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Deep learning has shown great potential for automated medical image segmentation to improve the precision and speed of disease diagnostics. However, the task presents significant difficulties due to variations in the scale, shape, texture,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-06 Shahzaib Iqbal , Tariq M. Khan , Syed S. Naqvi , Asim Naveed , Erik Meijering

Accurate and efficient cell nuclei detection and classification in histopathological Whole Slide Images (WSIs) are pivotal for digital pathology applications. Traditional cell segmentation approaches, while commonly used, are…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Oscar Pina , Eduard Dorca , Verónica Vilaplana

Cell segmentation for multi-modal microscopy images remains a challenge due to the complex textures, patterns, and cell shapes in these images. To tackle the problem, we first develop an automatic cell classification pipeline to label the…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Wei Lou , Xinyi Yu , Chenyu Liu , Xiang Wan , Guanbin Li , Siqi Liu , Haofeng Li

In this article, we look into some essential aspects of convolutional neural networks (CNNs) with the focus on medical image segmentation. First, we discuss the CNN architecture, thereby highlighting the spatial origin of the data,…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 Jeroen Bertels , David Robben , Robin Lemmens , Dirk Vandermeulen

Nuclei segmentation and classification is the first and most crucial step that is utilized for many different microscopy medical analysis applications. However, it suffers from many issues such as the segmentation of small objects,…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Hussam Azzuni , Muhammad Ridzuan , Min Xu , Mohammad Yaqub

The effective receptive field (ERF) plays an important role in transform coding, which determines how much redundancy can be removed during transform and how many spatial priors can be utilized to synthesize textures during inverse…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Wei Jiang , Peirong Ning , Jiayu Yang , Yongqi Zhai , Feng Gao , Ronggang Wang

In this paper, we propose a new model to segment cells in phase contrast microscopy images. Cell images collected from the similar scenario share a similar background. Inspired by this, we separate cells from the background in images by…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Lin Zhang

Accurate nuclei segmentation is an essential foundation for various applications in computational pathology, including cancer diagnosis and treatment planning. Even slight variations in nuclei representations can significantly impact these…

Image and Video Processing · Electrical Eng. & Systems 2024-07-30 Zunaira Rauf , Abdul Rehman Khan , Asifullah Khan

Automatic segmentation of microscopy images is an important task in medical image processing and analysis. Nucleus detection is an important example of this task. Mask-RCNN is a recently proposed state-of-the-art algorithm for object…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Jeremiah W. Johnson

Automation-assisted cervical screening via Pap smear or liquid-based cytology (LBC) is a highly effective cell imaging based cancer detection tool, where cells are partitioned into "abnormal" and "normal" categories. However, the success of…

Computer Vision and Pattern Recognition · Computer Science 2018-01-29 Ling Zhang , Le Lu , Isabella Nogues , Ronald M. Summers , Shaoxiong Liu , Jianhua Yao

Instance segmentation and classification of nuclei is an important task in computational pathology. We show that StarDist, a deep learning nuclei segmentation method originally developed for fluorescence microscopy, can be extended and…

Computer Vision and Pattern Recognition · Computer Science 2022-08-22 Martin Weigert , Uwe Schmidt

Medical image segmentation plays a pivotal role in disease diagnosis and treatment planning, particularly in resource-constrained clinical settings where lightweight and generalizable models are urgently needed. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Chengqi Dong , Fenghe Tang , Rongge Mao , Xinpei Gao , S. Kevin Zhou

Cell instance segmentation is critical to analyzing biomedical images, yet accurately distinguishing tightly touching cells remains a persistent challenge. Existing instance segmentation frameworks, including detection-based, contour-based,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Ye Zhang , Yu Zhou , Yifeng Wang , Jun Xiao , Ziyue Wang , Yongbing Zhang , Jianxu Chen

Brain tumor classification using MRI images is critical in medical diagnostics, where early and accurate detection significantly impacts patient outcomes. While recent advancements in deep learning (DL), particularly CNNs, have shown…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Priyam Ganguly , Akhilbaran Ghosh

Histopathology image analysis plays a critical role in cancer diagnosis and treatment. To automatically segment the cancerous regions, fully supervised segmentation algorithms require labor-intensive and time-consuming labeling at the pixel…

Image and Video Processing · Electrical Eng. & Systems 2019-08-29 Gang Xu , Zhigang Song , Zhuo Sun , Calvin Ku , Zhe Yang , Cancheng Liu , Shuhao Wang , Jianpeng Ma , Wei Xu

Automatic cell detection in histology images is a challenging task due to varying size, shape and features of cells and stain variations across a large cohort. Conventional deep learning methods regress the probability of each pixel…

Computer Vision and Pattern Recognition · Computer Science 2018-06-20 Shan E Ahmed Raza , Khalid AbdulJabbar , Mariam Jamal-Hanjani , Selvaraju Veeriah , John Le Quesne , Charles Swanton , Yinyin Yuan

Nuclei segmentation is a fundamental task that is critical for various computational pathology applications including nuclei morphology analysis, cell type classification, and cancer grading. Conventional vision-based methods for nuclei…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Faisal Mahmood , Daniel Borders , Richard Chen , Gregory N. McKay , Kevan J. Salimian , Alexander Baras , Nicholas J. Durr

Accurate segmentation of skin lesions within dermoscopic images plays a crucial role in the timely identification of skin cancer for computer-aided diagnosis on mobile platforms. However, varying shapes of the lesions, lack of defined…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Hamza Farooq , Zuhair Zafar , Ahsan Saadat , Tariq M Khan , Shahzaib Iqbal , Imran Razzak

There is large consent that successful training of deep networks requires many thousand annotated training samples. In this paper, we present a network and training strategy that relies on the strong use of data augmentation to use the…

Computer Vision and Pattern Recognition · Computer Science 2015-05-19 Olaf Ronneberger , Philipp Fischer , Thomas Brox

This paper proposes the paradigm of large convolutional kernels in designing modern Convolutional Neural Networks (ConvNets). We establish that employing a few large kernels, instead of stacking multiple smaller ones, can be a superior…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Yiyuan Zhang , Xiaohan Ding , Xiangyu Yue