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We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we…

Soft Condensed Matter · Physics 2015-08-07 Amin Doostmohammadi , Sumesh P. Thampi , Thuan B. Saw , Chwee T. Lim , Benoit Ladoux , Julia M. Yeomans

Cell membranes are studded with protrusions that were thoroughly analyzed with electron microscopy. However, the nanometer-scale three-dimensional motions generated by cell membranes to fit the topography of foreign surfaces and initiate…

Biological Physics · Physics 2008-09-04 Anne Pierres , Anne-Marie Benoliel , Dominique Touchard , Pierre Bongrand

Active nematics are microscopically driven liquid crystals that exhibit dynamical steady states characterized by the creation and annihilation of topological defects. Motivated by experimental realizations of such systems made of biopolymer…

Soft Condensed Matter · Physics 2018-09-05 Abhijeet Joshi , Elias Putzig , Aparna Baskaran , Michael Hagan

We present a hydrodynamic model for a thin spherical shell of active nematic liquid crystal with an arbitrary configuration of defects. The active flows generated by defects in the director lead to the formation of stable vortices,…

Soft Condensed Matter · Physics 2017-11-13 Diana Khoromskaia , Gareth P. Alexander

We numerically study the coarsening of topological defects in 2D polar active matter and make several interesting observations and predictions. (i) The long time state is characterized by nonzero density of defects, in stark contrast to…

Soft Condensed Matter · Physics 2025-09-30 Soumyadeep Mondal , Pankaj Popli , Sumantra Sarkar

We study a mixture of extensile and contractile cells using a vertex model extended to include active nematic stresses. The two cell populations phase separate over time. While phase separation strengthens monotonically with an increasing…

Soft Condensed Matter · Physics 2024-10-11 Jan Rozman , Julia M. Yeomans

Although cell monolayers typically remain confluent, they can spontaneously develop persistent holes as a result of collective cellular motion. Recent studies on MDCK monolayers cultured on soft substrates have revealed that cells can align…

Soft Condensed Matter · Physics 2025-08-11 Diogo E. P. Pinto , Jan Rozman , Julia M. Yeomans

We consider Lagrangians in 3+1 dimensions admitting topological defects where there is an additional coupling between the defect scalar field $\Phi$ and the gauge field kinetic term (eg $B(\vert \Phi \vert^2) F_{\mu \nu}F^{\mu \nu}$). Such…

High Energy Physics - Theory · Physics 2015-06-19 Nikos Platis , Ioannis Antoniou , Leandros Perivolaropoulos

The collective behaviour of confluent cell sheets is strongly influenced both by polar forces, arising through cytoskeletal propulsion and by active inter-cellular forces, which are mediated by interactions across cell-cell junctions. We…

Soft Condensed Matter · Physics 2020-05-28 Guanming Zhang , Romain Mueller , Amin Doostmohammadi , Julia M. Yeomans

Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this…

Flat sheets encoded with patterns of contraction/elongation morph into curved surfaces. If the surfaces bear Gauss curvature, the resulting actuation can be strong and powerful. We deploy the Gauss-Bonnet theorem to deduce the Gauss…

Soft Condensed Matter · Physics 2021-07-01 Daniel Duffy , John S. Biggins

We investigate the effects of extrinsic curvature on the turbulent behavior of a 2D active nematic confined to the surface of a cylinder. The surface of a cylinder has no intrinsic curvatrue and only extrinsic curvature. A nematic field…

Soft Condensed Matter · Physics 2020-08-26 D. J. G. Pearce

Active nematics are out-of-equilibrium systems in which energy injection at the microscale drives emergent collective behaviors, from spontaneous flows to active turbulence. While the dynamics of these systems have been extensively studied,…

Soft Condensed Matter · Physics 2025-04-15 Ahmet Umut Akduman , Yusuf Sariyar , Giuseppe Negro , Livio Nicola Carenza

Activity-driven modeling has been recently proposed as an alternative growth mechanism for time varying networks, displaying power-law degree distribution in time-aggregated representation. This approach assumes memoryless agents developing…

Physics and Society · Physics 2015-06-18 A. D. Medus , C. O. Dorso

The effects of an electric field on the flow patterns and defect dynamics of two-dimensional active nematics are numerically investigated. We found that field-induced director reorientation causes anisotropic active turbulence characterized…

Soft Condensed Matter · Physics 2023-07-20 Yutaka Kinoshita , Nariya Uchida

In random cellular systems, both observation and maximum entropy inference give a specific form to the topological pair correlation: it is bi-affine in the cells number of edges with coefficients depending on the distance between the two…

Soft Condensed Matter · Physics 2007-09-14 Faez Miri , Christophe Oguey

The importance of molecular-scale forces in sculpting biological form and function has been acknowledged for more than a century. Accounting for forces in biology is a problem that lies at the intersection of soft condensed matter physics,…

Soft Condensed Matter · Physics 2025-12-10 K. Vijay Kumar , Mandar M. Inamdar , Pramod A. Pullarkat , Gautam I. Menon

In this work, we report a direct measurement of the forces exerted by a tubulin/kinesin active nematic gel as well as its complete rheological characterization, including the quantification of its shear viscosity, {\eta}, and its activity…

Soft Condensed Matter · Physics 2024-04-22 Ignasi Vélez-Cerón , Pau Guillamat , Francesc Sagués , Jordi Ignés-Mullol

We propose a reaction-diffusion system that converts topological information of an active nematic into chemical signals. We show that a curvature-activated reaction dipole is sufficient for creating a system that dynamically senses topology…

Soft Condensed Matter · Physics 2025-01-09 Michael M. Norton , Piyush Grover

Using agent-based simulations of self-propelled particles subject to short-range repulsion and nematic alignment we explore the dynamical phases of a dense active material confined to the surface of a sphere. We map the dynamical phase…

Soft Condensed Matter · Physics 2018-04-25 Silke Henkes , M. Cristina Marchetti , Rastko Sknepnek