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Large Language Models (LLMs) have rapidly become important tools in Biomedical and Health Informatics (BHI), enabling new ways to analyze data, treat patients, and conduct research. This study aims to provide a comprehensive overview of LLM…

Digital Libraries · Computer Science 2024-07-30 Huizi Yu , Lizhou Fan , Lingyao Li , Jiayan Zhou , Zihui Ma , Lu Xian , Wenyue Hua , Sijia He , Mingyu Jin , Yongfeng Zhang , Ashvin Gandhi , Xin Ma

Medical text learning has recently emerged as a promising area to improve healthcare due to the wide adoption of electronic health record (EHR) systems. The complexity of the medical text such as diverse length, mixed text types, and full…

Computation and Language · Computer Science 2022-10-11 Yong He , Cheng Wang , Shun Zhang , Nan Li , Zhaorong Li , Zhenyu Zeng

Recent advances in large language models (LLMs) have shown impressive ability in biomedical question-answering, but have not been adequately investigated for more specific biomedical applications. This study investigates the performance of…

Computation and Language · Computer Science 2024-03-29 Shan Chen , Yingya Li , Sheng Lu , Hoang Van , Hugo JWL Aerts , Guergana K. Savova , Danielle S. Bitterman

Digital health tools have the potential to significantly improve the delivery of healthcare services. However, their adoption remains comparatively limited due, in part, to challenges surrounding usability and trust. Large Language Models…

Computation and Language · Computer Science 2024-03-01 Fergus Imrie , Paulius Rauba , Mihaela van der Schaar

Pre-consultation is a critical component of effective healthcare delivery. However, generating comprehensive pre-consultation questionnaires from complex, voluminous Electronic Medical Records (EMRs) is a challenging task. Direct Large…

Artificial Intelligence · Computer Science 2025-08-04 Ruiqing Ding , Qianfang Sun , Yongkang Leng , Hui Yin , Xiaojian Li

Retrieval-augmented Large Language Models (LLMs) have reshaped traditional query-answering systems, offering unparalleled user experiences. However, existing retrieval techniques often struggle to handle multi-modal query contexts. In this…

Databases · Computer Science 2024-07-08 Mengzhao Wang , Haotian Wu , Xiangyu Ke , Yunjun Gao , Xiaoliang Xu , Lu Chen

We evaluate four state-of-the-art instruction-tuned large language models (LLMs) -- ChatGPT, Flan-T5 UL2, Tk-Instruct, and Alpaca -- on a set of 13 real-world clinical and biomedical natural language processing (NLP) tasks in English, such…

Computation and Language · Computer Science 2024-06-11 Yanis Labrak , Mickael Rouvier , Richard Dufour

Question answering is a natural language understanding task that involves reasoning over both explicit context, and unstated relevant domain knowledge. Despite the high cost of training, large language models (LLMs) -- the backbone of most…

Computation and Language · Computer Science 2025-04-24 Laura Cabello , Carmen Martin-Turrero , Uchenna Akujuobi , Anders Søgaard , Carlos Bobed

This research paper investigates the application of Large Language Models (LLMs) in healthcare, specifically focusing on enhancing medical decision support through Retrieval-Augmented Generation (RAG) integrated with hospital-specific data…

Computation and Language · Computer Science 2025-05-07 Mohammad Shoaib Ansari , Mohd Sohail Ali Khan , Shubham Revankar , Aditya Varma , Anil S. Mokhade

Biomedical Named Entity Recognition (NER) is a fundamental task of Biomedical Natural Language Processing for extracting relevant information from biomedical texts, such as clinical records, scientific publications, and electronic health…

Computation and Language · Computer Science 2023-12-27 Fahime Shahrokh , Nasser Ghadiri , Rasoul Samani , Milad Moradi

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Clinical Question-Answering (CQA) industry systems are increasingly rely on Large Language Models (LLMs), yet their deployment is often guided by the assumption that domain-specific fine-tuning is essential. Although specialised medical…

Computation and Language · Computer Science 2026-01-21 Sushant Kumar Ray , Gautam Siddharth Kashyap , Sahil Tripathi , Nipun Joshi , Vijay Govindarajan , Rafiq Ali , Jiechao Gao , Usman Naseem

Recent years have witnessed a substantial increase in the use of deep learning to solve various natural language processing (NLP) problems. Early deep learning models were constrained by their sequential or unidirectional nature, such that…

Information Retrieval · Computer Science 2024-03-05 Jiajia Wang , Jimmy X. Huang , Xinhui Tu , Junmei Wang , Angela J. Huang , Md Tahmid Rahman Laskar , Amran Bhuiyan

ChatGPT has drawn considerable attention from both the general public and domain experts with its remarkable text generation capabilities. This has subsequently led to the emergence of diverse applications in the field of biomedicine and…

Medical question-answering (QA) is a critical task for evaluating how effectively large language models (LLMs) encode clinical knowledge and assessing their potential applications in medicine. Despite showing promise on multiple-choice…

Computation and Language · Computer Science 2025-03-06 Guangfu Guo , Kai Zhang , Bryan Hoo , Yujun Cai , Xiaoqian Lu , Nanyun Peng , Yiwei Wang

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

LLMs have demonstrated impressive performance in answering medical questions, such as achieving passing scores on medical licensing examinations. However, medical board exams or general clinical questions do not capture the complexity of…

Computation and Language · Computer Science 2026-02-19 Hanjie Chen , Zhouxiang Fang , Yash Singla , Mark Dredze

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Computation and Language · Computer Science 2024-06-07 Anand Subramanian , Viktor Schlegel , Abhinav Ramesh Kashyap , Thanh-Tung Nguyen , Vijay Prakash Dwivedi , Stefan Winkler

Motivated by the emerging demand in the financial industry for the automatic analysis of unstructured and structured data at scale, Question Answering (QA) systems can provide lucrative and competitive advantages to companies by…

Computation and Language · Computer Science 2025-05-05 Bithiah Yuan

Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation,…

Computation and Language · Computer Science 2024-12-31 Hanguang Xiao , Feizhong Zhou , Xingyue Liu , Tianqi Liu , Zhipeng Li , Xin Liu , Xiaoxuan Huang
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