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We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use…

Cell Behavior · Quantitative Biology 2023-03-16 Katiana Kontolati , Constantinos Siettos

In many stochastic service systems, decision-makers find themselves making a sequence of decisions, with the number of decisions being unpredictable. To enhance these decisions, it is crucial to uncover the causal impact these decisions…

Methodology · Statistics 2023-07-18 Juan C. David Gomez , Amy L. Cochran , Gabriel Zayas-Caban

This paper is concerned with the analysis of a class of impacting systems of relevance in applications: cam-follower systems. We show that these systems, which can be modelled as discontinuously forced impact oscillators, can exhibit…

Mathematical Physics · Physics 2007-11-08 Gustavo Osorio , Mario di Bernardo , Stefania Santini

We study the versatile performance of networks of coupled circuits. Each of these circuits is composed of a positive and a negative feedback loop in a motif that is frequently found in genetic and neural networks. When two of these circuits…

Adaptation and Self-Organizing Systems · Physics 2015-06-22 Darka Labavić , Hildegard Meyer-Ortmanns

We study homoclinic bifurcations in an interval map associated with a saddle-focus of (2, 1)-type in $\mathbb{Z}_2$-symmetric systems. Our study of this map reveals the homoclinic structure of the saddle-focus, with a bifurcation unfolding…

Dynamical Systems · Mathematics 2023-07-28 Carter Hinsley , James Scully , Andrey L. Shilnikov

Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…

Analysis of PDEs · Mathematics 2014-04-03 Mark Chaplain , Mariya Ptashnyk , Marc Sturrock

This work concerns a many-body deterministic model that displays life-like properties as emergence, complexity, self-organization, spontaneous compartmentalization, and self-regulation. The model portraits the dynamics of an ensemble of…

Adaptation and Self-Organizing Systems · Physics 2023-07-11 Alessandro Scirè , Valerio Annovazzi-Lodi

We numerically study the dynamics of run-and-tumble particles confined in two chambers connected by thin channels. Two dominant dynamical behaviors emerge: (i) an oscillatory pumping state, in which particles periodically fill the two…

Soft Condensed Matter · Physics 2015-11-04 M. Paoluzzi , R. Di Leonardo , L. Angelani

We have applied the Melnikov criterion to examine a global homoclinic bifurcation and transition to chaos in a case of the Duffing system with nonlinear fractional damping and external excitation. Using perturbation methods we have found a…

Chaotic Dynamics · Physics 2016-09-08 Marek Borowiec , Grzegorz Litak , Arkadiusz Syta

Microbes are everywhere, including in and on our bodies, and have been shown to play key roles in a variety of prevalent human diseases. Consequently, there has been intense interest in the design of bacteriotherapies or "bugs as drugs,"…

Machine Learning · Statistics 2020-04-13 Travis E. Gibson , Georg K. Gerber

Complex dynamical systems may exhibit multiple steady states, including time-periodic limit cycles, where the final trajectory depends on initial conditions. With tuning of parameters, limit cycles can proliferate or merge at an exceptional…

Statistical Mechanics · Physics 2024-12-03 Sergei Shmakov , Peter B. Littlewood

The attractors of a dynamical system govern its typical long-term behaviour. The presence of many attractors is significant as it means the behaviour is heavily dependent on the initial conditions. To understand how large numbers of…

Dynamical Systems · Mathematics 2022-06-20 Sishu Shankar Muni

Antibiotic-resistant bacteria has posed a grave threat to public health by causing a number of nosocomial infections in hospitals. Mathematical models have been used to study the transmission of antibiotic-resistant bacteria within a…

Populations and Evolution · Quantitative Biology 2016-10-06 Xiuli Cen , Zhilan Feng , Yiqiang Zheng , Yulin Zhao

We propose a system of differential equations modeling the competition between two obligate mutualistic species for a single nutrient in a chemostat. Each species promotes the growth of the other, and growth occurs only in the presence of…

Dynamical Systems · Mathematics 2026-03-12 Tahani Mtar , Radhouane Fekih-Salem

In living cells, chemical reactions form a complex network. Complicated dynamics arising from such networks are the origins of biological functions. We propose a novel mathematical method to analyze bifurcation behaviors of a reaction…

Molecular Networks · Quantitative Biology 2018-08-08 Takashi Okada , Je-Chiang Tsai , Atsushi Mochizuki

This research investigates the coupled dynamics of behavior and infectious disease using a mathematical model. We integrate a two-state q-voter opinion process with SIS-type infection dynamics, where transmission rates are influenced by the…

Physics and Society · Physics 2025-12-13 Thomas Goetz , Tyll Krueger , Karol Niedzielewski , Jan Schneider , Barbara Pabjan

Dynamical systems are used to model a variety of phenomena in which the bifurcation structure is a fundamental characteristic. Here we propose a statistical machine-learning approach to derive lowdimensional models that automatically…

Quantitative Methods · Quantitative Biology 2015-06-11 Yohei Kondo , Kunihiko Kaneko , Shuji Ishihara

Experimental observations of an almost symmetric electronic circuit show complicated sequences of bifurcations. These results are discussed in the light of a theory of imperfect global bifurcations. It is shown that much of the dynamics…

Chaotic Dynamics · Physics 2009-11-07 Paul Glendinning , Jan Abshagen , Tom Mullin

This paper investigates the different behaviors of the process equation and parameters of their occurrences. The process equation is a multistable one dimensional map with nonlinear feedback and can show various behaviors such as period…

We investigate the bifurcation structure of equilibria in a class of non-autonomous ordinary differential equations governed by a season length parameter, $\tau$, which determines the alternation between growth and decline dynamics. This…

Dynamical Systems · Mathematics 2025-07-09 Gonzalo Galiano , Julián Velasco