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Medical imaging datasets are inherently high dimensional with large variability and low sample sizes that limit the effectiveness of deep learning algorithms. Recently, generative adversarial networks (GANs) with the ability to synthesize…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Apoorva Sikka , Skand Peri , Jitender Singh Virk , Usma Niyaz , Deepti R. Bathula

Through recognizing causal subgraphs, causal graph learning (CGL) has risen to be a promising approach for improving the generalizability of graph neural networks under out-of-distribution (OOD) scenarios. However, the empirical successes…

Machine Learning · Computer Science 2025-07-02 Yujia Yin , Tianyi Qu , Zihao Wang , Yifan Chen

Causal reasoning provides a language to ask important interventional and counterfactual questions beyond purely statistical association. In medical imaging, for example, we may want to study the causal effect of genetic, environmental, or…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Rajat Rasal , Daniel C. Castro , Nick Pawlowski , Ben Glocker

The image-based diagnosis is now a vital aspect of modern automation assisted diagnosis. To enable models to produce pixel-level diagnosis, pixel-level ground-truth labels are essentially required. However, since it is often not straight…

Computer Vision and Pattern Recognition · Computer Science 2023-01-24 Tehseen Zia , Zeeshan Nisar , Shakeeb Murtaza

Alzheimer's disease (AD) is an irreversible neurode generative disease of the brain.The disease may causes memory loss, difficulty communicating and disorientation. For the diagnosis of Alzheimer's disease, a series of scales are often…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Yelu Gao , Huang Huang , Lian Zhang

Alzheimer's disease (AD) is characterized by complex and largely unknown progression dynamics affecting the brain's morphology. Although the disease evolution spans decades, to date we cannot rely on long-term data to model the pathological…

Applications · Statistics 2019-08-14 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

The preclinical stage of many neurodegenerative diseases can span decades before symptoms become apparent. Understanding the sequence of preclinical biomarker changes provides a critical opportunity for early diagnosis and effective…

Methodology · Statistics 2024-06-11 Yizhen Xu , Scott Zeger , Zheyu Wang

Alzheimer's Disease destroys brain cells causing people to lose their memory, mental functions and ability to continue daily activities. It is a severe neurological brain disorder which is not curable, but earlier detection of Alzheimer's…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 Jyoti Islam , Yanqing Zhang

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu

Physical and optical factors interacting with sensor characteristics create complex image degradation patterns. Despite advances in deep learning-based super-resolution, existing methods overlook the causal nature of degradation by adopting…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Zhengyang Lu , Bingjie Lu , Feng Wang

Understanding the latent causal factors of a dynamical system from visual observations is considered a crucial step towards agents reasoning in complex environments. In this paper, we propose CITRIS, a variational autoencoder framework that…

Machine Learning · Computer Science 2022-06-16 Phillip Lippe , Sara Magliacane , Sindy Löwe , Yuki M. Asano , Taco Cohen , Efstratios Gavves

Deep learning methods, and in particular convolutional neural networks (CNNs), have led to an enormous breakthrough in a wide range of computer vision tasks, primarily by using large-scale annotated datasets. However, obtaining such…

Computer Vision and Pattern Recognition · Computer Science 2019-01-23 Maayan Frid-Adar , Idit Diamant , Eyal Klang , Michal Amitai , Jacob Goldberger , Hayit Greenspan

Alzheimer's Disease (AD) is a neurodegenerative condition characterized by diverse progression rates among individuals, with changes in cortical thickness (CTh) closely linked to its progression. Accurately forecasting CTh trajectories can…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Qing Xiao , Siyeop Yoon , Hui Ren , Matthew Tivnan , Lichao Sun , Quanzheng Li , Tianming Liu , Yu Zhang , Xiang Li

Curating a large scale medical imaging dataset for machine learning applications is both time consuming and expensive. Balancing the workload between model development, data collection and annotations is difficult for machine learning…

Artificial Intelligence · Computer Science 2022-06-07 Athanasios Vlontzos , Hadrien Reynaud , Bernhard Kainz

Difference-in-Differences (DiD) is a widely used research design that often relies on a conditional parallel trends (CPT) assumption. In contrast to settings with unconfoundedness, where causal graphs provide powerful frameworks for…

Econometrics · Economics 2026-04-15 Michael C. Knaus , Henri Pfleiderer

Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in Alzheimer's disease (AD). Traditional survival models often…

Applications · Statistics 2025-03-24 Dhrubajyoti Ghosh , Samhita Pal , Michael Lutz , Sheng Luo

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major cause of dementia. Structural MRI is widely used to analyze AD-related brain atrophy; however, most deep learning methods rely on computationally expensive 3D…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Towhidul Islam , Mufti Mahmud

Identifying causal interactions in complex dynamical systems is a fundamental challenge across the computational sciences. Existing functional connectivity methods capture correlations but not causation. While addressing directionality,…

Neurons and Cognition · Quantitative Biology 2026-03-10 Rahul Biswas , SuryaNarayana Sripada , Somabha Mukherjee , Reza Abbasi-Asl

Accurate modeling of cognitive decline in Alzheimer's disease is essential for early stratification and personalized management. While tabular predictors provide robust markers of global risk, their ability to capture subtle brain changes…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Nathaniel Putera , Daniel Vilet Rodríguez , Noah Videcrantz , Julia Machnio , Mostafa Mehdipour Ghazi