Related papers: Specific Nucleic Acid Detection Using a Nanopartic…
DNA-driven self-assembly enables precise positioning of the colloidal nanoparticles owing to specific Watson-Crick interactions. Another important feature of this self-assembly method is its reversibility by controlling the temperature of…
Plasmonic nanopores combine nanofluidic confinement with electromagnetic field enhancement, enabling optical interrogation of single molecules in sub-wavelength volumes. Yet, direct optical readout within these metallic geometries has…
Unsupervised anomaly detection is a promising technique for identifying unusual patterns in data without the need for labeled training examples. This approach is particularly valuable for early case detection in epidemic management,…
We demonstrate the stimulated Raman near-field microscopy of few molecules, measured only using near-field optical forces thereby eliminating the need for far-field optical detection. The molecules were excited in the near-field without…
In the framework of rare event searches, the identification of radioactive contaminants in ultra-pure samples is a challenging task, because the signal is often at the same level of the instrumental background. This is a rather common…
Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic interactions. Here, fused multi-modal electron microscopy offers high signal-to-noise ratio (SNR)…
Sequence coverage in MS analysis of protein digestion-derived peptides is a key issue for detailed characterization of proteins or identification at low quantities. In gel-based proteomics studies, the sequence coverage greatly depends on…
Non-Hermitian singularities known as exceptional-points (EPs) have been shown to exhibit increased sensitivities but the observation of EPs has so far been limited to wavelength scaled systems subject to diffraction limit. We propose a…
Anomaly synthesis strategies can effectively enhance unsupervised anomaly detection. However, existing strategies have limitations in the coverage and controllability of anomaly synthesis, particularly for weak defects that are very similar…
In this work the synthesis and characterization of novel gold-nanodiamond nanoparticles was performed. The synthesis was based on the reduction of gold onto the different types of nanodiamond (annealed or annealed and oxidized, 50 or 230…
With the growing interest in graphene field-effect transistors (GFETs) for biosensing applications, there is a strong demand for strategies enabling flexible and multiplexed biofunctionalization, as well as highly parallel, real-time…
Single-molecule detection with chemical specificity is a powerful and much desired tool for biology, chemistry, physics, and sensing technologies. Surface-enhanced spectroscopies enable single molecule studies, yet reliable substrates of…
Interferometric-based microscopies stand as powerful label-free approaches for monitoring and characterising chemical reactions and heterogeneous nanoparticle systems in real time with single particle sensitivity. Nevertheless, coherent…
While studying nucleic acids to reveal the weak interactions responsible for their three-dimensional structure and for their interactions with drugs, we also contributed to the field of biomolecular mass spectrometry, both in terms of…
Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size (~3-4 nm; 13 kDa) and favorable biophysical properties make them attractive…
Optical nanoantennas are a novel tool to investigate previously unattainable dimensions in the nanocosmos. Just like their radio-frequency equivalents, nanoantennas enhance the light-matter interaction in their feed gap. Antenna enhancement…
Optoplasmonic methods capable of single protein detection so far rely on analyte immobilization in order to facilitate detection [1-6]. These detection schemes, even if they facilitate transient single-molecule detection [7,8] via…
The absorptance of p-polarized light in superconducting-nanowire single-photon detectors (SNSPDs) was improved by integrating (1) ~quarter-wavelength nano-optical cavity closed by a gold reflector (OC-SNSPD), (2) nano-cavity-array closed by…
The combination of nanodiamonds with plasmonic metal particles is being explored for synergic effects that can enhance biosensing and antibacterial treatments, energy harvesting, photocatalysis, and quantum centres. Here we systematically…
A molecular and cellular understanding of how SARS-CoV-2 variably infects and causes severe COVID-19 remains a bottleneck in developing interventions to end the pandemic. We sought to use deep learning to study the biology of SARS-CoV-2…