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Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational…

Machine Learning · Computer Science 2018-06-27 Anirban Mukhopadhyay

The escalating integration of machine learning in high-stakes fields such as healthcare raises substantial concerns about model fairness. We propose an interpretable framework - Fairness-Aware Interpretable Modeling (FAIM), to improve model…

Machine Learning · Computer Science 2024-03-11 Mingxuan Liu , Yilin Ning , Yuhe Ke , Yuqing Shang , Bibhas Chakraborty , Marcus Eng Hock Ong , Roger Vaughan , Nan Liu

We propose Automatic Feature Explanation using Contrasting Concepts (FALCON), an interpretability framework to explain features of image representations. For a target feature, FALCON captions its highly activating cropped images using a…

Computer Vision and Pattern Recognition · Computer Science 2023-09-11 Neha Kalibhat , Shweta Bhardwaj , Bayan Bruss , Hamed Firooz , Maziar Sanjabi , Soheil Feizi

Improving the interpretability of brain decoding approaches is of primary interest in many neuroimaging studies. Despite extensive studies of this type, at present, there is no formal definition for interpretability of brain decoding…

Machine Learning · Statistics 2016-06-21 Seyed Mostafa Kia , Andrea Passerini

The use of machine learning (ML) techniques in the biomedical field has become increasingly important, particularly with the large amounts of data generated by the aftermath of the COVID-19 pandemic. However, due to the complex nature of…

Machine Learning · Computer Science 2023-03-17 Anthony Onoja , Francesco Raimondi

Recently, large models have shown significant potential for smart healthcare. However, the deployment of Large Vision-Language Models (LVLMs) for clinical services is currently hindered by three critical challenges: a tendency to…

Artificial Intelligence · Computer Science 2025-10-27 Siyong Chen , Jinbo Wen , Jiawen Kang , Tenghui Huang , Xumin Huang , Yuanjia Su , Hudan Pan , Zishao Zhong , Dusit Niyato , Shengli Xie , Dong In Kim

We introduce MATEX (Multi-scale Attention and Text-guided Explainability), a novel framework that advances interpretability in medical vision-language models by incorporating anatomically informed spatial reasoning. MATEX synergistically…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Muhammad Imran , Chi Lee , Yugyung Lee

Medical concept extraction from electronic health records underpins many downstream applications, yet remains challenging because medically meaningful concepts are frequently implied rather than explicitly stated in medical narratives.…

Computation and Language · Computer Science 2026-05-21 Zhichao Yang , Gregory D. Lyng , Sanjit Singh Batra , Robert E. Tillman

The healthcare domain is one of the most exciting application areas for machine learning, but a lack of model transparency contributes to a lag in adoption within the industry. In this work, we explore the current art of explainability and…

Computation and Language · Computer Science 2021-07-14 Mitchell Naylor , Christi French , Samantha Terker , Uday Kamath

Interpretability is crucial for building safe, reliable, and controllable language models, yet existing interpretability pipelines remain costly and difficult to scale. Interpreting a new model typically requires training model-specific…

Machine Learning · Computer Science 2026-04-27 Bruno Puri , Jim Berend , Sebastian Lapuschkin , Wojciech Samek

The ubiquity of neural networks (NNs) in real-world applications, from healthcare to natural language processing, underscores their immense utility in capturing complex relationships within high-dimensional data. However, NNs come with…

Machine Learning · Computer Science 2024-07-08 Chang Yue , Niraj K. Jha

Multi-modal Large Language Models (MLLMs) have demonstrated remarkable capabilities in understanding and generating content across various modalities, such as images and text. However, their interpretability remains a challenge, hindering…

Computer Vision and Pattern Recognition · Computer Science 2024-05-29 Loris Giulivi , Giacomo Boracchi

Domain gaps arising from variations in imaging devices and population distributions pose significant challenges for machine learning in medical image analysis. Existing image-to-image translation methods primarily aim to learn mappings…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Tianyang Zhang , Xinxing Cheng , Jun Cheng , Shaoming Zheng , He Zhao , Huazhu Fu , Alejandro F Frangi , Jiang Liu , Jinming Duan

Understanding AI systems' inner workings is critical for ensuring value alignment and safety. This review explores mechanistic interpretability: reverse engineering the computational mechanisms and representations learned by neural networks…

Artificial Intelligence · Computer Science 2024-08-27 Leonard Bereska , Efstratios Gavves

Neural network interpretability is a vital component for applications across a wide variety of domains. In such cases it is often useful to analyze a network which has already been trained for its specific purpose. In this work, we develop…

Machine Learning · Computer Science 2019-11-19 Lawrence Phillips , Garrett Goh , Nathan Hodas

The proliferation of high-dimensional datasets in fields such as genomics, healthcare, and finance has created an urgent need for machine learning models that are both highly accurate and inherently interpretable. While traditional deep…

Machine Learning · Computer Science 2025-10-28 Rekha R Nair , Tina Babu , Alavikunhu Panthakkan , Hussain Al-Ahmad , Balamurugan Balusamy

Interpretability has emerged as a crucial aspect of building trust in machine learning systems, aimed at providing insights into the working of complex neural networks that are otherwise opaque to a user. There are a plethora of existing…

Machine Learning · Statistics 2021-01-19 Rushil Anirudh , Jayaraman J. Thiagarajan , Rahul Sridhar , Peer-Timo Bremer

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

Medical Large Vision-Language Models (Med-LVLMs) have shown promising results in clinical applications, but often suffer from hallucinated outputs due to misaligned visual understanding. In this work, we identify two fundamental limitations…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Aofei Chang , Ting Wang , Fenglong Ma

Concept Bottleneck Models (CBMs) are a prominent framework for interpretable AI that map learned visual features to a set of meaningful concepts for task-specific downstream predictions. Their sequential structure enhances transparency by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Mohamed Harmanani , Bining Long , Zhuoxin Guo , Paul F. R. Wilson , Amirhossein Sabour , Minh Nguyen Nhat To , Gabor Fichtinger , Purang Abolmaesumi , Parvin Mousavi
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