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Retrieval-augmented generation combined with reinforcement learning has shown promise for grounding large language models in trustworthy medical evidence. However, existing methods rely on exact-match binary rewards, which in clinical…

Artificial Intelligence · Computer Science 2026-05-28 Yuwei Miao , Gen Li , Yunsheng Zeng , Xiandong Li , Yujin Wang , Siyu Chen , Luning Wang , Yunhao Qiao , Junfeng Wang , Jianwei Lv , Bo Yuan

Improving performance on complex tasks and enabling interpretable decision making in large language models (LLMs), especially for clinical applications, requires effective reasoning. Yet this remains challenging without supervised…

Computation and Language · Computer Science 2025-05-26 Che Liu , Haozhe Wang , Jiazhen Pan , Zhongwei Wan , Yong Dai , Fangzhen Lin , Wenjia Bai , Daniel Rueckert , Rossella Arcucci

Large Language Models (LLMs) have shown promising performance on diverse medical benchmarks, highlighting their potential in supporting real-world clinical tasks. Retrieval-Augmented Generation (RAG) has emerged as a key approach for…

Computation and Language · Computer Science 2025-09-30 Kaishuai Xu , Wenjun Hou , Yi Cheng , Wenjie Li

While large language models (LLMs) have demonstrated impressive capabilities across various natural language processing tasks by acquiring rich factual knowledge from their broad training data, their ability to synthesize and logically…

Computation and Language · Computer Science 2024-07-31 Tianshi Zheng , Jiaxin Bai , Yicheng Wang , Tianqing Fang , Yue Guo , Yauwai Yim , Yangqiu Song

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Computation and Language · Computer Science 2024-06-07 Anand Subramanian , Viktor Schlegel , Abhinav Ramesh Kashyap , Thanh-Tung Nguyen , Vijay Prakash Dwivedi , Stefan Winkler

Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual…

Computation and Language · Computer Science 2025-02-06 Seonok Kim

Large Language Models (LLMs) have shown promising performance in knowledge-intensive reasoning tasks that require a compound understanding of knowledge. However, deployment of the LLMs in real-world applications can be challenging due to…

Computation and Language · Computer Science 2023-10-31 Minki Kang , Seanie Lee , Jinheon Baek , Kenji Kawaguchi , Sung Ju Hwang

Medical vision-language models (VLMs) achieve strong performance in diagnostic reporting and image-text alignment, yet their underlying reasoning mechanisms remain fundamentally correlational, exhibiting reliance on superficial statistical…

Machine Learning · Computer Science 2026-01-27 Weiqin Yang , Haowen Xue , Qingyi Peng , Hexuan Hu , Qian Huang , Tingbo Zhang

Large-scale language models (LLMs) have achieved remarkable success across various language tasks but suffer from hallucinations and temporal misalignment. To mitigate these shortcomings, Retrieval-augmented generation (RAG) has been…

Computation and Language · Computer Science 2024-04-30 Zhongzhen Huang , Kui Xue , Yongqi Fan , Linjie Mu , Ruoyu Liu , Tong Ruan , Shaoting Zhang , Xiaofan Zhang

Clinical diagnosis begins with doctor-patient interaction, during which physicians iteratively gather information, determine examination and refine differential diagnosis through patients' response. This dynamic clinical-reasoning process…

Computation and Language · Computer Science 2025-12-30 Yuqi Tang , Jing Yu , Zichang Su , Kehua Feng , Zhihui Zhu , Libin Wang , Lei Liang , Qiang Zhang , Keyan Ding , Huajun Chen

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

Artificial Intelligence · Computer Science 2025-02-24 Brian Hyeongseok Kim , Chao Wang

Large Language Models (LLMs) have shown remarkable capabilities in general domains but often struggle with tasks requiring specialized knowledge. Conventional Retrieval-Augmented Generation (RAG) techniques typically retrieve external…

Computation and Language · Computer Science 2025-02-20 Yucheng Shi , Tianze Yang , Canyu Chen , Quanzheng Li , Tianming Liu , Xiang Li , Ninghao Liu

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Small Language Models (SLMs) are becoming increasingly popular in specialized fields, such as industrial applications, due to their efficiency, lower computational requirements, and ability to be fine-tuned for domain-specific tasks,…

Computation and Language · Computer Science 2025-10-22 Shuxin Lin , Dhaval Patel , Christodoulos Constantinides

Recent advances in large language models (LLMs) have shown potential in clinical text summarization, but their ability to handle long patient trajectories with multi-modal data spread across time remains underexplored. This study…

Computation and Language · Computer Science 2025-09-08 Maya Kruse , Shiyue Hu , Nicholas Derby , Yifu Wu , Samantha Stonbraker , Bingsheng Yao , Dakuo Wang , Elizabeth Goldberg , Yanjun Gao

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

With the rapid growth of large language models (LLMs) and vision-language models (VLMs) in medicine, simply integrating clinical text and medical imaging does not guarantee reliable reasoning. Existing multimodal models often produce…

Artificial Intelligence · Computer Science 2025-12-29 Zelin Zang , Wenyi Gu , Siqi Ma , Dan Yang , Yue Shen , Zhu Zhang , Guohui Fan , Wing-Kuen Ling , Fuji Yang

Clinical reasoning refers to the cognitive process that physicians employ in evaluating and managing patients. This process typically involves suggesting necessary examinations, diagnosing patients' diseases, and deciding on appropriate…

Computation and Language · Computer Science 2024-06-11 Jiageng WU , Xian Wu , Jie Yang

Large Language Models (LLMs) have demonstrated remarkable success in diverse natural language processing (NLP) tasks in general domains. However, LLMs sometimes generate responses with the hallucination about medical facts due to limited…

Computation and Language · Computer Science 2025-01-14 Haochun Wang , Sendong Zhao , Zewen Qiang , Zijian Li , Nuwa Xi , Yanrui Du , MuZhen Cai , Haoqiang Guo , Yuhan Chen , Haoming Xu , Bing Qin , Ting Liu