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While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

Randomized experiments play a major role in data-driven decision making across many different fields and disciplines. In medicine, for example, randomized controlled trials (RCTs) are the backbone of clinical trial methodology for testing…

Applications · Statistics 2016-08-30 Andrew W. Correia

Clinical trials are conducted to test the effectiveness and safety of potential drugs in humans for regulatory approval. Machine learning (ML) has recently emerged as a new tool to assist in clinical trials. Despite this progress, there…

Artificial Intelligence · Computer Science 2023-10-06 Zifeng Wang , Brandon Theodorou , Tianfan Fu , Cao Xiao , Jimeng Sun

With the advent of sophisticated machine learning (ML) techniques and the promising results they yield, especially in medical applications, where they have been investigated for different tasks to enhance the decision-making process. Since…

In this study, we investigate the feasibility of using a human-centered artificial intelligence (AI) chat platform where medical specialists collaboratively assess complex cases. As the target population for this platform, we focus on…

Human-Computer Interaction · Computer Science 2025-03-24 Shinnosuke Sawano , Satoshi Kodera

The rapid growth of scientific software has created practical barriers for bioinformatics research. Although powerful statistical, artificial intelligence (AI)-based methods are now widely available, their effective use is often hindered by…

Software Engineering · Computer Science 2026-04-24 Simon Süwer , Zoe Chervontseva , Kester Bagemihl , Jan Baumbach , Olga Tsoy , Andreas Maier

Recent technological advances in healthcare have led to unprecedented growth in patient data quantity and diversity. While artificial intelligence (AI) models have shown promising results in analyzing individual data modalities, there is…

Artificial Intelligence · Computer Science 2024-11-07 Daan Schouten , Giulia Nicoletti , Bas Dille , Catherine Chia , Pierpaolo Vendittelli , Megan Schuurmans , Geert Litjens , Nadieh Khalili

Continuous Medical Education (CME) plays a vital role in physicians' ongoing professional development. Beyond immediate diagnoses, physicians utilize multimodal diagnostic data for retrospective learning, engaging in self-directed analysis…

Human-Computer Interaction · Computer Science 2024-11-26 Yuansong Xu , Jiahe Dong , Yijie Fan , Yuheng Shao , Chang Jiang , Lixia Jin , Yuanwu Cao , Quan Li

Background: Identifying new indications for approved drugs is a complex and time-consuming process that requires extensive knowledge of pharmacology, clinical data, and advanced computational methods. Recently, deep learning (DL) methods…

Machine Learning · Computer Science 2025-11-13 Shuting Jin , Yi Jiang , Yimin Liu , Tengfei Ma , Dongsheng Cao , Leyi Wei , Xiangrong Liu , Xiangxiang Zeng

Medical images often contain multiple labels with imbalanced distributions and co-occurrence, leading to bias in multi-label medical image classification. Close collaboration between medical professionals and machine learning practitioners…

Human-Computer Interaction · Computer Science 2025-07-30 Shaohan Shi , Yuheng Shao , Haoran Jiang , Yunjie Yao , Zhijun Zhang , Xu Ding , Quan Li

Vision-Language Models (VLMs) trained via contrastive learning have achieved notable success in natural image tasks. However, their application in the medical domain remains limited due to the scarcity of openly accessible, large-scale…

Computer Vision and Pattern Recognition · Computer Science 2024-12-16 Muhammad Uzair Khattak , Shahina Kunhimon , Muzammal Naseer , Salman Khan , Fahad Shahbaz Khan

Medical decision-making requires integrating diverse medical information, from imaging to clinical narratives. These medical modalities are often acquired in a many-to-many manner. However, current medical vision-language pretraining models…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Jianzhong You , Chris McIntosh

Laboratory testing and medication prescription are two of the most important routines in daily clinical practice. Developing an artificial intelligence system that can automatically make lab test imputations and medication recommendations…

Machine Learning · Computer Science 2022-02-07 Chengsheng Mao , Liang Yao , Yuan Luo

Clinical trials often seek to determine the superiority, equivalence, or non-inferiority of an experimental condition (e.g., a new drug) compared to a control condition (e.g., a placebo or an already existing drug). The use of frequentist…

Other Statistics · Statistics 2022-05-09 Maximilian Linde , Don van Ravenzwaaij

Alzheimer's disease (AD) diagnosis requires integrating neuroimaging with heterogeneous clinical evidence and reasoning under established criteria, yet most multimodal models remain opaque and weakly guideline-aligned. We present…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Qiuhui Chen , Yushan Deng , Xuancheng Yao , Yi Hong

Clinical trials are the basis of Evidence-Based Medicine. Trial results are reviewed by experts and consensus panels for producing meta-analyses and clinical practice guidelines. However, reviewing these results is a long and tedious task,…

Computers and Society · Computer Science 2021-04-21 Jean-Baptiste Lamy

Since coronavirus has shown up, inaccessibility of legitimate clinical resources is at its peak, like the shortage of specialists, healthcare workers, lack of proper equipment and medicines. The entire medical fraternity is in distress,…

Information Retrieval · Computer Science 2021-04-06 Satvik Garg

Objective: This paper introduces a patient simulator for scalable, automated evaluation of healthcare conversational agents, generating realistic, controllable interactions that systematically vary across medical, linguistic, and behavioral…

Medical dialogue systems (MDSs) aim to assist doctors and patients with a range of professional medical services, i.e., diagnosis, treatment and consultation. The development of MDSs is hindered because of a lack of resources. In…

Computation and Language · Computer Science 2022-03-02 Guojun Yan , Jiahuan Pei , Pengjie Ren , Zhaochun Ren , Xin Xin , Huasheng Liang , Maarten de Rijke , Zhumin Chen

Empiric antibiotic prescribing in high-risk clinical contexts often requires decision making under conditions of incomplete information, where inappropriate coverage or unjustified escalation may compromise safety and antimicrobial…

Computers and Society · Computer Science 2026-03-12 Francisco José Gárate , Paloma Chausa , Diego Moreno , Judit López Luque , Vicens Díaz-Brito , Enrique Javier Gómez