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Histochemical staining is essential for visualizing tissue architecture and cellular morphology but is destructive and limited by the availability of tissue for multiple stains. Virtual staining with label-free microscopy offers a…
Virtual histology is an emerging field in biomedicine that enables three-dimensional tissue visualization using X-ray micro-computed tomography. However, the method still lacks the specificity of conventional histology, in which parts of…
Evaluation of AI systems often requires synthetic test cases, particularly for rare or safety-critical conditions that are difficult to observe in operational data. Generative AI offers a promising approach for producing such data through…
Design inspiration is crucial for establishing the direction of a design as well as evoking feelings and conveying meanings during the conceptual design process. Many practice designers use text-based searches on platforms like Pinterest to…
Spatial transcriptomics (ST) bridges gene expression and tissue morphology but faces clinical adoption barriers due to technical complexity and prohibitive costs. While computational methods predict gene expression from H&E-stained…
Hematoxylin and Eosin (H&E) stained Whole Slide Images (WSIs) are utilized for biopsy visualization-based diagnostic and prognostic assessment of diseases. Variation in the H&E staining process across different lab sites can lead to…
In digital pathology, many image analysis tasks are challenged by the need for large and time-consuming manual data annotations to cope with various sources of variability in the image domain. Unsupervised domain adaptation based on…
Generative virtual staining (VS) models for high-throughput screening (HTS) can provide an estimated posterior distribution of possible biological feature values for each input and cell. However, when evaluating a VS model, the true…
"Is it possible to predict expression levels of different genes at a given spatial location in the routine histology image of a tumor section by modeling its stain absorption characteristics?" In this work, we propose a "stain-aware"…
Pathological glomerulus classification plays a key role in the diagnosis of nephropathy. As the difference between different subcategories is subtle, doctors often refer to slides from different staining methods to make decisions. However,…
Domain shift is a problem commonly encountered when developing automated histopathology pipelines. The performance of machine learning models such as convolutional neural networks within automated histopathology pipelines is often…
In pathological research, education, and clinical practice, the decision-making process based on pathological images is critically important. This significance extends to digital pathology image analysis: its adequacy is demonstrated by the…
Incorporating artificial intelligence (AI) into digital pathology offers promising prospects for automating and enhancing tasks such as image analysis and diagnostic processes. However, the diversity of tissue samples and the necessity for…
Generative learning models in medical research are crucial in developing training data for deep learning models and advancing diagnostic tools, but the problem of high-quality, diverse images is an open topic of research. Quantum-enhanced…
We fine-tuned a foundational stable diffusion model using X-ray scattering images and their corresponding descriptions to generate new scientific images from given prompts. However, some of the generated images exhibit significant…
Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present…
Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, assay cost, and workflow constraints.…
Advances in Generative AI tools have allowed designers to manipulate existing 3D models using text or image-based prompts, enabling creators to explore different design goals. Photochromic color-changing systems, on the other hand, allow…
The design of personalized cranial implants is a challenging and tremendous task that has become a hot topic in terms of process automation with the use of deep learning techniques. The main challenge is associated with the high diversity…
Generative Artificial Intelligence (GenAI) is taking the world by storm. It promises transformative opportunities for advancing and disrupting existing practices, including healthcare. From large language models (LLMs) for clinical note…