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The field of medical diagnosis has undergone a significant transformation with the advent of large language models (LLMs), yet the challenges of interpretability within these models remain largely unaddressed. This study introduces…

Computation and Language · Computer Science 2024-09-17 Junying Chen , Chi Gui , Anningzhe Gao , Ke Ji , Xidong Wang , Xiang Wan , Benyou Wang

Medical vision-language pretraining (VLP) that leverages naturally-paired medical image-report data is crucial for medical image analysis. However, existing methods struggle to accurately characterize associations between images and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Xinjie Liang , Xiangyu Li , Fanding Li , Jie Jiang , Qing Dong , Wei Wang , Kuanquan Wang , Suyu Dong , Gongning Luo , Shuo Li

Background: Large language models (LLMs) such as OpenAI's GPT-4 or Google's PaLM 2 are proposed as viable diagnostic support tools or even spoken of as replacements for "curbside consults". However, even LLMs specifically trained on medical…

Artificial Intelligence · Computer Science 2024-10-21 Gioele Barabucci , Victor Shia , Eugene Chu , Benjamin Harack , Nathan Fu

Pre-trained on extensive text and image corpora, current Multi-Modal Large Language Models (MLLM) have shown strong capabilities in general visual reasoning tasks. However, their performance is still lacking in physical domains that require…

Artificial Intelligence · Computer Science 2025-07-04 Erle Zhu , Yadi Liu , Zhe Zhang , Xujun Li , Jin Zhou , Xinjie Yu , Minlie Huang , Hongning Wang

Multimodal large language models (MLLMs) have emerged as powerful tools for computational pathology, offering unprecedented opportunities to integrate pathological images with language context for comprehensive diagnostic analysis. These…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Zhe Xu , Ziyi Liu , Junlin Hou , Jiabo Ma , Cheng Jin , Yihui Wang , Zhixuan Chen , Zhengyu Zhang , Fuxiang Huang , Zhengrui Guo , Fengtao Zhou , Yingxue Xu , Xi Wang , Ronald Cheong Kin Chan , Li Liang , Hao Chen

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Jing Zhang , Xiaowei Yu , Yanjun Lyu , Lu Zhang , Tong Chen , Chao Cao , Yan Zhuang , Minheng Chen , Tianming Liu , Dajiang Zhu

Large language models (LLMs) have demonstrated promising performance in generating diagnostic conclusions from imaging findings, thereby supporting radiology reporting, trainee education, and quality control. However, systematic guidance on…

Artificial Intelligence · Computer Science 2026-05-26 Qiuli Wang , Xinhuang Sun , Yonglin Chen , Jie Cheng , Yongxu Liu , Xingpeng Zhang , Xiaoming Li , Wei Chen

Acute Lymphoblastic Leukemia (ALL) is one of the most common types of childhood blood cancer. The quick start of the treatment process is critical to saving the patient's life, and for this reason, early diagnosis of this disease is…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Amirhossein Askari Farsangi , Ali Sharifi-Zarchi , Mohammad Hossein Rohban

Multi-modal ophthalmic image classification plays a key role in diagnosing eye diseases, as it integrates information from different sources to complement their respective performances. However, recent improvements have mainly focused on…

Image and Video Processing · Electrical Eng. & Systems 2024-05-29 Ke Zou , Tian Lin , Zongbo Han , Meng Wang , Xuedong Yuan , Haoyu Chen , Changqing Zhang , Xiaojing Shen , Huazhu Fu

Medical vision-and-language models (MVLMs) have attracted substantial interest due to their capability to offer a natural language interface for interpreting complex medical data. Their applications are versatile and have the potential to…

Computer Vision and Pattern Recognition · Computer Science 2024-11-20 Qi Chen , Ruoshan Zhao , Sinuo Wang , Vu Minh Hieu Phan , Anton van den Hengel , Johan Verjans , Zhibin Liao , Minh-Son To , Yong Xia , Jian Chen , Yutong Xie , Qi Wu

Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to…

Computation and Language · Computer Science 2026-04-28 Yimin Deng , Zhenxi Lin , Yejing Wang , Guoshuai Zhao , Pengyue Jia , Zichuan Fu , Derong Xu , Yefeng Zheng , Xiangyu Zhao , Li Zhu , Xian Wu , Xueming Qian

Pathological diagnosis is vital for determining disease characteristics, guiding treatment, and assessing prognosis, relying heavily on detailed, multi-scale analysis of high-resolution whole slide images (WSI). However, existing large…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shengxuming Zhang , Weihan Li , Tianhong Gao , Jiacong Hu , Haoming Luo , Xiuming Zhang , Jing Zhang , Mingli Song , Zunlei Feng

Chronic Obstructive Pulmonary Disease (COPD), a major chronic respiratory disease with persistent airflow limitation, is a leading global cause of disability and mortality. Respiratory spirogram time series, routinely collected during…

Artificial Intelligence · Computer Science 2026-03-03 Shuhao Mei , Yongchao Long , Xiaoyu Xiao , Shan Cao , Xiaobo Han , Shijia Geng , Jinbo Sun , Yuxi Zhou , Shenda Hong

The integration of deep learning-based glaucoma detection with large language models (LLMs) presents an automated strategy to mitigate ophthalmologist shortages and improve clinical reporting efficiency. However, applying general LLMs to…

Multiagent Systems · Computer Science 2025-12-18 Philip R. Liu , Sparsh Bansal , Jimmy Dinh , Aditya Pawar , Ramani Satishkumar , Shail Desai , Neeraj Gupta , Xin Wang , Shu Hu

Large Language Model (LLM)-based systems present new opportunities for autonomous health monitoring in sensor-rich industrial environments. This study explores the potential of LLMs to detect and classify faults directly from sensor data,…

Artificial Intelligence · Computer Science 2025-09-30 Xian Yeow Lee , Lasitha Vidyaratne , Ahmed Farahat , Chetan Gupta

Large language models (LLMs) are gaining increasing interests to improve clinical efficiency for medical diagnosis, owing to their unprecedented performance in modelling natural language. Ensuring the safe and reliable clinical…

Computation and Language · Computer Science 2024-03-26 Lei Liu , Xiaoyan Yang , Fangzhou Li , Chenfei Chi , Yue Shen , Shiwei Lyu Ming Zhang , Xiaowei Ma , Xiangguo Lyu , Liya Ma , Zhiqiang Zhang , Wei Xue , Yiran Huang , Jinjie Gu

Multispectral pedestrian detection is a crucial component in various critical applications. However, a significant challenge arises due to the misalignment between these modalities, particularly under real-world conditions where data often…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Taeheon Kim , Sangyun Chung , Youngjoon Yu , Yong Man Ro

In recent years, Multimodal Large Language Models (MLLM) have achieved notable advancements, demonstrating the feasibility of developing an intelligent biomedical assistant. However, current biomedical MLLMs predominantly focus on…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Xiaoshuang Huang , Lingdong Shen , Jia Liu , Fangxin Shang , Hongxiang Li , Haifeng Huang , Yehui Yang

Accurate diagnosis of ophthalmic diseases relies heavily on the interpretation of multimodal ophthalmic images, a process often time-consuming and expertise-dependent. Visual Question Answering (VQA) presents a potential interdisciplinary…

Image and Video Processing · Electrical Eng. & Systems 2024-10-23 Xiaolan Chen , Ruoyu Chen , Pusheng Xu , Weiyi Zhang , Xianwen Shang , Mingguang He , Danli Shi

Rapid integration of large language models (LLMs) in health care is sparking global discussion about their potential to revolutionize health care quality and accessibility. At a time when improving health care quality and access remains a…

Computers and Society · Computer Science 2025-04-01 Troy Zada , Natalie Tam , Francois Barnard , Marlize Van Sittert , Venkat Bhat , Sirisha Rambhatla