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Alzheimer's disease (AD) is a neurodegenerative disorder marked by memory loss and cognitive decline, making early detection vital for timely intervention. However, early diagnosis is challenging due to the heterogeneous presentation of…

Neurons and Cognition · Quantitative Biology 2025-09-24 Ali Khazaee , Abdolreza Mohammadi , Ruairi O'Reilly

Early diagnosis of Alzheimer's disease (AD) remains a major challenge due to the subtle and temporally irregular progression of structural brain changes in the prodromal stages. Existing deep learning approaches require large longitudinal…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Maxx Richard Rahman , Mostafa Hammouda , Wolfgang Maass

Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Yifei Chen , Shenghao Zhu , Zhaojie Fang , Chang Liu , Binfeng Zou , Yuhe Wang , Shuo Chang , Fan Jia , Feiwei Qin , Jin Fan , Yong Peng , Changmiao Wang

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

This paper presents a Domain-Inspired Sharpness-Aware Minimization (DISAM) algorithm for optimization under domain shifts. It is motivated by the inconsistent convergence degree of SAM across different domains, which induces optimization…

Computer Vision and Pattern Recognition · Computer Science 2024-05-30 Ruipeng Zhang , Ziqing Fan , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Mixup is an efficient data augmentation approach that improves the generalization of neural networks by smoothing the decision boundary with mixed data. Recently, dynamic mixup methods have improved previous static policies effectively…

Machine Learning · Computer Science 2023-10-24 Zicheng Liu , Siyuan Li , Ge Wang , Cheng Tan , Lirong Wu , Stan Z. Li

Understanding the relationship between cognition and intrinsic brain activity through purely data-driven approaches remains a significant challenge in neuroscience. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a…

Machine Learning · Computer Science 2024-11-01 Yutong Gao , Vince D. Calhoun , Robyn L. Miller

Hyperspectral imagery collected from airborne or satellite sources inevitably suffers from spectral variability, making it difficult for spectral unmixing to accurately estimate abundance maps. The classical unmixing model, the linear…

Computer Vision and Pattern Recognition · Computer Science 2019-06-25 Danfeng Hong , Naoto Yokoya , Jocelyn Chanussot , Xiao Xiang Zhu

Deep learning (DL) models have shown significant potential in Alzheimer's Disease (AD) classification. However, understanding and interpreting these models remains challenging, which hinders the adoption of these models in clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-09-10 Thomas Yu Chow Tam , Litian Liang , Ke Chen , Haohan Wang , Wei Wu

Alzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage such that intervention can be applied before…

Machine Learning · Computer Science 2024-09-02 Yipei Wang , Bing He , Shannon Risacher , Andrew Saykin , Jingwen Yan , Xiaoqian Wang

Disease progression modeling provides a robust framework to identify long-term disease trajectories from short-term biomarker data. It is a valuable tool to gain a deeper understanding of diseases with a long disease trajectory, such as…

Clinical abnormality grounding for rare diseases is often hindered by data scarcity, making supervised fine-tuning impractical and single-pass inference highly unstable. We propose Dynamic Decision Learning (DDL), a framework that enables…

Computation and Language · Computer Science 2026-04-29 Jun Li , Mingxuan Liu , Jiazhen Pan , Che Liu , Wenjia Bai , Cosmin I. Bercea , Julia A. Schnabel

The domain shift between training and testing data presents a significant challenge for training generalizable deep learning models. As a consequence, the performance of models trained with the independent and identically distributed…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Aleksandr Matsun , Dana O. Mohamed , Sharon Chokuwa , Muhammad Ridzuan , Mohammad Yaqub

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing prevalence among the aging population, necessitating early and accurate diagnosis for effective disease management. In this study, we present a novel…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Romoke Grace Akindele , Samuel Adebayo , Paul Shekonya Kanda , Ming Yu

Accurate diagnosis and prognosis of Alzheimer's disease are crucial to develop new therapies and reduce the associated costs. Recently, with the advances of convolutional neural networks, methods have been proposed to automate these two…

Image and Video Processing · Electrical Eng. & Systems 2022-11-29 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

The automatic early diagnosis of prodromal stages of Alzheimer's disease is of great relevance for patient treatment to improve quality of life. We address this problem as a multi-modal classification task. Multi-modal data provides richer…

Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to…

Multi-domain fine-tuning of large language models requires improving performance on target domains while preserving performance on constrained domains, such as general knowledge, instruction following, or safety evaluations. Existing data…

Machine Learning · Computer Science 2026-05-12 Eleonora Gualdoni , Sonia Laguna , Louis Bethune , Joao Monteiro , Pierre Ablin , Marco Cuturi

Deep learning (DL) has been the primary approach used in various computer vision tasks due to its relevant results achieved on many tasks. However, on real-world scenarios with partially or no labeled data, DL methods are also prone to the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Lucas Fernando Alvarenga e Silva , Daniel Carlos Guimarães Pedronette , Fábio Augusto Faria , João Paulo Papa , Jurandy Almeida

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman