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Document understanding is critical for applications from financial analysis to scientific discovery. Current approaches, whether OCR-based pipelines feeding Large Language Models (LLMs) or native Multimodal LLMs (MLLMs), face key…

Computation and Language · Computer Science 2026-04-21 Sensen Gao , Shanshan Zhao , Xu Jiang , Lunhao Duan , Yong Xien Chng , Qing-Guo Chen , Weihua Luo , Kaifu Zhang , Jia-Wang Bian , Mingming Gong

Despite significant advancements, current large language models (LLMs) and vision-language models (LVLMs) continue to struggle with complex, multi-step, cross-modal common sense reasoning tasks, often exhibiting a lack of "deliberative…

Computation and Language · Computer Science 2025-08-06 Wenjie Luo , Ruocheng Li , Shanshan Zhu , Julian Perry

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

Computation and Language · Computer Science 2025-02-28 Kai Zhang , Rui Zhu , Shutian Ma , Jingwei Xiong , Yejin Kim , Fabricio Murai , Xiaozhong Liu

Large Language Models (LLMs), despite their remarkable capabilities, rely on singular, pre-dominant reasoning paradigms, hindering their performance on intricate problems that demand diverse cognitive strategies. To address this, we…

Computation and Language · Computer Science 2025-09-29 Zishan Ahmad , Saisubramaniam Gopalakrishnan

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Large Language Models (LLMs) encounter challenges with the unique syntax of specific domains, such as biomolecules. Existing fine-tuning or modality alignment techniques struggle to bridge the domain knowledge gap and understand complex…

Biomolecules · Quantitative Biology 2024-06-28 Jinzhe Liu , Xiangsheng Huang , Zhuo Chen , Yin Fang

Medical vision-language models (VLMs) show strong performance on radiology tasks but often produce fluent yet weakly grounded conclusions due to over-reliance on a dominant modality. We introduce a context-aligned reasoning framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Sumra Khan , Sagar Chhabriya , Aizan Zafar , Sheeraz Arif , Amgad Muneer , Anas Zafar , Shaina Raza , Rizwan Qureshi

As large language models (LLMs) become increasingly integrated into clinical decision-making, ensuring transparent and trustworthy reasoning is essential. However, existing evaluation strategies of LLMs' medical reasoning capability either…

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

The integration of external knowledge through Retrieval-Augmented Generation (RAG) has become foundational in enhancing large language models (LLMs) for knowledge-intensive tasks. However, existing RAG paradigms often overlook the cognitive…

Artificial Intelligence · Computer Science 2025-09-24 Yu Wang , Shiwan Zhao , Zhihu Wang , Ming Fan , Xicheng Zhang , Yubo Zhang , Zhengfan Wang , Heyuan Huang , Ting Liu

While large audio-language models (LALMs) have demonstrated state-of-the-art audio understanding, their reasoning capability in complex soundscapes still falls behind large vision-language models (LVLMs). Compared to the visual domain, one…

Sound · Computer Science 2025-09-22 Qiaolin Wang , Xilin Jiang , Linyang He , Junkai Wu , Nima Mesgarani

Patient-trial matching requires reasoning over long, heterogeneous electronic health records (EHRs) and complex eligibility criteria, posing significant challenges for scalability, generalization, and computational efficiency. Existing…

Computation and Language · Computer Science 2026-04-27 Xiaodi Li , Yang Xiao , Munhwan Lee , Konstantinos Leventakos , Young J. Juhn , David Jones , Terence T. Sio , Wei Liu , Maria Vassilaki , Nansu Zong

Owing to their powerful semantic reasoning capabilities, Large Language Models (LLMs) have been effectively utilized as recommenders, achieving impressive performance. However, the high inference latency of LLMs significantly restricts…

Information Retrieval · Computer Science 2024-08-21 Yu Cui , Feng Liu , Pengbo Wang , Bohao Wang , Heng Tang , Yi Wan , Jun Wang , Jiawei Chen

The application of Artificial Intelligence (AI) in healthcare has been revolutionary, especially with the recent advancements in transformer-based Large Language Models (LLMs). However, the task of understanding unstructured electronic…

Computation and Language · Computer Science 2023-08-08 Shivani Shekhar , Simran Tiwari , T. C. Rensink , Ramy Eskander , Wael Salloum

The increasing demand for intelligent systems capable of interpreting and reasoning about visual content requires the development of large Vision-and-Language Models (VLMs) that are not only accurate but also have explicit reasoning…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Kohei Uehara , Nabarun Goswami , Hanqin Wang , Toshiaki Baba , Kohtaro Tanaka , Tomohiro Hashimoto , Kai Wang , Rei Ito , Takagi Naoya , Ryo Umagami , Yingyi Wen , Tanachai Anakewat , Tatsuya Harada

Large language models (LLMs) are increasingly recognized as valuable tools across the medical environment, supporting clinical, research, and administrative workflows. However, strict privacy and network security regulations in hospital…

Computation and Language · Computer Science 2026-01-09 Seokhwan Ko , Donghyeon Lee , Jaewoo Chun , Hyungsoo Han , Junghwan Cho

Knowledge distillation typically involves transferring knowledge from a Large Language Model (LLM) to a Smaller Language Model (SLM). However, in tasks such as text matching, fine-tuned smaller models often yield more effective…

Computation and Language · Computer Science 2025-07-09 Mingzhe Li , Jing Xiang , Qishen Zhang , Kaiyang Wan , Xiuying Chen

Multimodal reasoning with large language models (LLMs) often suffers from hallucinations and the presence of deficient or outdated knowledge within LLMs. Some approaches have sought to mitigate these issues by employing textual knowledge…

Computation and Language · Computer Science 2024-06-06 Junlin Lee , Yequan Wang , Jing Li , Min Zhang

Medical question answering (QA) requires extensive access to domain-specific knowledge. A promising direction is to enhance large language models (LLMs) with external knowledge retrieved from medical corpora or parametric knowledge stored…

Computation and Language · Computer Science 2025-10-22 Lei Li , Xiao Zhou , Yingying Zhang , Xian Wu

Medical image classifiers detect gastrointestinal diseases well, but they do not explain their decisions. Large language models can generate clinical text, yet they struggle with visual reasoning and often produce unstable or incorrect…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Md. Najib Hasan , Imran Ahmad , Sourav Basak Shuvo , Md. Mahadi Hasan Ankon , Sunanda Das , Nazmul Siddique , Hui Wang