Related papers: Zimin patterns in genomes
We extend the classical Ostrowski numeration systems, closely related to Sturmian words, by allowing a wider range of coefficients, so that possible representations of a number $n$ better reflect the structure of the associated Sturmian…
Given a set $\Pi$ of permutation patterns of length at most $k$, we present an algorithm for building $S_{\le n}(\Pi)$, the set of permutations of length at most $n$ avoiding the patterns in $\Pi$, in time $O(|S_{\le n - 1}(\Pi)| \cdot k +…
Single-nucleotide polymorphisms (SNPs) account for most variations between human genomes. We show how, if the genomes in a database differ only by a reasonable number of SNPs and the substrings between those SNPs are unique, then we can…
The isolation-with-migration (IM) model is a common tool to make inferences about the presence of gene flow during speciation, using polymorphism data. However, Becquet and Przeworski (2009) report that the parameter estimates obtained by…
Secondary contact between divergent populations or incipient species may result in the exchange and introgression of genomic material. We develop a simple DNA sequence measure, called Gmin, which is designed to identify genomic regions…
Recently, Babson and Steingrimsson have introduced generalised permutation patterns that allow the requirement that two adjacent letters in a pattern must be adjacent in the permutation. We consider pattern avoidance for such patterns, and…
DNA strings and their properties are widely studied since last 20 years due to its applications in DNA computing. In this area, one designs a set of DNA strings (called DNA code) which satisfies certain thermodynamic and combinatorial…
Background: In addition to known protein-coding genes, large amount of apparently non-coding sequence are conserved between the human and mouse genomes. It seems reasonable to assume that these conserved regions are more likely to contain…
The algebraic structures of the genetic code are most important to obtain additional information about the semantic code and its applications. In this paper we define two dual Boolean codon lattices of the genetic code using hydrogen bond…
Let T_k^m={\sigma \in S_k | \sigma_1=m}. We prove that the number of permutations which avoid all patterns in T_k^m equals (k-2)!(k-1)^{n+1-k} for k <= n. We then prove that for any \tau in T_k^1 (or any \tau in T_k^k), the number of…
The observed frequency of the longest proper prefix, the longest proper suffix, and the longest infix of a word $w$ in a given sequence $x$ can be used for classifying $w$ as avoided or overabundant. The definitions used for the expectation…
In combinatorics on words, a word $w$ over an alphabet $\Sigma$ is said to avoid a pattern $p$ over an alphabet $\Delta$ of variables if there is no factor $f$ of $w$ such that $f=h(p)$ where $h:\Delta^*\to\Sigma^*$ is a non-erasing…
The Z_64-algebra of the genetic code and DNA sequences of length N was recently stated. In order to beat the limits of this structure such as the impossibility of non-coding region analysis in genomes and the impossibility of the insertions…
We raise the question of approximating the compressibility of a string with respect to a fixed compression scheme, in sublinear time. We study this question in detail for two popular lossless compression schemes: run-length encoding (RLE)…
Relative Lempel-Ziv (RLZ) is a popular algorithm for compressing databases of genomes from individuals of the same species when fast random access is desired. With Kuruppu et al.'s (SPIRE 2010) original implementation, a reference genome is…
Finding an Approximate Longest Common Substring (ALCS) within a given set $S=\{s_1,s_2,\ldots,s_m\}$ of $m \ge 2$ strings is a key problem in computational biology, such as identifying related mutations across multiple genetic sequences. We…
The human genome remains incomplete, with multi-megabase sized gaps representing the endogenous centromeres and other heterochromatic regions. These regions are commonly enriched with long arrays of near-identical tandem repeats, known as…
We consider a random permutation drawn from the set of permutations of length $n$ that avoid some given set of patterns of length 3. We show that the number of occurrences of another pattern $\sigma$ has a limit distribution, after suitable…
Melanins are a group of complex pigments of biological origin, widely spread in all species from fungi to man. Among diverse types of melanins, the human melanins, eumelanins,are brown or black nitrogen-containing pigments, mostly known for…
We introduce an improved version of RECKONER, an error corrector for Illumina whole genome sequencing data. By modifying its workflow we reduce the computation time even 10 times. We also propose a new method of determination of $k$-mer…