thanh Nguyen

Computational pathology needs whole-slide image (WSI) foundation models that transfer across diverse clinical tasks, yet current approaches remain largely slide-centric, often depend on private data and expensive paired-report supervision,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Yousef Kotp , Vincent Quoc-Huy Trinh , Christopher Pal , Mahdi S. Hosseini

The increasing scale and complexity of modern model parameters underscore the importance of pre-trained models. However, deployment often demands architectures of varying sizes, exposing limitations of conventional pre-training and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Yucheng Xie , Fu Feng , Ruixiao Shi , Jing Wang , Yong Rui , Xin Geng

Whole-slide image (WSI) preprocessing, comprising tissue detection followed by patch extraction, is foundational to AI-driven computational pathology but remains a major bottleneck for scaling to large and heterogeneous cohorts. We present…

Promptable foundation models, particularly Segment Anything Model (SAM), have emerged as a promising alternative to the traditional task-specific supervised learning for image segmentation. However, many evaluation studies have found that…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Rachana Sathish , Rahul Venkataramani , K S Shriram , Prasad Sudhakar

This paper introduces the Pandemic PACT Advanced Categorisation Engine (PPACE) along with its associated dataset. PPACE is a fine-tuned model developed to automatically classify research abstracts from funded biomedical projects according…

CRATE, a white-box transformer architecture designed to learn compressed and sparse representations, offers an intriguing alternative to standard vision transformers (ViTs) due to its inherent mathematical interpretability. Despite…

Computer Vision and Pattern Recognition · Computer Science 2025-01-15 Jinrui Yang , Xianhang Li , Druv Pai , Yuyin Zhou , Yi Ma , Yaodong Yu , Cihang Xie

This paper provides estimation and inference methods for a conditional average treatment effects (CATE) characterized by a high-dimensional parameter in both homogeneous cross-sectional and unit-heterogeneous dynamic panel data settings. In…

Machine Learning · Statistics 2022-12-13 Vira Semenova , Matt Goldman , Victor Chernozhukov , Matt Taddy

The domain shift in pathological segmentation is an important problem, where a network trained by a source domain (collected at a specific hospital) does not work well in the target domain (from different hospitals) due to the different…

Computer Vision and Pattern Recognition · Computer Science 2023-04-27 Xiaoqing Liu , Kengo Araki , Shota Harada , Akihiko Yoshizawa , Kazuhiro Terada , Mariyo Kurata , Naoki Nakajima , Hiroyuki Abe , Tetsuo Ushiku , Ryoma Bise

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo

We consider the problem of task-agnostic feature upsampling in dense prediction where an upsampling operator is required to facilitate both region-sensitive tasks like semantic segmentation and detail-sensitive tasks such as image matting.…

Computer Vision and Pattern Recognition · Computer Science 2022-12-29 Hao Lu , Wenze Liu , Hongtao Fu , Zhiguo Cao