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The field of machine learning has seen tremendous progress in recent years, with deep learning models delivering exceptional performance across a range of tasks. However, these models often come at the cost of interpretability, as they…

Machine Learning · Computer Science 2024-01-08 Shun Liu

Mechanistic interpretability (MI) is an emerging sub-field of interpretability that seeks to understand a neural network model by reverse-engineering its internal computations. Recently, MI has garnered significant attention for…

Artificial Intelligence · Computer Science 2025-10-14 Daking Rai , Yilun Zhou , Shi Feng , Abulhair Saparov , Ziyu Yao

Explainability is critical for the clinical adoption of medical visual question answering (VQA) systems, as physicians require transparent reasoning to trust AI-generated diagnoses. We present MedXplain-VQA, a comprehensive framework…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Hai-Dang Nguyen , Minh-Anh Dang , Minh-Tan Le , Minh-Tuan Le

Interpretable brain network models for disease prediction are of great value for the advancement of neuroscience. GNNs are promising to model complicated network data, but they are prone to overfitting and suffer from poor interpretability,…

Machine Learning · Computer Science 2021-07-13 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Medical Image Computing (MIC) is a broad research topic covering both pixel-wise (e.g., segmentation, registration) and image-wise (e.g., classification, regression) vision tasks. Effective analysis demands models that capture both global…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Mingyuan Meng

Mechanistic Interpretability (MI) promises a path toward fully understanding how neural networks make their predictions. Prior work demonstrates that even when trained to perform simple arithmetic, models can implement a variety of…

Machine Learning · Computer Science 2024-05-28 Ouail Kitouni , Niklas Nolte , Víctor Samuel Pérez-Díaz , Sokratis Trifinopoulos , Mike Williams

Part-prototype models are explainable-by-design image classifiers, and a promising alternative to black box AI. This paper explores the applicability and potential of interpretable machine learning, in particular PIP-Net, for automated…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Meike Nauta , Johannes H. Hegeman , Jeroen Geerdink , Jörg Schlötterer , Maurice van Keulen , Christin Seifert

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

Medical Image Hierarchical Multi-Label Classification (MI-HMC) is of paramount importance in modern healthcare, presenting two significant challenges: data imbalance and \textit{hierarchy constraint}. Existing solutions involve complex…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 Meng Wu , Siyan Luo , Qiyu Wu , Wenbin Ouyang

The modeling and simulation of high-dimensional multiscale systems is a critical challenge across all areas of science and engineering. It is broadly believed that even with today's computer advances resolving all spatiotemporal scales…

Machine Learning · Statistics 2023-09-13 Emmanuel Menier , Sebastian Kaltenbach , Mouadh Yagoubi , Marc Schoenauer , Petros Koumoutsakos

Recently, artificial intelligence and machine learning in general have demonstrated remarkable performances in many tasks, from image processing to natural language processing, especially with the advent of deep learning. Along with…

Machine Learning · Computer Science 2020-10-23 Erico Tjoa , Cuntai Guan

Interpretability has become an essential topic for artificial intelligence in some high-risk domains such as healthcare, bank and security. For commonly-used tabular data, traditional methods trained end-to-end machine learning models with…

Artificial Intelligence · Computer Science 2022-08-18 Haixiao Chi , Dawei Wang , Gaojie Cui , Feng Mao , Beishui Liao

Despite remarkable advancements in pixel-level medical image perception, existing methods are either limited to specific tasks or heavily rely on accurate bounding boxes or text labels as input prompts. However, the medical knowledge…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Qinyue Tong , Ziqian Lu , Jun Liu , Yangming Zheng , Zheming Lu

Medical Vision-Language Models (Med-VLMs) have achieved expert-level proficiency in interpreting diagnostic imaging. However, current models are predominantly trained on professional literature, limiting their ability to communicate…

Computation and Language · Computer Science 2026-04-08 Han Jang , Junhyeok Lee , Heeseong Eum , Kyu Sung Choi

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises…

Would you trust physicians if they cannot explain their decisions to you? Medical diagnostics using machine learning gained enormously in importance within the last decade. However, without further enhancements many state-of-the-art machine…

Machine Learning · Computer Science 2022-06-01 Emanuel Slany , Yannik Ott , Stephan Scheele , Jan Paulus , Ute Schmid

Interpretability of machine learning models is critical for data-driven precision medicine efforts. However, highly predictive models are generally complex and are difficult to interpret. Here using Model-Agnostic Explanations algorithm, we…

Quantitative Methods · Quantitative Biology 2016-10-31 Gajendra Jung Katuwal , Robert Chen

The scarcity of annotated data in specialized domains such as medical imaging presents significant challenges to training robust vision models. While self-supervised masked image modeling (MIM) offers a promising solution, existing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Ruilang Wang , Shuotong Xu , Bowen Liu , Runlin Huang , Donglong Chen , Weifeng Su

In this paper, we present a novel approach for medical synonym extraction. We aim to integrate the term embedding with the medical domain knowledge for healthcare applications. One advantage of our method is that it is very scalable.…

Computation and Language · Computer Science 2015-06-02 Chang Wang , Liangliang Cao , Bowen Zhou

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques