Early diagnosis of Alzheimer's disease (AD) remains a major challenge due to the subtle and temporally irregular progression of structural brain changes in the prodromal stages. Existing deep learning approaches require large longitudinal datasets and often fail to model the temporal continuity and modality irregularities inherent in real-world clinical data. To address these limitations, we propose the Diffusion-Guided Attention Network (DiGAN), which integrates latent diffusion modelling with an attention-guided convolutional network. The diffusion model synthesizes realistic longitudinal neuroimaging trajectories from limited training data, enriching temporal context and improving robustness to unevenly spaced visits. The attention-convolutional layer then captures discriminative structural-temporal patterns that distinguish cognitively normal subjects from those with mild cognitive impairment and subjective cognitive decline. Experiments on the ADNI dataset demonstrate that DiGAN outperforms existing state-of-the-art baselines, showing its potential for early-stage AD detection.
@article{arxiv.2602.03881,
title = {DiGAN: Diffusion-Guided Attention Network for Early Alzheimer's Disease Detection},
author = {Maxx Richard Rahman and Mostafa Hammouda and Wolfgang Maass},
journal= {arXiv preprint arXiv:2602.03881},
year = {2026}
}