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Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Cognitive Diagnosis Models (CDMs) are designed to assess students' cognitive states by analyzing their performance across a series of exercises. However, existing CDMs often struggle with diagnosing infrequent students and exercises due to…

Artificial Intelligence · Computer Science 2025-02-11 Zhiang Dong , Jingyuan Chen , Fei Wu

Medical tasks such as diagnosis and treatment planning require precise and complex reasoning, particularly in life-critical domains. Unlike mathematical reasoning, medical reasoning demands meticulous, verifiable thought processes to ensure…

Computation and Language · Computer Science 2025-04-08 Juncheng Wu , Wenlong Deng , Xingxuan Li , Sheng Liu , Taomian Mi , Yifan Peng , Ziyang Xu , Yi Liu , Hyunjin Cho , Chang-In Choi , Yihan Cao , Hui Ren , Xiang Li , Xiaoxiao Li , Yuyin Zhou

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Computation and Language · Computer Science 2025-07-11 Sabine Felde , Rüdiger Buchkremer , Gamal Chehab , Christian Thielscher , Jörg HW Distler , Matthias Schneider , Jutta G. Richter

Inductive reasoning is an essential capability for large language models (LLMs) to achieve higher intelligence, which requires the model to generalize rules from observed facts and then apply them to unseen examples. We present MIRAGE, a…

Computation and Language · Computer Science 2025-03-03 Jiachun Li , Pengfei Cao , Zhuoran Jin , Yubo Chen , Kang Liu , Jun Zhao

Existing medical RAG systems mainly leverage knowledge from medical knowledge bases, neglecting the crucial role of experiential knowledge derived from similar patient cases -- a key component of human clinical reasoning. To bridge this…

Computation and Language · Computer Science 2025-05-27 Yuxing Lu , Gecheng Fu , Wei Wu , Xukai Zhao , Sin Yee Goi , Jinzhuo Wang

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…

Explainable disease diagnosis, which leverages patient information (e.g., signs and symptoms) and computational models to generate probable diagnoses and reasonings, offers clear clinical values. However, when clinical notes encompass…

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Large Language Models (LLMs) have demonstrated remarkable performance across a wide range of natural language processing tasks. However, their enormous parameter size and extremely high requirements for compute power pose challenges for…

Computation and Language · Computer Science 2024-03-26 Bohao Yang , Chen Tang , Kun Zhao , Chenghao Xiao , Chenghua Lin

Standard classification models often map inputs directly to labels without explicit reasoning, potentially limiting their performance, robustness, and interpretability. This paper introduces a novel two-stage approach to enhance text…

Computation and Language · Computer Science 2025-07-02 Mads Henrichsen , Rasmus Krebs

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Retrieval-augmented generation (RAG) enables large language models (LLMs) to dynamically access external information, which is powerful for answering questions over previously unseen documents. Nonetheless, they struggle with high-level…

Artificial Intelligence · Computer Science 2026-04-21 Chi-Hsiang Hsiao , Yi-Cheng Wang , Tzung-Sheng Lin , Yi-Ren Yeh , Chu-Song Chen

While Retrieval-Augmented Generation (RAG) plays a crucial role in the application of Large Language Models (LLMs), existing retrieval methods in knowledge-dense domains like law and medicine still suffer from a lack of multi-perspective…

Computation and Language · Computer Science 2025-10-24 Guanhua Chen , Wenhan Yu , Xiao Lu , Xiao Zhang , Erli Meng , Lei Sha

Recently, Large Language Models (LLMs) have been increasingly used to support various decision-making tasks, assisting humans in making informed decisions. However, when LLMs confidently provide incorrect information, it can lead humans to…

Information Retrieval · Computer Science 2025-10-16 Chaeyun Jang , Deukhwan Cho , Seanie Lee , Hyungi Lee , Juho Lee

Multimodal document question answering requires retrieving dispersed evidence from visually rich long documents and performing reliable reasoning over heterogeneous information. Existing multimodal RAG systems remain limited by two…

Information Retrieval · Computer Science 2026-03-18 Jiashu Yang , Chi Zhang , Abudukelimu Wuerkaixi , Xuxin Cheng , Cao Liu , Ke Zeng , Xu Jia , Xunliang Cai

Large Language Models (LLMs) have achieved strong performance across a wide range of natural language processing tasks in recent years, including machine translation, text generation, and question answering. As their applications extend to…

Computation and Language · Computer Science 2025-12-30 Xin Zhang , Yang Cao , Baoxing Wu , Xinyi Chen , Kai Song , Siying Li

Large language models (LLMs) are proficient at generating fluent text with minimal task-specific supervision. Yet, their ability to provide well-grounded rationalizations for knowledge-intensive tasks remains under-explored. Such tasks,…

Computation and Language · Computer Science 2024-02-02 Aditi Mishra , Sajjadur Rahman , Hannah Kim , Kushan Mitra , Estevam Hruschka

The adoption of large language models (LLMs) in healthcare has attracted significant research interest. However, their performance in healthcare remains under-investigated and potentially limited, due to i) they lack rich domain-specific…

Artificial Intelligence · Computer Science 2024-05-21 Zishan Gu , Fenglin Liu , Changchang Yin , Ping Zhang

Integrating large language models (LLMs) like DeepSeek R1 into healthcare requires rigorous evaluation of their reasoning alignment with clinical expertise. This study assesses DeepSeek R1's medical reasoning against expert patterns using…

Computation and Language · Computer Science 2025-04-02 Birger Moell , Fredrik Sand Aronsson , Sanian Akbar
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