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Spectral computed tomography (CT) with photon-counting detectors holds immense potential for material discrimination and tissue characterization. However, under ultra-low-dose conditions, the sharply degraded signal-to-noise ratio (SNR) in…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Peng Peng , Xinrui Zhang , Junlin Wang , Lei Li , Shaoyu Wang , Qiegen Liu

X-ray Fluorescence Computed Tomography(XFCT) is a prevalent experimental technique which is utilized to investigate the spatial distribution of elements in sample. The sensitivity of L-shell XFCT of some elements is lower than that of…

Instrumentation and Detectors · Physics 2014-04-30 Liu Long , Huang Yang , Ma Bo , Xu Qing , Yan Lingtong , Li Li , Feng Songlin , Feng Xiangqian

The characteristics of an x-ray spectrum can greatly influence imaging and related tasks. In practice, due to the pile-up effect of the detector, it's difficult to directly measure the spectrum of a CT scanner using an energy resolved…

Medical Physics · Physics 2015-03-09 Wei Zhao , Kai Niu , Sebastian Schafer , Kevin Royalty

X-ray energy spectrum plays an essential role in imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of the spectrum estimation methods are indirect and are usually suffered from various limitations. The…

Medical Physics · Physics 2016-04-19 Wei Zhao , Qiude Zhang , Tianye Niu

IR microspectroscopy of single biological cells is challenged by strong light scattering, which produces baseline effects and peak distortions in the IR spectra and hinders the direct extraction of chemical information. Current methods for…

Cone-beam CT (CBCT) is widely used in clinical radiotherapy for image-guided treatment, improving setup accuracy, adaptive planning, and motion management. However, slow gantry rotation limits performance by introducing motion artifacts,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Yuan Gao , Shaoyan Pan , Mingzhe Hu , Huiqiao Xie , Jill Remick , Chih-Wei Chang , Justin Roper , Zhen Tian , Xiaofeng Yang

Quantitative estimation of contrast agent concentration is made possible by spectral CT and material decomposition. There are several approaches to modulate the sensitivity of the imaging system to obtain the different spectral channels…

Medical Physics · Physics 2020-10-16 Matthew Tivnan , Wenying Wang , Grace Gang , Eleni Liapi , Peter Noel , J. Webster Stayman

Online dose calculations before radiation treatment have applications in dose delivery verification, plan adaptation, and treatment planning. We propose a novel CBCT imaging pipeline to enhance accuracy. Our approach aims to improve HU…

The Brighter-Fatter (hereafter BF) effect in CCD sensors causes increases in the image size of bright objects due to electrostatic repulsion of collected charges. Correcting this effect in the LSST camera is required in order to meet the…

Instrumentation and Methods for Astrophysics · Physics 2019-11-22 Craig Lage

Cone-beam computed tomography (CBCT) images are problematic in clinical medicine because of their low contrast and high artifact content compared with conventional CT images. Although there are some studies to improve image quality, in…

Image and Video Processing · Electrical Eng. & Systems 2026-03-30 Naruki Murahashi , Mitsuhiro Nakamura , Megumi Nakao

Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and…

Medical Physics · Physics 2018-03-19 Wei Zhao , Don Vernekohl , Fei Han , Bin Han , Hao Peng , Lei Xing , James K Min

In this paper we present a method of scintillation detector energy calibration using the gamma-rays. The technique is based on the Compton scattering of gamma-rays in a scintillation detector and subsequent photoelectric absorption of the…

Instrumentation and Detectors · Physics 2016-04-20 S. V. Bakhlanov , N. V. Bazlov , A. V. Derbin , I. S. Drachnev , A. S. Kayunov , V. N. Muratova , D. A. Semenov , E. V. Unzhakov

Photon counting CT (PCCT) has been a research focus in the last two decades. Recent studies and advancements have demonstrated that systems using semiconductor-based photon counting detectors (PCDs) have the potential to provide better…

Accurate quantification in positron emission tomography (PET) is essential for accurate diagnostic results and effective treatment tracking. A major issue encountered in PET imaging is attenuation. Attenuation refers to the diminution of…

In this paper, an improved scatter correction with moving beam stop array (BSA) for x-ray cone beam (CB) CT is proposed. Firstly, correlation between neighboring CB views is deduced based on John's Equation. Then, correlation-based…

Medical Physics · Physics 2014-10-31 Hao Yan , Xuanqin Mou , Shaojie Tang , Qiong Xu

The fastCAT application uses pre-calculated Monte Carlo (MC) CBCT phantom-specific scatter and detector response functions to reduce simulation time for megavoltage (MV) and kilovoltage (kV) CBCT imaging. Pre-calculated x-ray beam energy…

Medical Physics · Physics 2021-09-15 Jericho O'Connell , Magdalena Bazalova-Carter

According to the theory of quantum electrodynamics, photon-photon scattering can take place via exchange of virtual electron-positron pairs. Effectively, the interaction can be formulated in terms of non-linear corrections to Maxwell's…

High Energy Physics - Phenomenology · Physics 2007-05-23 E. Lundstrom

Cone-beam CT (CBCT) has been widely used in image guided radiation therapy (IGRT) to acquire updated volumetric anatomical information before treatment fractions for accurate patient alignment purpose. However, the excessive x-ray imaging…

Medical Physics · Physics 2010-04-13 Xun Jia , Yifei Lou , John Lewis , Ruijiang Li , Xuejun Gu , Chunhua Men , William Y. Song , Steve B. Jiang

X-ray dark-field or ultra-small angle scatter imaging has become increasingly important since the introduction of phase-based x-ray imaging and is having transformative impact in fields such as in vivo lung imaging and explosives detection.…

A point-spread function describes the optics of an imaging system and can be used to correct collected images for instrumental effects. The state of the art for deconvolving images with the point-spread function is the Richardson-Lucy…

Instrumentation and Methods for Astrophysics · Physics 2024-05-07 Stefan Johann Hofmeister
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