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We present a dual color laser scanning endomicroscope capable of fluorescence lifetime endomicroscopy at one frame per second (FPS). The scanning system uses a coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is…

Spectral imaging in the mid-infrared (MIR) range provides simultaneous morphological and chemical information of a wide variety of samples. However, current MIR technologies struggle to produce high-definition images over a broad spectral…

Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…

In the past two decades a range of fluorescence cell microscopy techniques have been developed which can achieve ~10 nm spatial resolution, i.e. substantially beating the usual limits set by optical diffraction. However, these methods rely…

We present gapless, high-resolution absorption and dispersion spectra obtained with quantum cascade laser frequency combs covering 55 cm$^{-1}$. Using phase-sensitive dual comb design, the comb lines are gradually swept over 10 GHz,…

Dual-comb spectroscopy has emerged as an indispensable analytical technique in applications that require high resolution and broadband coverage within short acquisition times. Its experimental realization, however, remains hampered by…

Instrumentation and Detectors · Physics 2019-12-02 Łukasz A. Sterczewski , Aleksandra Przewłoka , Wawrzyniec Kaszub , Jarosław Sotor

Broadband dual-comb spectroscopy has attracted increasing interests due to its unique advantages in high spectral resolution, fast detection, and so on. Although the dual-comb technique is relatively mature in the infrared wavelengths, it…

Four-wave-mixing-based quantum cascade laser frequency combs (QCL-FC) are a powerful photonic tool, driving a recent revolution in major molecular fingerprint regions, i.e. mid- and far-infrared domains. Their compact and frequency-agile…

Mid-infrared spectroscopy is often used to identify material. Thousands of spectral points are measured in a time-consuming process using expensive table-top instrument. However, material identification is a sparse problem, which in theory…

Instrumentation and Detectors · Physics 2022-12-27 Yurui Qu , Qingyi Zhou , Jin Xiang , Zongfu Yu

Numerous modern technologies are reliant on the low-phase noise and exquisite timing stability of microwave signals. Substantial progress has been made in the field of microwave photonics, whereby low noise microwave signals are generated…

Dual-frequency comb spectroscopy has emerged as a disruptive technique for measuring wide-spanning spectra with high resolution, yielding a particularly powerful technique for sensitive multi-component gas analysis. We present a…

While being invented for precision measurement of single atomic transitions, frequency combs have also become a versatile tool for broadband spectroscopy in the last years. In this paper we present a novel and simple approach for broadband…

Two-photon excitation spectroscopy with broad spectral span is demonstrated at Doppler-limited resolution. We describe first Fourier transform two-photon spectroscopy of an atomic sample with two mode-locked laser oscillators in a dual-comb…

Chip-scale optical frequency combs can provide broadband spectroscopy for diagnosing complex organic molecules. They are also promising as miniaturized laser spectrometers in applications ranging from atmospheric chemistry to geological…

Nonlinear optical microscopy allows rapid high-resolution microscopy with image contrast generated from intrinsic properties of the sample. Established modalities such as multiphoton excited fluorescence and second/third-harmonic generation…

A train of periodic optical pulses gives an optical frequency "comb" that acts as a precise ruler for light measurement due to its equally spaced frequencies. Today, such pulses last millionths of a billionth of a second (Femtoseconds/fs)…

Optics · Physics 2026-05-22 Tushar Malica

Outlined here is a technique for sub-wavelength infrared surface imaging performed using a phase matched optical parametric oscillator laser and an atomic force microscope as the detection mechanism. The technique uses a novel surface…

The broad and equidistant spectrum of frequency combs has had a profound impact on spectroscopic studies. Particularly, experiments involving the coupling of frequency combs to cavities have already enabled unprecedented broadband and…

Optics · Physics 2024-12-10 Andrei Diakonov , Konstantin Khrizman , Eliran Zano , Liron Stern

The progress of semiconductor electronics toward ever-smaller length scales and associated higher power densities brings a need for new high-resolution thermal microscopy techniques. Traditional thermal microscopy is performed by detecting…

Materials Science · Physics 2015-05-13 Todd Brintlinger , Yi Qi , Kamal H. Baloch , David Goldhaber-Gordon , John Cumings

Dual-comb spectroscopy (DCS) utilizes a pair of broadband mutually coherent laser frequency combs to enable high-resolution, high-accuracy spectroscopic measurements with atomic-clock-level frequency referencing, and rapid, multiplexed…

Optics · Physics 2025-10-01 D. Konnov , A. Muraviev , K. L. Vodopyanov