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Knee osteoarthritis frequently exhibits discordance between structural damage observed in imaging and patient-reported symptoms such as pain. This mismatch complicates clinical interpretation and patient stratification and remains…

Machine Learning · Computer Science 2026-04-21 Pegah Ahadian , Mingrui Yang , Sixu Chen , Xiaojuan Li , Qiang Guan

Musculoskeletal and neurological disorders are the most common causes of walking problems among older people, and they often lead to diminished quality of life. Analyzing walking motion data manually requires trained professionals and the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Manli Zhu , Qianhui Men , Edmond S. L. Ho , Howard Leung , Hubert P. H. Shum

Clinical assessments for neuromuscular disorders, such as Spinal Muscular Atrophy (SMA) and Duchenne Muscular Dystrophy (DMD), continue to rely on subjective measures to monitor treatment response and disease progression. We introduce a…

Robotic-assisted orthopaedic surgeries demand accurate, automated leg manipulation for improved spatial accuracy to reduce iatrogenic damage. In this study, we propose novel rigid body designs and an optical tracking volume setup for…

Robotics · Computer Science 2019-09-09 Mario Strydom , Artur Banach , Liao Wu , Ross Crawford , Jonathan Roberts , Anjali Jaiprakash

Background: Minute-level accelerometer data capture rich diurnal physical activity (PA) patterns, but conventional summary metrics obscures clinically meaningful changes accumulated across a day. Building on Riemannian framework, we…

Rheumatoid arthritis (RA) has an intricate etiology that includes environmental factors as well as genetics. Organophosphate esters (OPEs) are frequently used as chemical additives in many personal care products and household items.…

Quantitative Methods · Quantitative Biology 2024-09-04 Sneha Singh , Elsa Pirouz , Amir Shahmoradi

Background: Accumulation of abnormal contact stress is a primary biomechanical driver of acute meniscal tears and chronic osteoarthritis. While Finite Element Analysis (FEA) provides the necessary fidelity to quantify these injury-inducing…

Quantitative Methods · Quantitative Biology 2025-12-16 Zhengye Pan , Jianwei Zuo , Jiajia Luo

Osteoporosis silently erodes skeletal integrity worldwide; however, early detection through imaging can prevent most fragility fractures. Artificial intelligence (AI) methods now mine routine Dual-energy X-ray Absorptiometry (DXA), X-ray,…

Image and Video Processing · Electrical Eng. & Systems 2025-10-02 Abdul Rahman , Bumshik Lee

In many real-world applications, functional data exhibit considerable variability in both amplitude and phase. This is especially true in biomechanical data such as the knee flexion angle dataset motivating our work, where timing…

Methodology · Statistics 2025-06-18 Jacopo Gardella , Raffaele Argiento , Alessandro Casa , Alessia Pini

Background. Osteoarthritis affects about 528 million people worldwide, causing pain and stiffness in the joints. Arthroplasty is commonly performed to treat joint osteoarthritis, reducing pain and improving mobility. Nevertheless, a…

Precise tracking of the jaw kinematics is crucial for diagnosing various musculoskeletal and neuromuscular diseases affecting the masticatory system and for advancing rehabilitative devices such as jaw exoskeletons, a hardly explored…

Human-Computer Interaction · Computer Science 2026-01-21 Paul-Otto Müller , Sven Suppelt , Mario Kupnik , Oskar von Stryk

Current studies on human locomotion focus mainly on solid ground walking conditions. In this paper, we present a biomechanic comparison of human walking locomotion on solid ground and sand. A novel dataset containing 3-dimensional motion…

Robotics · Computer Science 2024-07-02 Chunchu Zhu , Xunjie Chen , Jingang Yi

Simulation studies like finite element (FE) modeling provide insight into knee joint mechanics without patient experimentation. Generic FE models represent biomechanical behavior of the tissue by overlooking variations in geometry, loading,…

Computer Vision and Pattern Recognition · Computer Science 2023-12-04 Reza Kakavand , Mehrdad Palizi , Peyman Tahghighi , Reza Ahmadi , Neha Gianchandani , Samer Adeeb , Roberto Souza , W. Brent Edwards , Amin Komeili

High-dimensional data with hundreds of thousands of observations are becoming commonplace in many disciplines. The analysis of such data poses many computational challenges, especially when the observations are correlated over time and/or…

Computation · Statistics 2011-08-05 Sylvie Tchumtchoua , David B. Dunson , Jeffrey S. Morris

We are motivated by a study that seeks to better understand the dynamic relationship between muscle activation and paw position during locomotion. For each gait cycle in this experiment, activation in the biceps and triceps is measured…

Methodology · Statistics 2024-07-01 Julia Wrobel , Britton Sauerbrei , Erik A. Kirk , Jian-Zhong Guo , Adam Hantman , Jeff Goldsmith

Simulation of assistive devices on pathological gait through musculoskeletal models offers the potential and advantages of estimating the effect of the device in several biomechanical variables and the device characteristics ahead of…

Medical Physics · Physics 2024-06-11 Galindo-Leon Sergio , Eriks-Hoogland Inge , Suzuki Kenji , Paez-Granados Diego

State-of-the-art automated segmentation algorithms are not 100\% accurate especially when segmenting difficult to interpret datasets like those with severe osteoarthritis (OA). We present a novel interactive method called just-enough…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Satyananda Kashyap , Honghai Zhang , Milan Sonka

Limited DXA access hinders osteoporosis screening. This proof-of-concept study proposes using widely available knee X-rays for opportunistic Bone Mineral Density (BMD) estimation via deep learning, emphasizing robust uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Long Hui , Wai Lok Yeung

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage…

Objective assessment of Magnetic Resonance Imaging (MRI) scans of osteoarthritis (OA) can address the limitation of the current OA assessment. Segmentation of bone, cartilage, and joint fluid is necessary for the OA objective assessment.…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Banafshe Felfeliyan , Abhilash Hareendranathan , Gregor Kuntze , Jacob L. Jaremko , Janet L. Ronsky
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