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Early detection of Parkinson's disease (PD) is important which can enable early initiation of therapeutic interventions and management strategies. However, methods for early detection still remain an unmet clinical need in PD. In this…

Applications · Statistics 2018-10-04 R Prashanth , Sumantra Dutta Roy

MRI, a widespread non-invasive medical imaging modality, is highly sensitive to patient motion. Despite many attempts over the years, motion correction remains a difficult problem and there is no general method applicable to all situations.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Oscar Dabrowski , Jean-Luc Falcone , Antoine Klauser , Julien Songeon , Michel Kocher , Bastien Chopard , François Lazeyras , Sébastien Courvoisier

Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system characterized by motor and non-motor symptoms. As the disease progresses, patients alternate periods in which motor symptoms are mitigated due to…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-26 Anna Pompili , Rubén Solera-Ureña , Alberto Abad , Rita Cardoso , Isabel Guimarães , Margherita Fabbri , Isabel P. Martins , Joaquim Ferreira

In this paper, we introduce a novel approach for diagnosis of Parkinson's Disease (PD) based on deep Echo State Networks (ESNs). The identification of PD is performed by analyzing the whole time-series collected from a tablet device during…

Machine Learning · Computer Science 2018-02-20 Claudio Gallicchio , Alessio Micheli , Luca Pedrelli

Parkinson's disease (PD) is a chronic neurodegenerative disease. Early diagnosis is essential to mitigate the progressive deterioration of patients' quality of life. The most characteristic motor symptoms are very mild in the early stages,…

Machine Learning · Computer Science 2026-01-27 Beatriz Pérez-Sánchez , Noelia Sánchez-Maroño , Miguel A. Díaz-Freire

Parkinson's disease is a progressive neurodegenerative disorder affecting motor and non-motor functions, with speech impairments among its earliest symptoms. Speech impairments offer a valuable diagnostic opportunity, with machine learning…

Machine Learning · Computer Science 2025-04-25 Lorenzo Simone , Mauro Giuseppe Camporeale , Vito Marco Rubino , Vincenzo Gervasi , Giovanni Dimauro

In recent years, deep learning methods have achieved great success in various fields due to their strong performance in practical applications. In this paper, we present a light-weight neural network for Parkinson's disease diagnostics, in…

Parkinson's disease (PD) is a slowly progressing neurodegenerative disease with early manifestation of motor signs. Recently, there has been a growing interest in developing automatic tools that can assess motor function in PD patients.…

Information Retrieval · Computer Science 2018-05-04 Liron Allerhand , Brit Youngmann , Elad Yom-Tov , David Arkadir

People with Parkinson's Disease (PD) can slow the progression of their symptoms with physical therapy. However, clinicians lack insight into patients' motor function during daily life, preventing them from tailoring treatment protocols to…

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder where motor dysfunction gradually increases as the disease progress. In addition to administering dopaminergic PD-specific drugs, attending neurologists strongly…

Computers and Society · Computer Science 2015-11-10 Ioannis Pachoulakis , Nikolaos Papadopoulos , Cleanthe Spanaki

Accurate and interpretable gait analysis plays a crucial role in the early detection of Parkinsons disease (PD),yet most existing approaches remain limited by single-modality inputs, low robustness, and a lack of clinical transparency. This…

Computer Vision and Pattern Recognition · Computer Science 2025-12-05 Manar Alnaasan , Md Selim Sarowar , Sungho Kim

Parkinson's Disease (PD) is a devastating neurodegenerative disorder that affects millions of people around the globe. Many researchers are continuously working to understand PD and develop treatments to improve the condition of PD…

Applications · Statistics 2025-12-16 Malinda Iluppangama , Dilmi Abeywardana , Chris Tsokos

Purpose: To develop a pipeline for motion artifact correction in mGRE and quantitative susceptibility mapping (QSM). Methods: Deep learning is integrated with autofocus to improve motion artifact suppression, which is applied QSM of…

Signal Processing · Electrical Eng. & Systems 2024-05-28 Chao Li , Jinwei Zhang , Hang Zhang , Jiahao Li , Pascal Spincemaille , Thanh D. Nguyen , Yi Wang

Deep brain stimulation (DBS) is an established intervention for Parkinson's disease (PD), but conventional open-loop systems lack adaptability, are energy-inefficient due to continuous stimulation, and provide limited personalization to…

Machine Learning · Computer Science 2025-07-10 Harsh Ravivarapu , Gaurav Bagwe , Xiaoyong Yuan , Chunxiu Yu , Lan Zhang

Parkinson's disease (PD) severity diagnosis is crucial for early detecting potential patients and adopting tailored interventions. Diagnosing PD based on facial expression is grounded in PD patients' "masked face" symptom and gains growing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yintao Zhou , Wei Huang , Zhengyu Li , Jing Huang , Meng Pang

Objective: To test automated in vivo estimation of active and passive skeletal muscle states using ultrasonic imaging. Background: Current technology (electromyography, dynamometry, shear wave imaging) provides no general, non-invasive…

Image and Video Processing · Electrical Eng. & Systems 2019-07-04 Ryan J. Cunningham , Ian D. Loram

Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and…

Quantitative Methods · Quantitative Biology 2019-11-11 Devin Taylor , Simeon Spasov , Pietro Liò

Parkinson's disease (PD) is a common and complex neurodegenerative disorder with 5 stages in the Hoehn and Yahr scaling. Given the heterogeneity of PD, it is challenging to classify early stages 1 and 2 and detect brain function…

Neurons and Cognition · Quantitative Biology 2022-07-22 Xueqi Guo , Sule Tinaz , Nicha C. Dvornek

The detection of human sleep stages is widely used in the diagnosis and intervention of neurological and psychiatric diseases. Some patients with deep brain stimulator implanted could have their neural activities recorded from the deep…

Machine Learning · Computer Science 2023-02-08 Chen Gong , Yue Chen , Yanan Sui , Luming Li