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Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. The extracellular accumulation of amyloid-$\beta$ (A$\beta$) in senile plaques is a principal event in the pathogenesis and there…

Medical Physics · Physics 2018-03-12 E. G. Lobanova , S. V. Lobanov , K. Triantafilou , W. Langbein , P. Borri

In medical imaging, image synthesis is the estimation process of one image (sequence, modality) from another image (sequence, modality). Since images with different modalities provide diverse biomarkers and capture various features,…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Firoozeh Shomal Zadeh , Sevda Molani , Maysam Orouskhani , Marziyeh Rezaei , Mehrzad Shafiei , Hossein Abbasi

Although cancer patients survive years after oncologic therapy, they are plagued with long-lasting or permanent residual symptoms, whose severity, rate of development, and resolution after treatment vary largely between survivors. The…

Early diagnosis of Alzheimer's disease (AD) is critical for intervention before irreversible neurodegeneration occurs. Structural MRI (sMRI) is widely used for AD diagnosis, but conventional deep learning approaches primarily rely on…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Shijia Zhang , Xiyu Ding , Brian Caffo , Junyu Chen , Cindy Zhang , Hadi Kharrazi , Zheyu Wang

3D brain MRI studies often examine subtle morphometric differences between cohorts that are hard to detect visually. Given the high cost of MRI acquisition, these studies could greatly benefit from image syntheses, particularly…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Binxu Li , Wei Peng , Mingjie Li , Ehsan Adeli , Kilian M. Pohl

Medical imaging plays a critical role in various clinical applications. However, due to multiple considerations such as cost and risk, the acquisition of certain image modalities could be limited. To address this issue, many cross-modality…

Image and Video Processing · Electrical Eng. & Systems 2019-07-09 Dong Nie , Lei Xiang , Qian Wang , Dinggang Shen

The use of neural networks for diagnosis classification is becoming more and more prevalent in the medical imaging community. However, deep learning method outputs remain hard to explain. Another difficulty is to choose among the large…

Image and Video Processing · Electrical Eng. & Systems 2020-02-11 Elina Thibeau Sutre , Olivier Colliot , Didier Dormont , Ninon Burgos

This study presents an innovative method for Alzheimer's disease diagnosis using 3D MRI designed to enhance the explainability of model decisions. Our approach adopts a soft attention mechanism, enabling 2D CNNs to extract volumetric…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano

The promising research on Artificial Intelligence usages in suicide prevention has principal gaps, including black box methodologies, inadequate outcome measures, and scarce research on non-verbal inputs, such as social media images…

Artificial Intelligence · Computer Science 2023-02-21 Yael Badian , Yaakov Ophir , Refael Tikochinski , Nitay Calderon , Anat Brunstein Klomek , Roi Reichart

Predicting conversion from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) is critical for early intervention. Current deep learning paradigms predominantly rely on cross-sectional structural MRI, neglecting prognostic value in…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Alireza Moayedikia , Sara Fin , Alicia Troncoso Lora , Uffe Kock Wiil

Alzheimer's disease (AD), the predominant form of dementia, is a growing global challenge, emphasizing the urgent need for accurate and early diagnosis. Current clinical diagnoses rely on radiologist expert interpretation, which is prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Simisola Odimayo , Chollette C. Olisah , Khadija Mohammed

Alzheimer's disease (AD) is the most common type of dementia accompanied with brain atrophy. Structural measurements of brain atrophy in specific brain structures such as hippocampus using magnetic resonance imaging (MRI) have been reported…

Medical Physics · Physics 2016-05-10 Kenya Murase , Naohiko Gondo , Tsutomu Soma

Alzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage such that intervention can be applied before…

Machine Learning · Computer Science 2024-09-02 Yipei Wang , Bing He , Shannon Risacher , Andrew Saykin , Jingwen Yan , Xiaoqian Wang

Human organs constantly undergo anatomical changes due to a complex mix of short-term (e.g., heartbeat) and long-term (e.g., aging) factors. Evidently, prior knowledge of these factors will be beneficial when modeling their future state,…

Computer Vision and Pattern Recognition · Computer Science 2023-06-19 Jee Seok Yoon , Chenghao Zhang , Heung-Il Suk , Jia Guo , Xiaoxiao Li

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Gregory Holste , Mingquan Lin , Ruiwen Zhou , Fei Wang , Lei Liu , Qi Yan , Sarah H. Van Tassel , Kyle Kovacs , Emily Y. Chew , Zhiyong Lu , Zhangyang Wang , Yifan Peng

Longitudinal MRI is an important diagnostic imaging tool for evaluating the effects of treatment and monitoring disease progression. However, MRI, and particularly longitudinal MRI, is known to be time consuming. To accelerate imaging,…

Image and Video Processing · Electrical Eng. & Systems 2023-01-24 Jens Renders , Banafshe Shafieizargar , Marleen Verhoye , Jan De Beenhouwer , Arnold J. den Dekker , Jan Sijbers

Reliable Alzheimer's disease (AD) diagnosis increasingly relies on multimodal assessments combining structural Magnetic Resonance Imaging (MRI) and Electronic Health Records (EHR). However, deploying these models is bottlenecked by modality…

Computer Vision and Pattern Recognition · Computer Science 2026-03-04 Guanchen Wu , Zhe Huang , Yuzhang Xie , Runze Yan , Akul Chopra , Deqiang Qiu , Xiao Hu , Fei Wang , Carl Yang

Challenges such as the lack of high-quality annotations, long-tailed data distributions, and inconsistent staining styles pose significant obstacles to training neural networks to detect abnormal cells in cytopathology robustly. This paper…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Qiuyi Qi , Xin Li , Ming Kong , Zikang Xu , Bingdi Chen , Qiang Zhu , S Kevin Zhou

Despite the recent success in applying supervised deep learning to medical imaging tasks, the problem of obtaining large and diverse expert-annotated datasets required for the development of high performant models remains particularly…

Computer Vision and Pattern Recognition · Computer Science 2019-11-21 Amirata Ghorbani , Vivek Natarajan , David Coz , Yuan Liu

Deep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of healthcare. This study focuses on…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Nida Nasir , Muneeb Ahmed , Neda Afreen , Mustafa Sameer