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Clinical Question Answering (CQA) plays a crucial role in medical decision-making, enabling physicians to extract relevant information from Electronic Medical Records (EMRs). While transformer-based models such as BERT, BioBERT, and…

Computation and Language · Computer Science 2025-04-24 Priyaranjan Pattnayak , Hitesh Laxmichand Patel , Amit Agarwal , Bhargava Kumar , Srikant Panda , Tejaswini Kumar

Large Language Models (LLMs) have recently gained attention in the life sciences due to their capacity to model, extract, and apply complex biological information. Beyond their classical use as chatbots, these systems are increasingly used…

Computation and Language · Computer Science 2025-07-03 Baqer M. Merzah , Tania Taami , Salman Asoudeh , Saeed Mirzaee , Amir reza Hossein pour , Amir Ali Bengari

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

Clinical problem-solving requires processing of semantic medical knowledge such as illness scripts and numerical medical knowledge of diagnostic tests for evidence-based decision-making. As large language models (LLMs) show promising…

This paper surveys the development of large language model (LLM)-based agents for question answering (QA). Traditional agents face significant limitations, including substantial data requirements and difficulty in generalizing to new…

Computation and Language · Computer Science 2025-03-26 Murong Yue

Medical question answer (QA) assistants respond to lay users' health-related queries by synthesizing information from multiple sources using natural language processing and related techniques. They can serve as vital tools to alleviate…

Computation and Language · Computer Science 2024-10-01 Prakash Chandra Sukhwal , Vaibhav Rajan , Atreyi Kankanhalli

A question-answering (QA) system is to search suitable answers within a knowledge base. Current QA systems struggle with queries requiring complex reasoning or real-time knowledge integration. They are often supplemented with retrieval…

Computation and Language · Computer Science 2025-05-21 Sizhe Yuen , Ting Su , Ziyang Wang , Yali Du , Adam J. Sobey

Effective Question Answering (QA) on large biomedical document collections requires effective document retrieval techniques. The latter remains a challenging task due to the domain-specific vocabulary and semantic ambiguity in user queries.…

Information Retrieval · Computer Science 2025-08-19 Zabir Al Nazi , Vagelis Hristidis , Aaron Lawson McLean , Jannat Ara Meem , Md Taukir Azam Chowdhury

Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

Large Language Models (LLMs) have demonstrated immense potential in artificial intelligence across various domains, including healthcare. However, their efficacy is hindered by the need for high-quality labeled data, which is often…

Computation and Language · Computer Science 2024-05-24 P. Barai , G. Leroy , P. Bisht , J. M. Rothman , S. Lee , J. Andrews , S. A. Rice , A. Ahmed

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

This paper reviews the state-of-the-art of large language models (LLM) architectures and strategies for "complex" question-answering with a focus on hybrid architectures. LLM based chatbot services have allowed anyone to grasp the potential…

Computation and Language · Computer Science 2025-11-04 Xavier Daull , Patrice Bellot , Emmanuel Bruno , Vincent Martin , Elisabeth Murisasco

Objectives: To adapt and evaluate a deep learning language model for answering why-questions based on patient-specific clinical text. Materials and Methods: Bidirectional encoder representations from transformers (BERT) models were trained…

Computation and Language · Computer Science 2020-03-09 Andrew Wen , Mohamed Y. Elwazir , Sungrim Moon , Jungwei Fan

Large language models (LLMs) have shown promise in medical question answering, yet they often overlook the domain-specific expertise that professionals depend on, such as the clinical subject areas (e.g., trauma, airway) and the…

Computation and Language · Computer Science 2025-11-20 Xueren Ge , Sahil Murtaza , Anthony Cortez , Homa Alemzadeh

In recent years, there has been substantial progress in using pretrained Language Models (LMs) on a range of tasks aimed at improving the understanding of biomedical texts. Nonetheless, existing biomedical LLMs show limited comprehension of…

Computation and Language · Computer Science 2025-09-10 Andrey Sakhovskiy , Elena Tutubalina

Biomedical queries often rely on a deep understanding of specialized knowledge such as gene regulatory mechanisms and pathological processes of diseases. They require detailed analysis of complex physiological processes and effective…

Computation and Language · Computer Science 2026-02-02 Congying Liu , Xingyuan Wei , Peipei Liu , Yiqing Shen , Yanxu Mao , Tiehan Cui

Healthcare systems continuously generate vast amounts of electronic health records (EHRs), commonly stored in the Fast Healthcare Interoperability Resources (FHIR) standard. Despite the wealth of information in these records, their…

Computation and Language · Computer Science 2025-01-24 Sara Kothari , Ayush Gupta

Since the inception of the Transformer architecture in 2017, Large Language Models (LLMs) such as GPT and BERT have evolved significantly, impacting various industries with their advanced capabilities in language understanding and…

Computation and Language · Computer Science 2024-05-30 Yining Huang , Keke Tang , Meilian Chen , Boyuan Wang

In response to the pressing need for advanced clinical problem-solving tools in healthcare, we introduce BooksMed, a novel framework based on a Large Language Model (LLM). BooksMed uniquely emulates human cognitive processes to deliver…

Retrieval augmented generation (RAG) has shown great power in improving Large Language Models (LLMs). However, most existing RAG-based LLMs are dedicated to retrieving single modality information, mainly text; while for many real-world…

Computation and Language · Computer Science 2025-06-09 Saptarshi Sengupta , Shuhua Yang , Paul Kwong Yu , Fali Wang , Suhang Wang