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Clinical trials are typically run in order to understand the effects of a new treatment on a given population of patients. However, patients in large populations rarely respond the same way to the same treatment. This heterogeneity in…

Machine Learning · Statistics 2024-02-12 Alihan Hüyük , Zhaozhi Qian , Mihaela van der Schaar

Access to individual-level health data is essential for gaining new insights and advancing science. In particular, modern methods based on artificial intelligence rely on the availability of and access to large datasets. In the health…

The integration of Reinforcement Learning (RL) into robotic-assisted surgery (RAS) holds significant promise for advancing surgical precision, adaptability, and autonomous decision-making. However, the development of robust RL models in…

Robotics · Computer Science 2025-10-30 Sana Hafeez , Sundas Rafat Mulkana , Muhammad Ali Imran , Michele Sevegnani

Access to real-world medical data is often restricted due to privacy regulations, posing a significant barrier to the advancement of healthcare research. Synthetic data offers a promising alternative; however, generating realistic,…

Artificial Intelligence · Computer Science 2025-08-13 Arshia Ilaty , Hossein Shirazi , Hajar Homayouni

Vision-language models (VLMs) trained via reinforcement learning with verifiable reward (RLVR) have shown notable progress in scaling test-time compute effectively. In this work, we investigate how synthesized RL data can further improve…

Machine Learning · Computer Science 2025-06-04 Zijian Wu , Jinjie Ni , Xiangyan Liu , Zichen Liu , Hang Yan , Michael Qizhe Shieh

Synthetic data generation is a powerful tool for privacy protection when considering public release of record-level data files. Initially proposed about three decades ago, it has generated significant research and application interest. To…

Methodology · Statistics 2023-08-03 Jingchen Hu , Claire McKay Bowen

Synthetic health data have the potential to mitigate privacy concerns when sharing data to support biomedical research and the development of innovative healthcare applications. Modern approaches for data generation based on machine…

Machine Learning · Computer Science 2023-01-11 Chao Yan , Yao Yan , Zhiyu Wan , Ziqi Zhang , Larsson Omberg , Justin Guinney , Sean D. Mooney , Bradley A. Malin

Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

There is a need for synthetic training and test datasets that replicate statistical distributions of original datasets without compromising their confidentiality. A lot of research has been done in leveraging Generative Adversarial Networks…

Machine Learning · Computer Science 2026-02-06 Laura Plein , Alexi Turcotte , Arina Hallemans , Andreas Zeller

While large language models hold promise for complex medical applications, their development is hindered by the scarcity of high-quality reasoning data. To address this issue, existing approaches typically distill chain-of-thought reasoning…

Machine Learning · Computer Science 2026-04-14 Haolin Li , Shuyang Jiang , Ruipeng Zhang , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Synthetic data has gained significant momentum thanks to sophisticated machine learning tools that enable the synthesis of high-dimensional datasets. However, many generation techniques do not give the data controller control over what…

Cryptography and Security · Computer Science 2022-11-22 Florimond Houssiau , Samuel N. Cohen , Lukasz Szpruch , Owen Daniel , Michaela G. Lawrence , Robin Mitra , Henry Wilde , Callum Mole

Machine learning heavily relies on data, but real-world applications often encounter various data-related issues. These include data of poor quality, insufficient data points leading to under-fitting of machine learning models, and…

Machine Learning · Computer Science 2025-04-07 Yingzhou Lu , Lulu Chen , Yuanyuan Zhang , Minjie Shen , Huazheng Wang , Xiao Wang , Capucine van Rechem , Tianfan Fu , Wenqi Wei

A key theme in the past decade has been that when large neural networks and large datasets combine they can produce remarkable results. In deep reinforcement learning (RL), this paradigm is commonly made possible through experience replay,…

Machine Learning · Computer Science 2023-10-30 Cong Lu , Philip J. Ball , Yee Whye Teh , Jack Parker-Holder

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Reinforcement learning has been shown to improve the performance of large language models. However, traditional approaches like RLHF or RLAIF treat the problem as single-step. As focus shifts toward more complex reasoning and agentic tasks,…

Artificial Intelligence · Computer Science 2025-04-29 Anna Goldie , Azalia Mirhoseini , Hao Zhou , Irene Cai , Christopher D. Manning

Privacy concerns around sharing personally identifiable information are a major practical barrier to data sharing in medical research. However, in many cases, researchers have no interest in a particular individual's information but rather…

Image and Video Processing · Electrical Eng. & Systems 2021-08-18 August DuMont Schütte , Jürgen Hetzel , Sergios Gatidis , Tobias Hepp , Benedikt Dietz , Stefan Bauer , Patrick Schwab

In the current data driven era, synthetic data, artificially generated data that resembles the characteristics of real world data without containing actual personal information, is gaining prominence. This is due to its potential to…

Machine Learning · Computer Science 2023-09-06 Tshilidzi Marwala , Eleonore Fournier-Tombs , Serge Stinckwich

The rapid advancements in generative AI and large language models (LLMs) have opened up new avenues for producing synthetic data, particularly in the realm of structured tabular formats, such as product reviews. Despite the potential…

Machine Learning · Computer Science 2025-07-25 Yefeng Yuan , Yuhong Liu , Liang Cheng

The switch from a Model-Centric to a Data-Centric mindset is putting emphasis on data and its quality rather than algorithms, bringing forward new challenges. In particular, the sensitive nature of the information in highly regulated…

Machine Learning · Computer Science 2022-04-14 Giorgio Visani , Giacomo Graffi , Mattia Alfero , Enrico Bagli , Davide Capuzzo , Federico Chesani

Synthetic data offers a promising path to train models while preserving data privacy. Differentially private (DP) finetuning of large language models (LLMs) as data generator is effective, but is impractical when computation resources are…

Computation and Language · Computer Science 2025-07-18 Bowen Tan , Zheng Xu , Eric Xing , Zhiting Hu , Shanshan Wu