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The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Mauricio Orbes-Arteaga , Thomas Varsavsky , Lauge Sorensen , Mads Nielsen , Akshay Pai , Sebastien Ourselin , Marc Modat , M Jorge Cardoso

Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in…

Machine Learning · Computer Science 2019-08-14 Vikram Venkatraghavan , Esther E. Bron , Wiro J. Niessen , Stefan Klein

This paper presents a general framework for obtaining interpretable multivariate discriminative models that allow efficient statistical inference for neuroimage analysis. The framework, termed generative discriminative machine (GDM),…

Applications · Statistics 2019-06-04 Erdem Varol , Aristeidis Sotiras , Ke Zeng , Christos Davatzikos

Unsupervised Domain Adaptive Object Detection (DAOD) could adapt a model trained on a source domain to an unlabeled target domain for object detection. Existing unsupervised DAOD methods usually perform feature alignments from the target to…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Jie Shao , Jiacheng Wu , Wenzhong Shen , Cheng Yang

Domain adaptation (DA) enables knowledge transfer from a labeled source domain to an unlabeled target domain by reducing the cross-domain distribution discrepancy. Most prior DA approaches leverage complicated and powerful deep neural…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Shuang Li , Jinming Zhang , Wenxuan Ma , Chi Harold Liu , Wei Li

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

Alzheimer's Disease (AD) is a prevalent neurodegenerative condition where early detection is vital. Handwriting, often affected early in AD, offers a non-invasive and cost-effective way to capture subtle motor changes. State-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Changqing Gong , Huafeng Qin , Mounîm A. El-Yacoubi

Recent advances on unsupervised domain adaptation (UDA) rely on adversarial learning to disentangle the explanatory and transferable features for domain adaptation. However, there are two issues with the existing methods. First, the…

Machine Learning · Computer Science 2020-07-20 Yuan Wu , Diana Inkpen , Ahmed El-Roby

Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data. However, conventional fusion approaches often rely on…

Machine Learning · Computer Science 2026-04-14 Farica Zhuang , Shu Yang , Dinara Aliyeva , Zixuan Wen , Duy Duong-Tran , Christos Davatzikos , Tianlong Chen , Song Wang , Li Shen

Alzheimer's disease (AD) is an incurable neurodegenerative condition leading to cognitive and functional deterioration. Given the lack of a cure, prompt and precise AD diagnosis is vital, a complex process dependent on multiple factors and…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Guangqian Yang , Kangrui Du , Zhihan Yang , Ye Du , Yongping Zheng , Shujun Wang

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Alzheimer's disease (AD) is a progressive neurodegenerative disease with high inter-patient variance in rate of cognitive decline. AD progression prediction aims to forecast patient cognitive decline and benefits from incorporating multiple…

Machine Learning · Computer Science 2025-09-17 Benjamin Burns , Yuan Xue , Douglas W. Scharre , Xia Ning

Deep learning models in medical imaging typically operate as parametric memory, diagnosing patients by recalling fixed knowledge learned during training. This contrasts sharply with clinical practice, where physicians employ analogical…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Lujia Zhong , Yihao Xia , Shuo Huang , Jianwei Zhang , Yonggang Shi

Magnetic resonance (MR) imaging, including cardiac MR, is prone to domain shift due to variations in imaging devices and acquisition protocols. This challenge limits the deployment of trained AI models in real-world scenarios, where…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xin Ci Wong , Duygu Sarikaya , Kieran Zucker , Marc De Kamps , Nishant Ravikumar

Dysarthric speech detection (DSD) systems aim to detect characteristics of the neuromotor disorder from speech. Such systems are particularly susceptible to domain mismatch where the training and testing data come from the source and target…

Audio and Speech Processing · Electrical Eng. & Systems 2021-07-26 Disong Wang , Liqun Deng , Yu Ting Yeung , Xiao Chen , Xunying Liu , Helen Meng

Alzheimer's disease (AD) is an irreversible brain disease that can dramatically reduce quality of life, most commonly manifesting in older adults and eventually leading to the need for full-time care. Early detection is fundamental to…

Computation and Language · Computer Science 2019-06-14 Flavio Di Palo , Natalie Parde

Multiple types or views of data (e.g. genetics, proteomics) measured on the same set of individuals are now popularly generated in many biomedical studies. A particular interest might be the detection of sample subgroups (e.g. subtypes of…

Methodology · Statistics 2025-05-09 Kaifeng Yang , Thierry Chekouo , Sandra E. Safo

Structural magnetic resonance imaging (MRI) studies have shown that Alzheimer's Disease (AD) induces both localised and widespread neural degenerative changes throughout the brain. However, the absence of segmentation that highlights brain…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Chen Zheng

Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects millions of people worldwide. Due to the heterogeneous nature of AD, its diagnosis and treatment pose critical challenges. Consequently, there is a growing…

Machine Learning · Computer Science 2024-10-08 Tianyi Wei , Shu Yang , Davoud Ataee Tarzanagh , Jingxuan Bao , Jia Xu , Patryk Orzechowski , Joost B. Wagenaar , Qi Long , Li Shen

Early diagnosis of Alzheimer's Disease (AD), particularly at the mild cognitive impairment stage, is essential for timely intervention. However, this process faces significant barriers, including reliance on subjective assessments and the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Changwei Wu , Yifei Chen , Yuxin Du , Jinying Zong , Jie Dong , Mingxuan Liu , Feiwei Qin , Yong Peng , Jin Fan , Changmiao Wang
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